دورية أكاديمية
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379.
| العنوان: | Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379. |
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| المؤلفون: | Berke JM; Janssen Research and Development, Beerse, Belgium jberke@its.jnj.com., Dehertogh P; Janssen Research and Development, Beerse, Belgium., Vergauwen K; Janssen Research and Development, Beerse, Belgium., Mostmans W; Janssen Research and Development, Beerse, Belgium., Vandyck K; Janssen Research and Development, Beerse, Belgium., Raboisson P; Janssen Research and Development, Beerse, Belgium., Pauwels F; Janssen Research and Development, Beerse, Belgium. |
| المصدر: | Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Apr 21; Vol. 64 (5). Date of Electronic Publication: 2020 Apr 21 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, American Society for Microbiology |
| مواضيع طبية MeSH: | Antiviral Agents/*pharmacology , Capsid/*drug effects , Hepatitis B virus/*drug effects , Organic Chemicals/*pharmacology, Capsid/ultrastructure ; Capsid Proteins/metabolism ; Cell Line ; DNA Replication/drug effects ; DNA, Viral/biosynthesis ; DNA, Viral/drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Hepatitis B/drug therapy ; Hepatitis B/virology ; Hepatitis B virus/ultrastructure ; Hepatocytes/virology ; Humans ; Microbial Sensitivity Tests ; Primary Cell Culture ; Virus Replication/drug effects |
| مستخلص: | Capsid assembly is a critical step in the hepatitis B virus (HBV) life cycle, mediated by the core protein. Core is a potential target for new antiviral therapies, the capsid assembly modulators (CAMs). JNJ-56136379 (JNJ-6379) is a novel and potent CAM currently in phase II trials. We evaluated the mechanisms of action (MOAs) and antiviral properties of JNJ-6379 in vitro Size exclusion chromatography and electron microscopy studies demonstrated that JNJ-6379 induced the formation of morphologically intact viral capsids devoid of genomic material (primary MOA). JNJ-6379 accelerated the rate and extent of HBV capsid assembly in vitro JNJ-6379 specifically and potently inhibited HBV replication; its median 50% effective concentration (EC (Copyright © 2020 American Society for Microbiology.) |
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| فهرسة مساهمة: | Keywords: capsid; capsid assembly modulator; cccDNA; hepatitis; hepatitis B virus; primary human hepatocytes |
| سلسلة جزيئية: | ClinicalTrials.gov NCT03361956 |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Capsid Proteins) 0 (DNA, Viral) 0 (JNJ-56136379) 0 (Organic Chemicals) |
| تواريخ الأحداث: | Date Created: 20200226 Date Completed: 20210405 Latest Revision: 20231103 |
| رمز التحديث: | 20231103 |
| مُعرف محوري في PubMed: | PMC7179615 |
| DOI: | 10.1128/AAC.02439-19 |
| PMID: | 32094138 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-6596 |
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| DOI: | 10.1128/AAC.02439-19 |