دورية أكاديمية
أعرض في EDS

Glucocorticoids delivered by inorganic-organic hybrid nanoparticles mitigate acute graft-versus-host disease and sustain graft-versus-leukemia activity.

التفاصيل البيبلوغرافية
العنوان: Glucocorticoids delivered by inorganic-organic hybrid nanoparticles mitigate acute graft-versus-host disease and sustain graft-versus-leukemia activity.
المؤلفون: Kaiser TK; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Li H; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Roßmann L; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Reichardt SD; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Bohnenberger H; Institute of Pathology, University Medical Center Göttingen, Göttingen, Germany., Feldmann C; Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany., Reichardt HM; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany.
المصدر: European journal of immunology [Eur J Immunol] 2020 Aug; Vol. 50 (8), pp. 1220-1233. Date of Electronic Publication: 2020 Mar 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005->: Weinheim : Wiley-VCH
Original Publication: Weinheim, Verlag Chemie GmbH.
مواضيع طبية MeSH: Betamethasone/*analogs & derivatives , Graft vs Host Disease/*drug therapy , Graft vs Leukemia Effect/*drug effects , Nanoparticles/*administration & dosage, Acute Disease ; Animals ; Betamethasone/administration & dosage ; Cytokines/blood ; Disease Models, Animal ; Intestine, Small/immunology ; Intestine, Small/pathology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myeloid Cells/drug effects
مستخلص: Glucocorticoids (GCs) are widely used to treat acute graft-versus-host disease (aGvHD) due to their immunosuppressive activity, but they also reduce the beneficial graft-versus-leukemia (GvL) effect of the allogeneic T cells contained in the graft. Here, we tested whether aGvHD therapy could be improved by delivering GCs with the help of inorganic-organic hybrid nanoparticles (IOH-NPs) that preferentially target myeloid cells. IOH-NPs containing the GC betamethasone (BMP-NPs) efficiently reduced morbidity, mortality, and tissue damage in a totally MHC mismatched mouse model of aGvHD. Therapeutic activity was lost in mice lacking the GC receptor (GR) in myeloid cells, confirming the cell type specificity of our approach. BMP-NPs had no relevant systemic activity but suppressed cytokine and chemokine gene expression locally in the small intestine, which presumably explains their mode of action. Most importantly, BMP-NPs delayed the development of an adoptively transferred B cell lymphoma better than the free drug, although the overall incidence was unaffected. Our findings thus suggest that employing IOH-NPs could diminish the risk of relapse associated with GC therapy of aGvHD patients while still allowing to efficiently ameliorate the disease.
(© 2020 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
References: Zeiser, R. and Blazar, B. R., Acute graft-versus-host disease - biologic process, prevention, and therapy. N. Engl. J. Med. 2017. 377: 2167-2179.
Hill, L., Alousi, A., Kebriaei, P., Mehta, R., Rezvani, K. and Shpall, E., New and emerging therapies for acute and chronic graft versus host disease. Ther. Adv. Hematol. 2018. 9: 21-46.
Pidala, J., Kim, J., Kharfan-Dabaja, M. A., Nishihori, T., Field, T., Perkins, J., Perez, L. et al., Dysglycemia following glucocorticoid therapy for acute graft-versus-host disease adversely affects transplantation outcomes. Biol. Blood Marrow Transplant. 2011. 17: 239-248.
Waddell, D. S., Baehr, L. M., van den Brandt, J., Johnsen, S. A., Reichardt, H. M., Furlow, J. D. and Bodine, S. C., The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am. J. Physiol. 2008. 295: E785-797.
Rauch, A., Seitz, S., Baschant, U., Schilling, A. F., Illing, A., Stride, B., Kirilov, M. et al., Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 2010. 11: 517-531.
Ferrara, J. L., Levine, J. E., Reddy, P. and Holler, E., Graft-versus-host disease. Lancet 2009. 373: 1550-1561.
Shlomchik, W. D., Graft-versus-host disease. Nat. Rev. Immunol. 2007. 7: 340-352.
Martin, P. J., Rizzo, J. D., Wingard, J. R., Ballen, K., Curtin, P. T., Cutler, C., Litzow, M. R. et al., First- and second-line systemic treatment of acute graft-versus-host disease: recommendations of the American Society of Blood and Marrow Transplantation. Biol. Blood Marrow Transplant. 2012. 18: 1150-1163.
Baake, T., Jörß, K., Suennemann, J., Roßmann, L., Bohnenberger, H., Tuckermann, J. P., Reichardt, H. M. et al., The glucocorticoid receptor in recipient cells keeps cytokine secretion in acute graft-versus-host disease at bay. Oncotarget 2018. 9: 15437-15450.
Theiss-Suennemann, J., Jörß, K., Messmann, J. J., Reichardt, S. D., Montes-Cobos, E., Lühder, F., Tuckermann, J. P. et al., Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells. J. Pathol. 2015. 235: 646-655.
Li, H., Kaiser, T. K., Borschiwer, M., Bohnenberger, H., Reichardt, S. D., Lühder, F., Walter, L. et al., Glucocorticoid resistance of allogeneic T cells alters the gene expression profile in the inflamed small intestine of mice suffering from acute graft-versus-host disease. J. Steroid Biochem. Mol. Biol. 2019: 105485.
Bouazzaoui, A., Spacenko, E., Mueller, G., Huber, E., Schubert, T., Holler, E., Andreesen, R. et al., Steroid treatment alters adhesion molecule and chemokine expression in experimental acute graft-vs.-host disease of the intestinal tract. Exp. Hematol. 2011. 39: 238-249.e231.
Lühder, F. and Reichardt, H. M., Novel drug delivery systems tailored for improved administration of glucocorticoids. Int. J. Mol. Sci. 2017. 18.
Kopecek, J., Polymer-drug conjugates: origins, progress to date and future directions. Adv. Drug Deliver. Rev. 2013. 65: 49-59.
Yuan, F., Quan, L. D., Cui, L., Goldring, S. R. and Wang, D., Development of macromolecular prodrug for rheumatoid arthritis. Adv. Drug Deliver. Rev. 2012. 64: 1205-1219.
Schweingruber, N., Haine, A., Tiede, K., Karabinskaya, A., van den Brandt, J., Wüst, S., Metselaar, J. M. et al., Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis. J. Immunol. 2011. 187: 4310-4318.
Schmidt, J., Metselaar, J. M., Wauben, M. H., Toyka, K. V., Storm, G. and Gold, R., Drug targeting by long-circulating liposomal glucocorticosteroids increases therapeutic efficacy in a model of multiple sclerosis. Brain 2003. 126: 1895-1904.
Zhao, C. Y., Fan, T. T., Yang, Y., Wu, M. L., Li, L., Zhou, Z., Jian, Y. L. et al., Preparation, macrophages targeting delivery and anti-inflammatory study of pentapeptide grafted nanostructured lipid carriers. Int. J. Pharmaceut. 2013. 450: 11-20.
Ren, K., Dusad, A., Yuan, F., Yuan, H. J., Purdue, P. E., Fehringer, E. V., Garvin, K. L. et al., Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects. J. Control Release 2014. 175: 1-9.
Ren, K., Yuan, H. J., Zhang, Y. J., Wei, X. and Wang, D., Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis. Clin. Immunol. 2015. 160: 71-81.
Jia, Z., Wang, X., Wei, X., Zhao, G., Foster, K. W., Qiu, F., Gao, Y. et al., Micelle-forming dexamethasone prodrug attenuates nephritis in lupus-prone mice without apparent glucocorticoid side effects. ACS Nano 2018. 12: 7663-7681.
Montes-Cobos, E., Ring, S., Fischer, H. J., Heck, J., Strauss, J., Schwaninger, M., Reichardt, S. D. et al., Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles. J. Control Release 2017. 245: 157-169.
Kaiser, T. K., Khorenko, M., Moussavi, A., Engelke, M., Boretius, S., Feldmann, C. and Reichardt, H. M., Highly selective organ distribution and cellular uptake of inorganic-organic hybrid nanoparticles customized for the targeted delivery of glucocorticoids. J. Control Release 2020. 319: 360-370.
Lee, S. J., Zahrieh, D., Agura, E., MacMillan, M. L., Maziarz, R. T., McCarthy, P. L., Jr., Ho, V. T. et al., Effect of up-front daclizumab when combined with steroids for the treatment of acute graft-versus-host disease: results of a randomized trial. Blood 2004. 104: 1559-1564.
Waldmann, T. A. and O'Shea, J., The use of antibodies against the IL-2 receptor in transplantation. Curr. Opin. Immunol. 1998. 10: 507-512.
Rech, A. J., Mick, R., Martin, S., Recio, A., Aqui, N. A., Powell, D. J., Jr., Colligon, T. A. et al., CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patients. Sci. Transl. Med. 2012. 4: 134ra162.
Hoffmann, P., Ermann, J., Edinger, M., Fathman, C. G. and Strober, S., Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 2002. 196: 389-399.
Cheng, J., Zhou, Y., Chen, B., Wang, J., Xia, G., Jin, N., Ding, J. et al., Prevention of acute graft-versus-host disease by magnetic nanoparticles of Fe(3)O(4) combined with cyclosporin A in murine models. Int. J. Nanomed. 2011. 6: 2183-2189.
Nishiwaki, S., Nakayama, T., Murata, M., Nishida, T., Terakura, S., Saito, S., Kato, T. et al., Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions. PLoS One 2014. 9: e96252.
Heck, J. G., Napp, J., Simonato, S., Mollmer, J., Lange, M., Reichardt, H. M., Staudt, R. et al., Multifunctional phosphate-based inorganic-organic hybrid nanoparticles. J. Am. Chem. Soc. 2015. 137: 7329-7336.
Neumeier, B. L., Khorenko, M., Alves, F., Goldmann, O., Napp, J., Schepers, U., Reichardt, H. M. et al., Fluorescent inorganic-organic hybrid nanoparticles. ChemNanoMat 2019. 5: 24-45.
Schweingruber, N., Fischer, H. J., Fischer, L., van den Brandt, J., Karabinskaya, A., Labi, V., Villunger, A. et al., Chemokine-mediated redirection of T cells constitutes a critical mechanism of glucocorticoid therapy in autoimmune CNS responses. Acta Neuropathol. 2014. 127: 713-729.
Wang, D., Müller, N., McPherson, K. G. and Reichardt, H. M., Glucocorticoids engage different signal transduction pathways to induce apoptosis in thymocytes and mature T cells. J. Immunol. 2006. 176: 1695-1702.
Wüst, S., van den Brandt, J., Tischner, D., Kleiman, A., Tuckermann, J. P., Gold, R., Lühder, F. et al., Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J. Immunol. 2008. 180: 8434-8443.
Warnke, R. A., Slavin, S., Coffman, R. L., Butcher, E. C., Knapp, M. R., Strober, S. and Weissman, I. L., The pathology and homing of a transplantable murine B cell leukemia (BCL1). J. Immunol. 1979. 123: 1181-1188.
Tutt, A. L., Stevenson, F. K., Slavin, S. and Stevenson, G. T., Secretion of idiotypic IgM by the mouse B-cell leukaemia (BCL1) occurs spontaneously in vitro and in vivo. Immunology 1985. 55: 59-63.
Beyersdorf, N., Ding, X., Hünig, T. and Kerkau, T., Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease. Blood 2009. 114: 4575-4582.
Kaplan, D. H., Anderson, B. E., McNiff, J. M., Jain, D., Shlomchik, M. J. and Shlomchik, W. D., Target antigens determine graft-versus-host disease phenotype. J. Immunol. 2004. 173: 5467-5475.
Meers, G. K., Bohnenberger, H., Reichardt, H. M., Lühder, F. and Reichardt, S. D., Impaired resolution of DSS-induced colitis in mice lacking the glucocorticoid receptor in myeloid cells. PLoS One 2018. 13: e0190846.
Cossarizza, A., Chang, H. D., Radbruch, A., Acs, A., Adam, D., Adam-Klages, S., Agace, W. W. et al., Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur. J. Immunol. 2019. 49: 1457-1973.
معلومات مُعتمدة: 1631/17-1 International Deutsche Forschungsgemeinschaft
فهرسة مساهمة: Keywords: glucocorticoids; graft-versus-host disease; graft-versus-leukemia effect; macrophages; nanoparticles
المشرفين على المادة: 0 (Cytokines)
7BK02SCL3W (betamethasone sodium phosphate)
9842X06Q6M (Betamethasone)
تواريخ الأحداث: Date Created: 20200306 Date Completed: 20201215 Latest Revision: 20201215
رمز التحديث: 20221213
DOI: 10.1002/eji.201948464
PMID: 32133644
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-4141
DOI:10.1002/eji.201948464