دورية أكاديمية
أعرض في EDS

An initial comparative genomic autopsy of wasting disease in sea stars.

التفاصيل البيبلوغرافية
العنوان: An initial comparative genomic autopsy of wasting disease in sea stars.
المؤلفون: Ruiz-Ramos DV; Department of Life and Environmental Sciences, University of California, Merced, CA, USA., Schiebelhut LM; Department of Life and Environmental Sciences, University of California, Merced, CA, USA., Hoff KJ; Institute for Computer Science and Mathematics, University of Greifswald, Greifswald, Germany.; Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany., Wares JP; Department of Genetics and the Odum School of Ecology, University of Georgia, Athens, GA, USA., Dawson MN; Department of Life and Environmental Sciences, University of California, Merced, CA, USA.
المصدر: Molecular ecology [Mol Ecol] 2020 Mar; Vol. 29 (6), pp. 1087-1102. Date of Electronic Publication: 2020 Mar 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9214478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-294X (Electronic) Linking ISSN: 09621083 NLM ISO Abbreviation: Mol Ecol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, UK : Blackwell Scientific Publications, c1992-
مواضيع طبية MeSH: Starfish/*genetics , Wasting Syndrome/*veterinary, Animals ; California ; Forensic Sciences ; Genome ; Genome, Mitochondrial ; Genomics ; Pacific Ocean ; Transcriptome
مستخلص: Beginning in 2013, sea stars throughout the Eastern North Pacific were decimated by wasting disease, also known as "asteroid idiopathic wasting syndrome" (AIWS) due to its elusive aetiology. The geographic extent and taxonomic scale of AIWS meant events leading up to the outbreak were heterogeneous, multifaceted, and oftentimes unobserved; progression from morbidity to death was rapid, leaving few tell-tale symptoms. Here, we take a forensic genomic approach to discover candidate genes that may help explain sea star wasting syndrome. We report the first genome and annotation for Pisaster ochraceus, along with differential gene expression (DGE) analyses in four size classes, three tissue types, and in symptomatic and asymptomatic individuals. We integrate nucleotide polymorphisms associated with survivors of the wasting disease outbreak, DGE associated with temperature treatments in P. ochraceus, and DGE associated with wasting in another asteroid Pycnopodia helianthoides. In P. ochraceus, we found DGE across all tissues, among size classes, and between asymptomatic and symptomatic individuals; the strongest wasting-associated DGE signal was in pyloric caecum. We also found previously identified outlier loci co-occur with differentially expressed genes. In cross-species comparisons of symptomatic and asymptomatic individuals, consistent responses distinguish genes associated with invertebrate innate immunity and chemical defence, consistent with context-dependent stress responses, defensive apoptosis, and tissue degradation. Our analyses thus highlight genomic constituents that may link suspected environmental drivers (elevated temperature) with intrinsic differences among individuals (age/size, alleles associated with susceptibility) that elicit organismal responses (e.g., coelomocyte proliferation) and manifest as sea star wasting mass mortality.
(© 2020 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: asteroid idiopathic wasting syndrome (AIWS); disease; gene expression; genome; mass mortality; sea star wasting disease (SSWD)
تواريخ الأحداث: Date Created: 20200219 Date Completed: 20210301 Latest Revision: 20210301
رمز التحديث: 20240628
DOI: 10.1111/mec.15386
PMID: 32069379
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-294X
DOI:10.1111/mec.15386