دورية أكاديمية
Toll-Interacting Protein Regulates Immune Cell Infiltration and Promotes Colitis-Associated Cancer.
العنوان: | Toll-Interacting Protein Regulates Immune Cell Infiltration and Promotes Colitis-Associated Cancer. |
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المؤلفون: | Begka C; Service of Gastroenterology and Hepatology, Department of Medicine, University Hospital of Lausanne, CHUV-Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland; University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland., Pattaroni C; Service of Pneumology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Chemin de Boveresses 155, 1066 Epalinges, Switzerland., Mooser C; Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland., Nancey S; Lyon Sud Hospital, Hospices Civils de Lyon, CHU, Lyon, France., McCoy KD; Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Velin D; Service of Gastroenterology and Hepatology, Department of Medicine, University Hospital of Lausanne, CHUV-Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland; University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland., Maillard MH; Service of Gastroenterology and Hepatology, Department of Medicine, University Hospital of Lausanne, CHUV-Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland; University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland; Crohn and Colitis Center, Gastroentérologie Beaulieu SA, Lausanne, Switzerland. Electronic address: michel.maillard@chuv.ch. |
مؤلفون مشاركون: | Swiss IBD Cohort Study Group |
المصدر: | IScience [iScience] 2020 Mar 27; Vol. 23 (3), pp. 100891. Date of Electronic Publication: 2020 Feb 08. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, [2018]- |
مستخلص: | Expression of Toll-interacting protein (Tollip), a potent TLR modulator, decreases in patients with inflammatory bowel diseases (IBD), whereas Tollip -/- mice are susceptible to colitis. Tollip expression was shown to be reduced in sporadic adenoma. In contrast, we found variable Tollip expression in patients with colitis-associated adenomas. In Tollip -/- mice challenged to develop colitis-associated cancer (CAC), tumor formation was significantly reduced owing to decreased mucosal proliferative and apoptotic indexes. This protection was associated with blunt inflammatory responses without significant changes in microbial composition. mRNA expression of Cd62l and Ccr5 homing receptors was reduced in colons of untreated Tollip -/- mice, whereas CD62L + CD8 + T cells accumulated in the periphery. In Tollip-deficient adenomas Ctla-4 mRNA expression and tumor-infiltrating CD4 + Foxp3 + regulatory T cell (Treg) were decreased. Our data show that protection from CAC in Tollip-deficient mice is associated with defects in lymphocyte accumulation and composition in colitis-associated adenomas. Competing Interests: Declaration of Interest The authors declare no conflicts of interest related to this study. (Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.) |
References: | Annu Rev Immunol. 2014;32:659-702. (PMID: 24655300) J Exp Med. 2010 Aug 2;207(8):1625-36. (PMID: 20624890) Gastroenterology. 2004 Apr;126(4):1054-70. (PMID: 15057745) J Clin Invest. 2008 Feb;118(2):560-70. (PMID: 18219394) Clin Microbiol Infect. 2006 Aug;12(8):782-6. (PMID: 16842574) PLoS One. 2010 Sep 27;5(9):e13027. (PMID: 20885960) Inflamm Bowel Dis. 2014 Apr;20(4):660-70. (PMID: 24572204) Gastroenterology. 2007 Dec;133(6):1869-81. (PMID: 18054559) Gastroenterology. 2004 Feb;126(2):451-9. (PMID: 14762782) J Gastroenterol. 2009;44(11):1097-108. (PMID: 19802731) Nat Rev Immunol. 2015 Oct;15(10):615-29. (PMID: 26358393) Cell. 2004 Aug 6;118(3):285-96. (PMID: 15294155) Nat Rev Immunol. 2016 May;16(5):295-309. (PMID: 27087661) Immunotherapy. 2015;7(6):655-67. (PMID: 26098609) Immunology. 2000 Oct;101(2):169-77. (PMID: 11012769) Cancer Cell. 2009 Feb 3;15(2):91-102. (PMID: 19185844) Oncogene. 2010 Jun 10;29(23):3313-23. (PMID: 20400974) Immunity. 2007 Apr;26(4):461-75. (PMID: 17398123) J Biol Chem. 2002 Mar 1;277(9):7059-65. (PMID: 11751856) Cancer Res. 2009 Oct 1;69(19):7884-92. (PMID: 19773434) Nat Cell Biol. 2000 Jun;2(6):346-51. (PMID: 10854325) Nat Rev Immunol. 2013 May;13(5):309-20. (PMID: 23598650) Clin Exp Immunol. 2016 Mar;183(3):358-68. (PMID: 26462859) J Clin Pathol. 2012 Apr;65(4):302-8. (PMID: 22228906) PLoS One. 2013 May 06;8(5):e62223. (PMID: 23671587) Exp Hematol. 2002 Mar;30(3):237-44. (PMID: 11882361) Sci Rep. 2016 Oct 05;6:34672. (PMID: 27703259) Cancer Res. 2014 Aug 15;74(16):4258-69. (PMID: 24906621) Curr Biol. 2006 Nov 21;16(22):2265-70. (PMID: 17113392) Semin Cancer Biol. 2012 Aug;22(4):327-34. (PMID: 22465232) Cell. 2004 Jul 23;118(2):229-41. (PMID: 15260992) Cancer Cell. 2016 May 9;29(5):684-696. (PMID: 27150039) Gut. 2005 Jul;54(7):950-4. (PMID: 15951540) J Immunol. 2003 Apr 15;170(8):3939-43. (PMID: 12682220) Science. 2007 Jul 6;317(5834):124-7. (PMID: 17615359) J Biol Chem. 2012 Nov 16;287(47):39653-63. (PMID: 23027871) Cancer Cell. 2016 Apr 11;29(4):587-601. (PMID: 27070705) PLoS One. 2009;4(2):e4404. (PMID: 19198660) Aliment Pharmacol Ther. 2006 Apr 15;23(8):1097-104. (PMID: 16611269) J Immunol. 2001 Jul 15;167(2):987-94. (PMID: 11441107) Hum Mol Genet. 2004 Apr 1;13(7):763-70. (PMID: 14976156) Genome Res. 2012 Feb;22(2):292-8. (PMID: 22009990) Inflamm Bowel Dis. 2016 Jul;22(7):1723-36. (PMID: 27271495) Cancer Immunol Immunother. 2011 Jul;60(7):909-18. (PMID: 21644034) Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G1055-65. (PMID: 15826931) Cancer Cell. 2013 Nov 11;24(5):631-44. (PMID: 24229710) |
فهرسة مساهمة: | Keywords: Biological Sciences; Cancer; Immunology |
تواريخ الأحداث: | Date Created: 20200302 Latest Revision: 20210110 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7049660 |
DOI: | 10.1016/j.isci.2020.100891 |
PMID: | 32114379 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2589-0042 |
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DOI: | 10.1016/j.isci.2020.100891 |