دورية أكاديمية
أعرض في EDS

A Dual Role for the Plasminogen Activator Protease During the Preinflammatory Phase of Primary Pneumonic Plague.

التفاصيل البيبلوغرافية
العنوان: A Dual Role for the Plasminogen Activator Protease During the Preinflammatory Phase of Primary Pneumonic Plague.
المؤلفون: Banerjee SK; University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, Little Rock, Arkansas, USA., Crane SD; University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, Little Rock, Arkansas, USA., Pechous RD; University of Arkansas for Medical Sciences, Department of Microbiology and Immunology, Little Rock, Arkansas, USA.
المصدر: The Journal of infectious diseases [J Infect Dis] 2020 Jul 06; Vol. 222 (3), pp. 407-416.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: Host-Pathogen Interactions*, Lung/*microbiology , Plague/*etiology , Plasminogen Activators/*physiology , Yersinia pestis/*metabolism, Animals ; Bacterial Adhesion ; Cytokines/metabolism ; Disease Models, Animal ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Virulence ; Yersinia pestis/pathogenicity
مستخلص: Early after inhalation, Yersinia pestis replicates to high numbers in the airways in the absence of disease symptoms or notable inflammatory responses to cause primary pneumonic plague. The plasminogen activator protease (Pla) is a critical Y. pestis virulence factor that is important for early bacterial growth in the lung via an unknown mechanism. In this article, we define a dual role for Pla in the initial stages of pulmonary infection. We show that Pla functions as an adhesin independent of its proteolytic function to suppress early neutrophil influx into the lungs, and that Pla enzymatic activity contributes to bacterial resistance to neutrophil-mediated bacterial killing. Our results suggest that the fate of Y. pestis infection of the lung is decided extremely early during infection and that Pla plays a dual role to tilt the balance in favor of the pathogen.
(© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
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معلومات مُعتمدة: P20 GM103625 United States GM NIGMS NIH HHS; P30 GM145393 United States GM NIGMS NIH HHS; R21 AI133103 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Yersinia pestis; Pla; plague; plasminogen activator protease; pneumonic plague
المشرفين على المادة: 0 (Cytokines)
EC 3.4.21.- (Plasminogen Activators)
تواريخ الأحداث: Date Created: 20200305 Date Completed: 20210216 Latest Revision: 20230217
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC7336565
DOI: 10.1093/infdis/jiaa094
PMID: 32128567
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiaa094