دورية أكاديمية
أعرض في EDS

Multiple Levels of PGC-1α Dysregulation in Heart Failure.

التفاصيل البيبلوغرافية
العنوان: Multiple Levels of PGC-1α Dysregulation in Heart Failure.
المؤلفون: Oka SI; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark, NJ, United States., Sabry AD; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States., Cawley KM; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States., Warren JS; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States.; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States.; Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan.
المصدر: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2020 Jan 30; Vol. 7, pp. 2. Date of Electronic Publication: 2020 Jan 30 (Print Publication: 2020).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653388 Publication Model: eCollection Cited Medium: Print ISSN: 2297-055X (Print) Linking ISSN: 2297055X NLM ISO Abbreviation: Front Cardiovasc Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Metabolic adaption is crucial for the heart to sustain its contractile activity under various physiological and pathological conditions. At the molecular level, the changes in energy demand impinge on the expression of genes encoding for metabolic enzymes. Among the major components of an intricate transcriptional circuitry, peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) plays a critical role as a metabolic sensor, which is responsible for the fine-tuning of transcriptional responses to a plethora of stimuli. Cumulative evidence suggests that energetic impairment in heart failure is largely attributed to the dysregulation of PGC-1α. In this review, we summarize recent studies revealing how PGC-1α is regulated by a multitude of mechanisms, operating at different regulatory levels, which include epigenetic regulation, the expression of variants, post-transcriptional inhibition, and post-translational modifications. We further discuss how the PGC-1α regulatory cascade can be impaired in the failing heart.
(Copyright © 2020 Oka, Sabry, Cawley and Warren.)
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فهرسة مساهمة: Keywords: PGC-1α; cardiac metabolism; epigenetics; heart failure; histone methylation; mitochondria; transcriptional control
تواريخ الأحداث: Date Created: 20200222 Latest Revision: 20200928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7002390
DOI: 10.3389/fcvm.2020.00002
PMID: 32083094
قاعدة البيانات: MEDLINE
الوصف
تدمد:2297-055X
DOI:10.3389/fcvm.2020.00002