دورية أكاديمية
أعرض في EDS

Whey milk proteomics from Schistosoma mansoni-infected mice reveals proteins involved in immunomodulation of the offspring.

التفاصيل البيبلوغرافية
العنوان: Whey milk proteomics from Schistosoma mansoni-infected mice reveals proteins involved in immunomodulation of the offspring.
المؤلفون: de Holanda GCR; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., de Lima IL; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., Scapin SMN; Diretoria de Metrologia Aplicada às Ciências da Vida - DIMAV, Instituto Nacional de Metrologia, Qualidade e Tecnologia - INMETRO, Duque de Caxias, RJ, Brazil., Silva MDC; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., Sales IRF; Centro Universitário Maurício de Nassau, Recife, PE, Brazil., Granjeiro JM; Diretoria de Metrologia Aplicada às Ciências da Vida - DIMAV, Instituto Nacional de Metrologia, Qualidade e Tecnologia - INMETRO, Duque de Caxias, RJ, Brazil., da Silva RA; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., de Souza VMO; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil. valdenia.souza@gmail.com., de Lima Filho JL; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil.
المصدر: Parasitology research [Parasitol Res] 2020 May; Vol. 119 (5), pp. 1607-1617. Date of Electronic Publication: 2020 Mar 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer International, c1987-
مواضيع طبية MeSH: Antigens, Protozoan/*immunology , Immunomodulation/*immunology , Schistosoma mansoni/*immunology , Schistosomiasis/*immunology , Whey Proteins/*immunology, Animals ; B-Lymphocytes/immunology ; Complement Activation/immunology ; Female ; Gene Ontology ; Lymphocyte Activation/immunology ; Mass Spectrometry ; Mice ; Milk ; Phagocytosis/immunology ; Proteomics/methods ; Whey/metabolism ; Whey Proteins/analysis
مستخلص: Milk from schistosomotic mothers can modulate the immune response of their offspring. However, its characterization and potential of modulating immunity has not yet been fully elucidated. Thus, the aim of this study was to evaluate whey proteins from the milk of Schistosoma mansoni-infected mice in order to identify the fractions which can act as potential immunomodulatory tools. For this, we did a mass spectrometry (nanoUPLC-MSE) analysis to characterize the proteomic profile of milk from infected (MIM) and non-infected mice (MNIM). It was possible to identify 29 differentially expressed proteins: 15 were only found in MIM, 10 only found in MNIM, and 4 were downregulated in MIM group. Gene Ontology (GO), pathway enrichment analysis, and protein-protein interaction (PPI) analyses indicated differentially expressed proteins linked to biological processes and pathways in MIM group such as the following: fructose 1,6-biphosphate metabolic and glycolytic processes, glucose metabolism, and neutrophil degranulation pathways. The downregulated and unique proteins identified in MNIM group were involved in the positive regulation of B cell activation and receptor signaling pathway, in the innate immune response, complement activation, and phagocytosis. The present findings revealed a protein profile that may be involved in the activation and deactivation of the offspring's immune system in the long term, conferring a protective character due to the previous contact with milk from infected mothers.
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معلومات مُعتمدة: IBPG-0929-2.08/15 Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco
فهرسة مساهمة: Keywords: Breastfeeding; Immune response; Mass spectrometry; Offspring; Proteomics; Schistosomiasis
المشرفين على المادة: 0 (Antigens, Protozoan)
0 (Whey Proteins)
تواريخ الأحداث: Date Created: 20200306 Date Completed: 20200630 Latest Revision: 20210110
رمز التحديث: 20240628
DOI: 10.1007/s00436-020-06643-1
PMID: 32133541
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1955
DOI:10.1007/s00436-020-06643-1