دورية أكاديمية
Zinc Supplementation: Immune Balance of Pregnancy During the Chronic Phase of the Chagas Disease.
| العنوان: | Zinc Supplementation: Immune Balance of Pregnancy During the Chronic Phase of the Chagas Disease. |
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| المؤلفون: | Bronzon da Costa CM; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil. marianabronzon@gmail.com., Del Vecchio Filipin M; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil., Santello FH; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil., Gallo IFL; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil., Pereira LM; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil., Barbosa F Jr; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil., do Prado Júnior JC; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil., Abrahão AAC; Department of Clinical Analysis, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-903, Brazil. acarraro@fcfrp.usp.br. |
| المصدر: | Acta parasitologica [Acta Parasitol] 2020 Sep; Vol. 65 (3), pp. 599-609. Date of Electronic Publication: 2020 Mar 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 9301947 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1896-1851 (Electronic) Linking ISSN: 12302821 NLM ISO Abbreviation: Acta Parasitol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : Cham : Springer International Publishing Original Publication: Warszawa : Witold Stefanski Institute Of Parasitology |
| مواضيع طبية MeSH: | Dietary Supplements*, Chagas Disease/*drug therapy , Chagas Disease/*immunology , Pregnancy Complications, Infectious/*drug therapy , Trypanosoma cruzi/*drug effects , Zinc/*therapeutic use, Animals ; Chronic Disease ; Female ; Pregnancy ; Pregnancy Complications, Infectious/parasitology ; Rats ; Rats, Wistar |
| مستخلص: | Background: Chagas disease or American trypanosomiasis is caused by the protozoan Trypanosoma cruzi and is endemic of the Americas. The control of the disease is restricted to toxic and potentially teratogenic drugs, which limit the use during pregnancy. The use of food supplementation offers a safe and low-cost form to alleviate Chagas disease symptoms, mostly in areas with alimentary risk. For example, zinc demonstrates positive effects in immune response, including in Chagas disease during pregnancy. Purpose: This study describes the innate response in pregnant rats chronically infected with T. cruzi and supplemented with zinc. Methods: Pregnant female Wistar rats, infected with T. cruzi, were treated with 20 mg/kg/day zinc sulfate and euthanized on the 18th day. Samples (plasma, splenocytes, and peritoneal exudate) were collected and several immune parameters (nitric oxide, RT1B, CD80/CD86, MCP-1, CD11b/c, NK/NKT, IL-2, IL-10, INF-cc, and apoptosis) evaluated. Results: Under Zinc supplementation and/or T. cruzi infection, the gestation developed normally. Several innate immune parameters such as RT1B, CD80/CD86, MCP-1 expressing lymphocytes, IL-2, and IL-17 were positively altered, whereas nitric oxide, CD11b/c, NK/NKT, apoptosis, INF-γ, and corticosterone demonstrated a pro-pregnancy pattern. Conclusion: Our results indicated that zinc has diverse effects on immune response during pregnancy. An anti-T. cruzi immunity, as well as a pro-gestation response, were observed after zinc supplementation. The complete comprehension of zinc supplementation in pregnancy will base an adequate strategy to alleviate Chagas disease symptoms and propagation, especially for populations from endemic areas. |
| معلومات مُعتمدة: | 2013/04205-6 FAPESP |
| فهرسة مساهمة: | Keywords: Chagas disease; Chronic phase; Pregnancy; Zinc |
| المشرفين على المادة: | J41CSQ7QDS (Zinc) |
| تواريخ الأحداث: | Date Created: 20200307 Date Completed: 20210602 Latest Revision: 20210602 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2478/s11686-020-00188-0 |
| PMID: | 32141022 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1896-1851 |
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| DOI: | 10.2478/s11686-020-00188-0 |