دورية أكاديمية
أعرض في EDS

Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study.

التفاصيل البيبلوغرافية
العنوان: Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study.
المؤلفون: Stamboni MB; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, São Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo 05403-010, SP, Brazil., Gomes ÁNM; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, São Paulo 01508-010, Brazil., Souza MM; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, São Paulo 01508-010, Brazil., Oliveira KK; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, São Paulo 01508-010, Brazil., Arruda CFJ; Department of General Pathology, Dental School, University of São Paulo, São Paulo 05508-000, Brazil., de Paula F; Department of General Pathology, Dental School, University of São Paulo, São Paulo 05508-000, Brazil., Bettim BB; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, São Paulo 01508-010, Brazil., Marques MM; Department of Restorative Dentistry, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil., Kowalski LP; Department of Head and Neck Surgery and Otorhinolaryngology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Pinto CAL; Department of Anatomic Pathology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil., Arana-Chavez VE; Laboratory of Oral Biology, Department of Biomaterials and Oral Biology, Dental School, University of São Paulo, São Paulo 05508-000, Brazil., Lourenço SV; Department of General Pathology, Dental School, University of São Paulo, São Paulo 05508-000, Brazil., Coutinho-Camillo CM; International Research Center, A.C.Camargo Cancer Center, Rua Taguá 440, São Paulo 01508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, São Paulo 05403-010, SP, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2020 Feb 14; Vol. 21 (4). Date of Electronic Publication: 2020 Feb 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Aquaporin 1/*metabolism , Aquaporin 3/*metabolism , Aquaporin 5/*metabolism , Carcinoma, Mucoepidermoid/*pathology , Salivary Gland Neoplasms/*pathology, Adult ; Carcinoma, Mucoepidermoid/metabolism ; Carcinoma, Mucoepidermoid/mortality ; Cell Line, Tumor ; Epithelial Cells/pathology ; Epithelial Cells/ultrastructure ; Female ; Humans ; Immunohistochemistry ; Male ; Microscopy, Electron ; Middle Aged ; Phenotype ; Pilot Projects ; Salivary Gland Neoplasms/metabolism ; Salivary Gland Neoplasms/mortality ; Survival Rate
مستخلص: Salivary gland aquaporins (AQPs) are essential for the control of saliva production and maintenance of glandular structure. However, little is known of their role in salivary gland neoplasia. Salivary gland tumors comprise a heterogeneous group of lesions, featuring variable histological characteristics and diverse clinical behaviors. Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. The aim of this study was to evaluate the expression of AQP1, AQP3, and AQP5 in 24 MEC samples by immunohistochemistry. AQP1 expression was observed in vascular endothelium throughout the tumor stroma. AQP3 was expressed in epidermoid and mucosal cells and AQP5 was expressed in mucosal cells of MEC. These proteins were expressed in the human MEC cell line UH-HMC-3A. Cellular ultrastructural aspects were analyzed by electron microscopy to certificate the tumor cell phenotype. In summary, our results show that, despite the fact that these molecules are important for salivary gland physiology, they may not play a distinct role in tumorigenesis in MEC. Additionally, the in vitro model may offer new possibilities to further investigate mechanisms of these molecules in tumor biology and their real significance in prognosis and possible target therapies.
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معلومات مُعتمدة: 11/02051-6 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة: Keywords: aquaporins; electron microscopy; immunofluorescence; immunohistochemistry; mucoepidermoid carcinoma
المشرفين على المادة: 0 (Aquaporin 5)
146410-94-8 (Aquaporin 1)
158801-98-0 (Aquaporin 3)
تواريخ الأحداث: Date Created: 20200221 Date Completed: 20201120 Latest Revision: 20201120
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7073006
DOI: 10.3390/ijms21041287
PMID: 32075009
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms21041287