دورية أكاديمية
Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice.
| العنوان: | Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice. |
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| المؤلفون: | Demarque KC; Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Dutra-Tavares AC; Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Nunes-Freitas AL; Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Araújo UC; Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Manhães AC; Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Abreu-Villaça Y; Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Filgueiras CC; Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Ribeiro-Carvalho A; Departamento de Ciências, Faculdade de Formação de Professores da Universidade do Estado do Rio de Janeiro, São Gonçalo, Brazil. |
| المصدر: | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2020 May; Vol. 80 (3), pp. 197-207. Date of Electronic Publication: 2020 Mar 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 8401784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-474X (Electronic) Linking ISSN: 07365748 NLM ISO Abbreviation: Int J Dev Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Inc. Original Publication: Oxford : New York : Pergamon Press, c1983- |
| مواضيع طبية MeSH: | Social Behavior*, Behavior, Animal/*drug effects , Cerebral Cortex/*drug effects , Ethanol/*pharmacology, Animals ; Cerebral Cortex/metabolism ; Corticosterone/blood ; Hydroxyindoleacetic Acid/metabolism ; Male ; Mice ; Motor Activity/drug effects ; Receptor, Serotonin, 5-HT2A/metabolism |
| مستخلص: | The brain is particularly vulnerable to ethanol effects during its growth spurt. Outcomes of early ethanol exposure such as hyperactivity have been extensively investigated; however, persons with fetal alcohol spectrum disorder frequently have social impairments and are heavy drinkers. Despite that, scant information is available regarding the neurobiological basis of these latter behavioral issues. Here, Swiss mice exposed to ethanol (Etoh, 5 g/kg i.p., alternate days) or saline during the brain growth spurt [postnatal day (PN) 2 to 8] were used to assess social behavior after an ethanol challenging during adolescence. At PN39, animals were administered with a single ethanol dose (1 g/Kg) or water by gavage and were then evaluated in the three-chamber sociability test. We also evaluated corticosterone serum levels and the frontal cerebral cortex serotoninergic system. Etoh males showed reductions in sociability. Ethanol challenging reverted these alterations in social behavior, reduced corticosterone levels, and increased the 5-HT (© 2020 International Society for Developmental Neuroscience.) |
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| معلومات مُعتمدة: | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) |
| فهرسة مساهمة: | Keywords: corticosterone; development; serotoninergic system; social behavior |
| المشرفين على المادة: | 0 (Receptor, Serotonin, 5-HT2A) 3K9958V90M (Ethanol) 54-16-0 (Hydroxyindoleacetic Acid) W980KJ009P (Corticosterone) |
| تواريخ الأحداث: | Date Created: 20200221 Date Completed: 20210303 Latest Revision: 20210303 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/jdn.10017 |
| PMID: | 32077124 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-474X |
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| DOI: | 10.1002/jdn.10017 |