دورية أكاديمية
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Fish oil reverses metabolic syndrome, adipocyte dysfunction, and altered adipokines secretion triggered by high-fat diet-induced obesity.

التفاصيل البيبلوغرافية
العنوان: Fish oil reverses metabolic syndrome, adipocyte dysfunction, and altered adipokines secretion triggered by high-fat diet-induced obesity.
المؤلفون: da Cunha de Sá RDC; Post-graduate Program in Chemical Biology, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo -UNIFESP, Diadema, Sao Paulo, Brazil., Cruz MM; Post-graduate Program in Chemical Biology, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo -UNIFESP, Diadema, Sao Paulo, Brazil., de Farias TM; Post-graduate Program in Chemical Biology, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo -UNIFESP, Diadema, Sao Paulo, Brazil., da Silva VS; Post-graduate Program in Chemical Biology, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo -UNIFESP, Diadema, Sao Paulo, Brazil., de Jesus Simão J; Post-graduate Program in Chemical Biology, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo -UNIFESP, Diadema, Sao Paulo, Brazil., Telles MM; Post-graduate Program in Chemical Biology, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo -UNIFESP, Diadema, Sao Paulo, Brazil.; Department of Biological Sciences, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo - UNIFESP, Diadema, Sao Paulo, Brazil., Alonso-Vale MIC; Post-graduate Program in Chemical Biology, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo -UNIFESP, Diadema, Sao Paulo, Brazil.; Department of Biological Sciences, Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of Sao Paulo - UNIFESP, Diadema, Sao Paulo, Brazil.
المصدر: Physiological reports [Physiol Rep] 2020 Feb; Vol. 8 (4), pp. e14380.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
مواضيع طبية MeSH: Adipocytes/*metabolism , Fish Oils/*therapeutic use , Metabolic Syndrome/*drug therapy , Obesity/*etiology, Adipocytes/drug effects ; Adipokines/blood ; Adipokines/metabolism ; Animals ; Cells, Cultured ; Diet, High-Fat/adverse effects ; Fish Oils/administration & dosage ; Fish Oils/pharmacology ; Glucose/metabolism ; Lipolysis ; Male ; Metabolic Syndrome/etiology ; Mice ; Mice, Inbred C57BL ; Obesity/complications
مستخلص: The effect of fish oil (FO) treatment on high-fat (HF) diet-induced obesity and metabolic syndrome was addressed by analyzing dysfunctions in cells of different adipose depots. For this purpose, mice were initially induced to obesity for 8 weeks following a treatment with FO containing high concentration of EPA compared to DHA (5:1), for additional 8 weeks (by gavage, 3 times per week). Despite the higher fat intake, the HF group showed lower food intake but higher body weight, glucose intolerance and insulin resistance, significant dyslipidemia and increased liver, subcutaneous (inguinal-ING) and visceral (retroperitoneal-RP) adipose depots mass, accompanied by adipocyte hypertrophy and decreased cellularity in both adipose tissue depots. FO treatment reversed all these effects, as well as it improved the metabolic activities of isolated adipocytes, such as glucose uptake and lipolysis in both depots, and de novo synthesis of fatty acids in ING adipocytes. HF diet also significantly increased both the pro and anti-inflammatory cytokines expression by adipocytes, while HF + FO did not differ from control group. Collectively, these data show that the concomitant administration of FO with the HF diet is able to revert metabolic changes triggered by the diet-induced obesity, as well as to promote beneficial alterations in adipose cell activities. The main mechanism underlying all systemic effects involves direct and differential effects on ING and RP adipocytes.
(© 2020 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
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فهرسة مساهمة: Keywords: adipose tissue; cytokines; dyslipidemia; inflammation; insulin resistance; omega-3 fatty acids
المشرفين على المادة: 0 (Adipokines)
0 (Fish Oils)
IY9XDZ35W2 (Glucose)
تواريخ الأحداث: Date Created: 20200229 Date Completed: 20210101 Latest Revision: 20231113
رمز التحديث: 20231113
مُعرف محوري في PubMed: PMC7048378
DOI: 10.14814/phy2.14380
PMID: 32109344
قاعدة البيانات: MEDLINE
الوصف
تدمد:2051-817X
DOI:10.14814/phy2.14380