دورية أكاديمية
Whey milk proteomics from Schistosoma mansoni-infected mice reveals proteins involved in immunomodulation of the offspring.
العنوان: | Whey milk proteomics from Schistosoma mansoni-infected mice reveals proteins involved in immunomodulation of the offspring. |
---|---|
المؤلفون: | de Holanda GCR; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., de Lima IL; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., Scapin SMN; Diretoria de Metrologia Aplicada às Ciências da Vida - DIMAV, Instituto Nacional de Metrologia, Qualidade e Tecnologia - INMETRO, Duque de Caxias, RJ, Brazil., Silva MDC; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., Sales IRF; Centro Universitário Maurício de Nassau, Recife, PE, Brazil., Granjeiro JM; Diretoria de Metrologia Aplicada às Ciências da Vida - DIMAV, Instituto Nacional de Metrologia, Qualidade e Tecnologia - INMETRO, Duque de Caxias, RJ, Brazil., da Silva RA; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil., de Souza VMO; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil. valdenia.souza@gmail.com., de Lima Filho JL; Laboratório de Imunopatologia Keizo Asami (LIKA), Universidade Federal de Pernambuco, Av. Moraes Rego, 1235 - Cidade Universitária, Recife, Pernambuco, 50670-901, Brazil. |
المصدر: | Parasitology research [Parasitol Res] 2020 May; Vol. 119 (5), pp. 1607-1617. Date of Electronic Publication: 2020 Mar 04. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1955 (Electronic) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1987- |
مواضيع طبية MeSH: | Antigens, Protozoan/*immunology , Immunomodulation/*immunology , Schistosoma mansoni/*immunology , Schistosomiasis/*immunology , Whey Proteins/*immunology, Animals ; B-Lymphocytes/immunology ; Complement Activation/immunology ; Female ; Gene Ontology ; Lymphocyte Activation/immunology ; Mass Spectrometry ; Mice ; Milk ; Phagocytosis/immunology ; Proteomics/methods ; Whey/metabolism ; Whey Proteins/analysis |
مستخلص: | Milk from schistosomotic mothers can modulate the immune response of their offspring. However, its characterization and potential of modulating immunity has not yet been fully elucidated. Thus, the aim of this study was to evaluate whey proteins from the milk of Schistosoma mansoni-infected mice in order to identify the fractions which can act as potential immunomodulatory tools. For this, we did a mass spectrometry (nanoUPLC-MSE) analysis to characterize the proteomic profile of milk from infected (MIM) and non-infected mice (MNIM). It was possible to identify 29 differentially expressed proteins: 15 were only found in MIM, 10 only found in MNIM, and 4 were downregulated in MIM group. Gene Ontology (GO), pathway enrichment analysis, and protein-protein interaction (PPI) analyses indicated differentially expressed proteins linked to biological processes and pathways in MIM group such as the following: fructose 1,6-biphosphate metabolic and glycolytic processes, glucose metabolism, and neutrophil degranulation pathways. The downregulated and unique proteins identified in MNIM group were involved in the positive regulation of B cell activation and receptor signaling pathway, in the innate immune response, complement activation, and phagocytosis. The present findings revealed a protein profile that may be involved in the activation and deactivation of the offspring's immune system in the long term, conferring a protective character due to the previous contact with milk from infected mothers. |
References: | Clin Exp Immunol. 2014 Sep;177(3):586-97. (PMID: 24749816) J Allergy Clin Immunol. 2014 Dec;134(6):1271-1279.e10. (PMID: 25042744) Mol Cell Biol. 2001 Nov;21(21):7207-17. (PMID: 11585904) Rev Inst Med Trop Sao Paulo. 1972 Nov-Dec;14(6):397-400. (PMID: 4675644) EMBO J. 2005 Feb 9;24(3):543-53. (PMID: 15660129) Int J Mol Med. 2016 Apr;37(4):1127-38. (PMID: 26935978) Am J Trop Med Hyg. 2003 Jun;68(6):647-51. (PMID: 12887021) Clin Diagn Lab Immunol. 2005 Jan;12(1):206-12. (PMID: 15643009) J Immunol. 2011 Mar 15;186(6):3299-303. (PMID: 21317389) Parasitol Res. 2010 Jun;107(1):95-102. (PMID: 20372927) Nat Med. 2012 Nov;18(11):1665-72. (PMID: 23104131) J Mammary Gland Biol Neoplasia. 2007 Mar;12(1):25-35. (PMID: 17431797) PLoS One. 2016 Mar 31;11(3):e0152165. (PMID: 27031837) Mol Biotechnol. 1997 Oct;8(2):155-67. (PMID: 9406186) Mem Inst Oswaldo Cruz. 2020 Feb 03;114:e190366. (PMID: 32022099) J Mol Med (Berl). 1998 Jul;76(8):581-8. (PMID: 9694435) Early Hum Dev. 2015 Nov;91(11):629-35. (PMID: 26375355) Mol Immunol. 2014 Jul;60(1):44-53. (PMID: 24747960) J Dairy Sci. 2015 Nov;98(11):7748-56. (PMID: 26298756) Cell Microbiol. 2004 Jan;6(1):13-22. (PMID: 14678327) Immunology. 2007 Sep;122(1):107-15. (PMID: 17608811) Rheumatology (Oxford). 2010 Sep;49(9):1618-31. (PMID: 20338884) J Leukoc Biol. 2005 Jul;78(1):85-94. (PMID: 15817708) Biochim Biophys Acta. 2000 Mar 7;1477(1-2):324-37. (PMID: 10708867) Rev Soc Bras Med Trop. 2018 Jul-Aug;51(4):546-549. (PMID: 30133643) J Proteome Res. 2009 Feb;8(2):1047-58. (PMID: 19152270) Mol Cell. 2009 Aug 14;35(3):316-26. (PMID: 19683495) Immunobiology. 2010;215(2):101-12. (PMID: 19457572) J Immunol. 2011 Nov 15;187(10):5440-51. (PMID: 22003197) Sci Rep. 2016 May 16;6:25747. (PMID: 27181051) Int J Gynaecol Obstet. 2013 Jul;122(1):1-4. (PMID: 23557896) Mem Inst Oswaldo Cruz. 2016 Feb;111(2):83-92. (PMID: 26872339) Springerplus. 2014 May 01;3:221. (PMID: 24877031) Front Cell Infect Microbiol. 2019 Apr 24;9:122. (PMID: 31069178) J Adv Res. 2013 Sep;4(5):433-44. (PMID: 25685450) Mol Cell Biol. 2000 May;20(9):3079-85. (PMID: 10757792) Parasitol Res. 2006 Jul;99(2):137-45. (PMID: 16521039) Sci Rep. 2017 Apr 06;7:45963. (PMID: 28382932) Exp Parasitol. 2014 Jun;141:62-7. (PMID: 24657585) Best Pract Res Clin Endocrinol Metab. 2018 Jan;32(1):47-56. (PMID: 29549959) J Nutr. 2011 Jun;141(6):1181-7. (PMID: 21508211) Proteomics. 2009 Mar;9(6):1696-719. (PMID: 19294629) Cell Signal. 2008 May;20(5):935-41. (PMID: 18294816) Pediatr Clin North Am. 2013 Feb;60(1):49-74. (PMID: 23178060) Adv Food Nutr Res. 2008;54:45-80. (PMID: 18291304) Breast Cancer Res. 2004;6(2):R75-91. (PMID: 14979920) Osteoarthritis Cartilage. 2004 Mar;12(3):239-44. (PMID: 14972341) Microbes Infect. 1999 Jun;1(7):517-24. (PMID: 10603568) |
معلومات مُعتمدة: | IBPG-0929-2.08/15 Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco |
فهرسة مساهمة: | Keywords: Breastfeeding; Immune response; Mass spectrometry; Offspring; Proteomics; Schistosomiasis |
المشرفين على المادة: | 0 (Antigens, Protozoan) 0 (Whey Proteins) |
تواريخ الأحداث: | Date Created: 20200306 Date Completed: 20200630 Latest Revision: 20210110 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s00436-020-06643-1 |
PMID: | 32133541 |
قاعدة البيانات: | MEDLINE |
كن أول من يترك تعليقا!