دورية أكاديمية
أعرض في EDS

Toll-Interacting Protein Regulates Immune Cell Infiltration and Promotes Colitis-Associated Cancer.

التفاصيل البيبلوغرافية
العنوان: Toll-Interacting Protein Regulates Immune Cell Infiltration and Promotes Colitis-Associated Cancer.
المؤلفون: Begka C; Service of Gastroenterology and Hepatology, Department of Medicine, University Hospital of Lausanne, CHUV-Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland; University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland., Pattaroni C; Service of Pneumology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Chemin de Boveresses 155, 1066 Epalinges, Switzerland., Mooser C; Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland., Nancey S; Lyon Sud Hospital, Hospices Civils de Lyon, CHU, Lyon, France., McCoy KD; Maurice Müller Laboratories (DBMR), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Velin D; Service of Gastroenterology and Hepatology, Department of Medicine, University Hospital of Lausanne, CHUV-Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland; University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland., Maillard MH; Service of Gastroenterology and Hepatology, Department of Medicine, University Hospital of Lausanne, CHUV-Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland; University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland; Crohn and Colitis Center, Gastroentérologie Beaulieu SA, Lausanne, Switzerland. Electronic address: michel.maillard@chuv.ch.
مؤلفون مشاركون: Swiss IBD Cohort Study Group
المصدر: IScience [iScience] 2020 Mar 27; Vol. 23 (3), pp. 100891. Date of Electronic Publication: 2020 Feb 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Expression of Toll-interacting protein (Tollip), a potent TLR modulator, decreases in patients with inflammatory bowel diseases (IBD), whereas Tollip -/- mice are susceptible to colitis. Tollip expression was shown to be reduced in sporadic adenoma. In contrast, we found variable Tollip expression in patients with colitis-associated adenomas. In Tollip -/- mice challenged to develop colitis-associated cancer (CAC), tumor formation was significantly reduced owing to decreased mucosal proliferative and apoptotic indexes. This protection was associated with blunt inflammatory responses without significant changes in microbial composition. mRNA expression of Cd62l and Ccr5 homing receptors was reduced in colons of untreated Tollip -/- mice, whereas CD62L + CD8 + T cells accumulated in the periphery. In Tollip-deficient adenomas Ctla-4 mRNA expression and tumor-infiltrating CD4 + Foxp3 + regulatory T cell (Treg) were decreased. Our data show that protection from CAC in Tollip-deficient mice is associated with defects in lymphocyte accumulation and composition in colitis-associated adenomas.
Competing Interests: Declaration of Interest The authors declare no conflicts of interest related to this study.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
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فهرسة مساهمة: Keywords: Biological Sciences; Cancer; Immunology
تواريخ الأحداث: Date Created: 20200302 Latest Revision: 20210110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7049660
DOI: 10.1016/j.isci.2020.100891
PMID: 32114379
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2020.100891