دورية أكاديمية
[Elevated liver enzyme levels; not exclusive to liver disease].
| العنوان: | [Elevated liver enzyme levels; not exclusive to liver disease]. |
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| عنوان ترانسليتريتد: | Leverenzymstoornissen: niet alleen bij leverziekten. |
| المؤلفون: | Groen MT; Radboudumc, Afd. Maag-, Darm- en Leverziekten, Nijmegen.; Contact: M. te Groen (maarten.tegroen@radboudumc.nl)., Drenth JPH; Radboudumc, Afd. Maag-, Darm- en Leverziekten, Nijmegen., Voermans N; Radboudumc, Afd. Neurologie, Nijmegen. |
| المصدر: | Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2019 Nov 28; Vol. 163. Date of Electronic Publication: 2019 Nov 28. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | Dutch; Flemish |
| بيانات الدورية: | Publisher: Vereniging NTvG Country of Publication: Netherlands NLM ID: 0400770 Publication Model: Electronic Cited Medium: Internet ISSN: 1876-8784 (Electronic) Linking ISSN: 00282162 NLM ISO Abbreviation: Ned Tijdschr Geneeskd Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017?-: Amsterdam : Vereniging NTvG Original Publication: Houten : Bohn Stafleu van Loghum |
| مواضيع طبية MeSH: | Anoctamins/*genetics , Liver Diseases/*diagnosis , Liver Function Tests/*methods , Muscular Diseases/*diagnosis, Adult ; Creatine Kinase/blood ; Diagnosis, Differential ; Female ; Humans ; Muscular Diseases/blood ; Muscular Diseases/genetics ; Muscular Diseases/physiopathology ; Mutation ; Transaminases/blood |
| مستخلص: | Background: Underlying liver disease is usually, quite rightly, suspected in patients with raised liver enzyme levels. Thesecan, however, actually have a different cause, such as a muscular disease. Case Description: A 41-year-old woman was referred to a gastroenterology clinic with unexplained elevated liver enzymelevels and fatigue. She had experienced mildly raised liver enzyme levels 10 years previously; following analysis these were interpreted as due to 'non-alcoholic fatty liver disease'. Further questioning revealed that the patient had also recently been experiencing muscular pain and had difficulty with rising from a sitting position. Laboratory investigation revealed elevated aminotransferase and creatinine kinase (CK) levels. The symptoms and the abnormal laboratory results were found to be due to a mutation of the ANO5 gene. Conclusion: A mild liver enzyme disorder can indicate a muscular disease. It is sensible to measure CK levels early, in order to distinguish between a muscular disease and other causes of the raised liver enzyme level. This may prevent unnecessary, invasive and expensive diagnostics. |
| المشرفين على المادة: | 0 (ANO5 protein, human) 0 (Anoctamins) EC 2.6.1.- (Transaminases) EC 2.7.3.2 (Creatine Kinase) |
| تواريخ الأحداث: | Date Created: 20200220 Date Completed: 20200529 Latest Revision: 20200529 |
| رمز التحديث: | 20221213 |
| PMID: | 32073783 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1876-8784 |
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