دورية أكاديمية
أعرض في EDS

Cellular, Molecular, and Immunological Characteristics of Langhans Multinucleated Giant Cells Programmed by IL-15.

التفاصيل البيبلوغرافية
العنوان: Cellular, Molecular, and Immunological Characteristics of Langhans Multinucleated Giant Cells Programmed by IL-15.
المؤلفون: Wang H; Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Jiang H; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Teles RMB; Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA., Chen Y; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Wu A; Suzhou Institute of Systems Medicine Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China., Lu J; Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA., Chen Z; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China., Ma F; Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA., Pellegrini M; Department of Molecular, Cell and Developmental Biology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA., Modlin RL; Department of Medicine, Division of Dermatology, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California (UCLA), Los Angeles, California, USA. Electronic address: rmodlin@mednet.ucla.edu.
المصدر: The Journal of investigative dermatology [J Invest Dermatol] 2020 Sep; Vol. 140 (9), pp. 1824-1836.e7. Date of Electronic Publication: 2020 Feb 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : New York : Elsevier
Original Publication: Baltimore, Williams & Wilkins.
مواضيع طبية MeSH: Macrophage Activation*, Giant Cells, Langhans/*immunology , Interleukin-15/*metabolism, Cell Communication/immunology ; Cells, Cultured ; Gene Regulatory Networks/immunology ; Giant Cells, Langhans/metabolism ; Humans ; Interferon-gamma/metabolism ; Primary Cell Culture ; RNA-Seq ; Signal Transduction/genetics ; Signal Transduction/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Transcriptome/immunology
مستخلص: Langhans multinucleated giant cells (LGCs) are a specific type of multinucleated giant cell containing a characteristic horseshoe-shaped ring of nuclei that are present within granulomas of infectious etiology. Although cytokines that trigger macrophage activation (such as IFN-γ) induce LGC formation, it is not clear whether cytokines that trigger macrophage differentiation contribute to LGC formation. Here, we found that IL-15, a cytokine that induces M1 macrophage differentiation, programs human peripheral blood adherent cells to form LGCs. Analysis of the IL-15‒treated adherent cell transcriptome identified gene networks for T cells, DNA damage and replication, and IFN-inducible genes that correlated with IL-15 treatment and LGC-type multinucleated giant cell formation. Gene networks enriched for myeloid cells were anticorrelated with IL-15 treatment and LGC formation. Functional studies revealed that T cells were required for IL-15‒induced LGC formation, involving a direct contact with myeloid cells through CD40L-CD40 interaction and IFN-γ release. These data indicate that IL-15 induces LGC formation through the direct interaction of activated T cells and myeloid cells.
(Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 AI022553 United States AI NIAID NIH HHS; R01 AR040312 United States AR NIAMS NIH HHS; R01 AR073252 United States AR NIAMS NIH HHS; R01 AR074302 United States AR NIAMS NIH HHS
المشرفين على المادة: 0 (IFNG protein, human)
0 (IL15 protein, human)
0 (Interleukin-15)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20200225 Date Completed: 20210401 Latest Revision: 20210903
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8223586
DOI: 10.1016/j.jid.2020.01.026
PMID: 32092350
قاعدة البيانات: MEDLINE
الوصف
تدمد:1523-1747
DOI:10.1016/j.jid.2020.01.026