دورية أكاديمية
أعرض في EDS

Patterns and predictors of co-morbidities in Tuberculosis: A cross-sectional study in the Philippines.

التفاصيل البيبلوغرافية
العنوان: Patterns and predictors of co-morbidities in Tuberculosis: A cross-sectional study in the Philippines.
المؤلفون: White LV; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan., Edwards T; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.; Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK., Lee N; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.; Royal Free Hospital, London, UK., Castro MC; Nutrition Center Philippines, Manila, The Philippines., Saludar NR; San Lazaro Hospital, Manila, The Philippines., Calapis RW; San Lazaro Hospital PMDT Treatment Center, Manila, The Philippines., Faguer BN; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan., Fuente ND; Valladolid Health Center, Valladolid, Negros Occidental, The Philippines., Mayoga F; Bago City Health Center, Bago City, Negros Occidental, The Philippines., Saito N; Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan., Ariyoshi K; Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan., Garfin AMCG; National TB Control Programme, Department of Health, Manila, The Philippines., Solon JA; Nutrition Center Philippines, Manila, The Philippines., Cox SE; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. Sharon.Cox@LSHTM.AC.UK.; Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan. Sharon.Cox@LSHTM.AC.UK.; Faculty of Population Health, London School of Hygiene and Tropical Medicine, London, UK. Sharon.Cox@LSHTM.AC.UK.
المصدر: Scientific reports [Sci Rep] 2020 Mar 05; Vol. 10 (1), pp. 4100. Date of Electronic Publication: 2020 Mar 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Diabetes Complications/*epidemiology , Tuberculosis/*epidemiology, Adult ; Aged ; Comorbidity ; Cross-Sectional Studies ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Multimorbidity ; Obesity/complications ; Obesity/epidemiology ; Philippines/epidemiology ; Prevalence ; Young Adult
مستخلص: Diabetes and undernutrition are common risk factors for TB, associated with poor treatment outcomes and exacerbated by TB. We aimed to assess non-communicable multimorbidity (co-occurrence of two or more medical conditions) in Filipino TB outpatients, focusing on malnutrition and diabetes. In a cross-sectional study, 637 adults (70% male) from clinics in urban Metro Manila (N = 338) and rural Negros Occidental (N = 299) were enrolled. Diabetes was defined as HbA1c of ≥6.5% and/or current diabetes medication. Study-specific HIV screening was conducted. The prevalence of diabetes was 9.2% (54/589, 95%CI: 7.0-11.8%) with 52% newly diagnosed. Moderate/severe undernutrition (body mass index (BMI) <17 kg/ 2 ) was 20.5% (130/634, 95%CI: 17.4-23.9%). Forty percent of participants had at least one co-morbidity (diabetes, moderate/severe undernutrition or moderate/severe anaemia (haemoglobin <11 g/dL)). HIV infection (24.4%, 74/303) was not associated with other co-morbidities (but high refusal in rural clinics). Central obesity assessed by waist-to-hip ratio was more strongly associated with diabetes (Adjusted Odds Ratio (AOR) = 6.16, 95%CI: 3.15-12.0) than BMI. Undernutrition was less common in men (AOR = 0.44, 95%CI: 0.28-0.70), and associated with previous history of TB (AOR = 1.97, 95%CI: 1.28-3.04) and recent reduced food intake. The prevalence of multimorbidity was high demonstrating a significant unmet need. HIV was not a risk factor for increased non-communicable multimorbidity.
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معلومات مُعتمدة: MR/R010161/1 United Kingdom MRC_ Medical Research Council
تواريخ الأحداث: Date Created: 20200307 Date Completed: 20201126 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC7058028
DOI: 10.1038/s41598-020-60942-2
PMID: 32139742
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-60942-2