دورية أكاديمية
أعرض في EDS

Sepsis in cancer patients residing in Zimbabwe: spectrum of bacterial and fungal aetiologies and their antimicrobial susceptibility patterns.

التفاصيل البيبلوغرافية
العنوان: Sepsis in cancer patients residing in Zimbabwe: spectrum of bacterial and fungal aetiologies and their antimicrobial susceptibility patterns.
المؤلفون: Chinowaita F; Department of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe. fchinowaita@gmail.com.; Premier Services Medical Investments, Department of Microbiology, Harare, Zimbabwe. fchinowaita@gmail.com.; Department of Pathology (Microbiology), Midlands State University, Gweru, Zimbabwe. fchinowaita@gmail.com., Chaka W; Department of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Nyazika TK; Malawi-Liverpool-Welcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.; Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands., Maboreke TC; Department of Haematology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Tizauone E; Department of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.; Premier Services Medical Investments, Department of Microbiology, Harare, Zimbabwe., Mapondera P; African Society Laboratory Medicine, Addis Ababa, Ethiopia., Chitsike I; Department of Paediatrics and Child Health, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Cakana AZ; Department of Haematology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Mavenyengwa RT; Department of Medical Microbiology, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
المصدر: BMC infectious diseases [BMC Infect Dis] 2020 Feb 21; Vol. 20 (1), pp. 161. Date of Electronic Publication: 2020 Feb 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Bacteria/*drug effects , Fungi/*drug effects , Neoplasms/*microbiology , Sepsis/*microbiology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bacteria/isolation & purification ; Child ; Child, Preschool ; Cross-Sectional Studies ; Drug Resistance, Microbial ; Female ; Fungi/isolation & purification ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Neoplasms/epidemiology ; Sepsis/epidemiology ; Young Adult ; Zimbabwe/epidemiology
مستخلص: Background: Cancer and sepsis comorbidity is a major public health problem in most parts of the world including Zimbabwe. The microbial aetiologies of sepsis and their antibiograms vary with time and locations. Knowledge on local microbial aetiologies of sepsis and their susceptibility patterns is critical in guiding empirical antimicrobial treatment choices.
Methods: This was a descriptive cross-sectional study which determined the microbial aetiologies of sepsis from blood cultures of paediatric and adult cancer patients obtained between July 2016 and June 2017. The TDR-X120 blood culture system and TDR 300B auto identification machine were used for incubation of blood culture bottles and identification plus antimicrobial susceptibility testing, respectively.
Results: A total of 142 participants were enrolled; 50 (35.2%) had positive blood cultures, with 56.0% Gram positive, 42.0% Gram-negative bacteria and 2.0% yeast isolated. Common species isolated included coagulase negative Staphylococcus spp. (CoNS) (22.0%), E. coli (16.0%), K. pneumoniae (14.0%), E. faecalis (14.0%) and S. aureus (8.0%). Gram-negative isolates exhibited high resistance to gentamicin (61.9%) and ceftriaxone (71.4%) which are the empiric antimicrobial agents used in our setting. Amikacin and meropenem showed 85.7 and 95.2% activity respectively against all Gram-negative isolates, whilst vancomycin and linezolid were effective against 96.2 and 100.0% of all Gram-positive isolates respectively. We isolated 10 (66.7%) extended spectrum β-lactamase (ESBL) amongst the E. coli and K. pneumoniae isolates. Ten (66.7%) of the Staphylococcus spp. were methicillin resistant.
Conclusions: CoNS, E. coli, K. pneumoniae, E. faecalis and S. aureus were the major microbial drivers of sepsis amongst cancer patients in Zimbabwe. Most isolates were found to be resistant to commonly used empirical antibiotics, with isolates exhibiting high levels of ESBL and methicillin resistance carriage. A nationwide survey on microbial aetiologies of sepsis and their susceptibility patterns would assist in the guidance of effective sepsis empiric antimicrobial treatment among patients with cancer.
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فهرسة مساهمة: Keywords: Aetiology; Antimicrobial resistance; Cancer; ESBL; Sepsis
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20200223 Date Completed: 20200413 Latest Revision: 20200413
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7035672
DOI: 10.1186/s12879-020-4886-2
PMID: 32085740
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2334
DOI:10.1186/s12879-020-4886-2