دورية أكاديمية
Medication association and immunomodulation: An approach in fungal diseases and in particular in the treatment of paracoccidioidomycosis.
| العنوان: | Medication association and immunomodulation: An approach in fungal diseases and in particular in the treatment of paracoccidioidomycosis. |
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| المؤلفون: | Santos LA; Microbiology and Immunology Department, Biomedical Sciences Institute, Federal University of Alfenas, Alfenas, MG, Brazil., Grisolia JC; Microbiology and Immunology Department, Biomedical Sciences Institute, Federal University of Alfenas, Alfenas, MG, Brazil., Malaquias LCC; Microbiology and Immunology Department, Biomedical Sciences Institute, Federal University of Alfenas, Alfenas, MG, Brazil., Paula FBA; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, MG, Brazil., Dias ALT; Microbiology and Immunology Department, Biomedical Sciences Institute, Federal University of Alfenas, Alfenas, MG, Brazil., Burger E; Microbiology and Immunology Department, Biomedical Sciences Institute, Federal University of Alfenas, Alfenas, MG, Brazil. Electronic address: eva.burger@unifal-mg.edu.br. |
| المصدر: | Acta tropica [Acta Trop] 2020 Jun; Vol. 206, pp. 105412. Date of Electronic Publication: 2020 Mar 02. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Basel. |
| مواضيع طبية MeSH: | Immunomodulation*, Antifungal Agents/*therapeutic use , Paracoccidioidomycosis/*drug therapy, Humans ; Immunotherapy ; Paracoccidioidomycosis/immunology |
| مستخلص: | Fungal infections have been increasing in recent decades, mainly affecting immunocompromised individuals, although certain mycoses, such as paracoccidioidomycosis (PCM), infect immunologically competent individuals. The major problems observed regarding fungal diseases are inadequate diagnosis, prolonged treatment time, the reduced number of drugs available for treatment, in addition to the fact that there are no vaccines for clinical use. Drug combination in order to immunomodulate the immune response is a new strategy used for the treatment of mycoses, since it is difficult to develop new antifungal drugs. The aim of this study is to present and analyze strategies recently suggested for the treatment of fungi of medical interest, in particular for PCM, such as the utilization of combinations of protein fractions or dead microorganisms, as vaccinal antigens, and cellular immunotherapy. We will also propose new therapeutic alternatives, such as lipids, vitamins, synthetic or natural products as well as the use of low intensity LASER therapy (LLLT) to modulate the immune response of the host, enhancing the efficiency of the existing treatments of mycoses of medical interest and in particular of PCM. Competing Interests: Declaration of Competing Interest None. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Fungal diseases; Immunomodulation; Medication association |
| المشرفين على المادة: | 0 (Antifungal Agents) |
| تواريخ الأحداث: | Date Created: 20200306 Date Completed: 20200918 Latest Revision: 20200918 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.actatropica.2020.105412 |
| PMID: | 32135141 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6254 |
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| DOI: | 10.1016/j.actatropica.2020.105412 |