دورية أكاديمية

Management of Mantle Cell Lymphoma in the Era of Novel Oral Agents.

التفاصيل البيبلوغرافية
العنوان: Management of Mantle Cell Lymphoma in the Era of Novel Oral Agents.
المؤلفون: Buege MJ; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kumar A; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dixon BN; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tang LA; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pak T; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Orozco J; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Peterson TJ; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Maples KT; Memorial Sloan Kettering Cancer Center, New York, NY, USA.
المصدر: The Annals of pharmacotherapy [Ann Pharmacother] 2020 Sep; Vol. 54 (9), pp. 879-898. Date of Electronic Publication: 2020 Feb 20.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Sage Country of Publication: United States NLM ID: 9203131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-6270 (Electronic) Linking ISSN: 10600280 NLM ISO Abbreviation: Ann Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Sept. 2013- : Thousand Oaks, CA : Sage
Original Publication: Cincinnati, OH : Harvey Whitney Books Co., c1992-
مواضيع طبية MeSH: Hematopoietic Stem Cell Transplantation*, Antineoplastic Combined Chemotherapy Protocols/*administration & dosage , Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Lymphoma, Mantle-Cell/*drug therapy, Administration, Oral ; Adult ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Humans ; Lymphoma, Mantle-Cell/pathology ; Male ; Middle Aged ; Treatment Outcome
مستخلص: Objectives: To discuss (1) recent and emerging data for pharmacological management of untreated and relapsed/refractory (R/R) mantle cell lymphoma (MCL) with agents approved in the United States, (2) important considerations for toxicity monitoring and management, and (3) preliminary data and ongoing studies for agents in MCL-specific clinical trials. Data Sources: PubMed/MEDLINE, EMBASE, Google Scholar, product labeling, National Comprehensive Cancer Network, American Cancer Society, and ClinicalTrials.gov were searched for studies published between January 1, 2017, and January 31, 2020, and key historical trials. Study Selection and Data Extraction: Relevant studies conducted in humans and selected supporting preclinical data were reviewed. Data Synthesis: MCL is a rare but usually aggressive non-Hodgkin lymphoma that most commonly affects the older population. Traditionally, the treatment of MCL has been determined based on transplant eligibility. Newer data suggest that more tolerable frontline therapy may produce outcomes similar to intensive historical induction regimens, possibly precluding fewer patients from autologous stem cell transplant and producing better long-term outcomes in transplant-ineligible patients. In the R/R setting, novel regimens are improving outcomes and changing the landscape of treatment. Relevance to Patient Care and Clinical Practice: This review summarizes and discusses recent and emerging data for management of newly diagnosed and R/R MCL; key supportive care considerations for agents are also discussed. Conclusions: Recent study results are changing management of MCL. Although these data have complicated the picture of regimen selection, increasingly effective and tolerable therapy and additional anticipated data point to a brighter future for patients with MCL.
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معلومات مُعتمدة: P30 CA008748 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: bone marrow transplantation; clinical pharmacy; hematology; lymphoma; oncology
تواريخ الأحداث: Date Created: 20200222 Date Completed: 20201113 Latest Revision: 20240407
رمز التحديث: 20240407
مُعرف محوري في PubMed: PMC8330616
DOI: 10.1177/1060028020909117
PMID: 32079411
قاعدة البيانات: MEDLINE
الوصف
تدمد:1542-6270
DOI:10.1177/1060028020909117