دورية أكاديمية
Overview of mathematical modeling of myocardial blood flow regulation.
العنوان: | Overview of mathematical modeling of myocardial blood flow regulation. |
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المؤلفون: | Namani R; Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan., Lanir Y; Faculty of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel., Lee LC; Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan., Kassab GS; The California Medical Innovations Institute Incorporated, San Diego, California. |
المصدر: | American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2020 Apr 01; Vol. 318 (4), pp. H966-H975. Date of Electronic Publication: 2020 Mar 06. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
اللغة: | English |
بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society, |
مواضيع طبية MeSH: | Coronary Circulation* , Homeostasis* , Models, Cardiovascular*, Heart/*physiology, Hemodynamics ; Humans ; Myocardial Contraction |
مستخلص: | The oxygen consumption by the heart and its extraction from the coronary arterial blood are the highest among all organs. Any increase in oxygen demand due to a change in heart metabolic activity requires an increase in coronary blood flow. This functional requirement of adjustment of coronary blood flow is mediated by coronary flow regulation to meet the oxygen demand without any discomfort, even under strenuous exercise conditions. The goal of this article is to provide an overview of the theoretical and computational models of coronary flow regulation and to reveal insights into the functioning of a complex physiological system that affects the perfusion requirements of the myocardium. Models for three major control mechanisms of myogenic, flow, and metabolic control are presented. These explain how the flow regulation mechanisms operating over multiple spatial scales from the precapillaries to the large coronary arteries yield the myocardial perfusion characteristics of flow reserve, autoregulation, flow dispersion, and self-similarity. The review not only introduces concepts of coronary blood flow regulation but also presents state-of-the-art advances and their potential to impact the assessment of coronary microvascular dysfunction (CMD), cardiac-coronary coupling in metabolic diseases, and therapies for angina and heart failure. Experimentalists and modelers not trained in these models will have exposure through this review such that the nonintuitive and highly nonlinear behavior of coronary physiology can be understood from a different perspective. This survey highlights knowledge gaps, key challenges, future research directions, and novel paradigms in the modeling of coronary flow regulation. |
References: | Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H517-28. (PMID: 24363304) Am J Physiol. 1997 Mar;272(3 Pt 2):H1516-26. (PMID: 9087630) Circ Res. 1985 Aug;57(2):285-95. (PMID: 4017198) Int J Numer Method Biomed Eng. 2018 Oct;34(10):e3123. (PMID: 29947132) Compr Physiol. 2017 Mar 16;7(2):321-382. (PMID: 28333376) Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2224-37. (PMID: 12003832) Am J Physiol. 1991 Apr;260(4 Pt 2):H1276-82. (PMID: 1707243) Am J Physiol Heart Circ Physiol. 2000 May;278(5):H1490-9. (PMID: 10775126) Microvasc Res. 1992 Mar;43(2):156-77. (PMID: 1584059) J Heart Transplant. 1985 Feb;4(2):241-6. (PMID: 3916494) J Am Coll Cardiol. 1991 Jun;17(7):1461-70. (PMID: 2033177) J Biomech Eng. 2011 Sep;133(9):094506. (PMID: 22010752) Am J Physiol. 1999 Jul;277(1):H183-91. (PMID: 10409196) Am J Cardiol. 1974 Jan;33(1):87-94. (PMID: 4808557) Med Biol Eng Comput. 2008 May;46(5):411-9. (PMID: 18365262) Med Eng Phys. 2003 Oct;25(8):691-709. (PMID: 12900184) J Biomech Eng. 1985 Feb;107(1):2-9. (PMID: 3884895) Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1683-94. (PMID: 27037372) Physiol Rev. 1983 Jan;63(1):1-205. (PMID: 6296890) Circulation. 2017 Feb 7;135(6):566-577. (PMID: 27881570) Biophys J. 2009 May 20;96(10):4035-43. (PMID: 19450475) Cardiovasc Res. 1996 Oct;32(4):668-78. (PMID: 8915185) Biophys J. 2008 Sep 15;95(6):2728-38. (PMID: 18586845) Med Biol Eng Comput. 2013 Jul;51(7):729-39. (PMID: 23605057) Am J Physiol. 1997 Apr;272(4 Pt 2):H1571-81. (PMID: 9139938) Front Physiol. 2018 May 23;9:580. (PMID: 29875686) Circulation. 1995 Aug 1;92(3):518-25. (PMID: 7543382) Math Biosci. 1994 Feb;119(2):127-67. (PMID: 8142694) J Am Coll Cardiol. 2006 Mar 21;47(6):1188-95. (PMID: 16545651) Crit Rev Biomed Eng. 1989;17(3):257-321. (PMID: 2673661) Cardiovasc Res. 2020 Mar 1;116(4):756-770. (PMID: 31926020) Circ Res. 1975 Jun;36(6):753-60. (PMID: 1132069) Microcirculation. 2013 Feb;20(2):117-37. (PMID: 23025284) Basic Res Cardiol. 2018 Aug 3;113(5):34. (PMID: 30074094) Microcirculation. 2012 Feb;19(2):99-114. (PMID: 21895845) Front Physiol. 2012 Jul 16;3:246. (PMID: 22934004) Circ Res. 1993 Aug;73(2):252-63. (PMID: 8392446) Free Radic Biol Med. 2006 Aug 15;41(4):668-80. (PMID: 16864000) Am J Physiol Cell Physiol. 2007 Jul;293(1):C277-93. (PMID: 17459942) J Appl Physiol (1985). 2020 May 1;128(5):1106-1122. (PMID: 32078466) Circulation. 1999 Jul 6;100(1):75-81. (PMID: 10393684) Biophys J. 2012 Mar 21;102(6):1352-62. (PMID: 22455918) J Biomech Eng. 1985 Feb;107(1):51-6. (PMID: 3981986) Physiol Rev. 1990 Apr;70(2):331-90. (PMID: 2181499) Acta Physiol Scand. 2000 Apr;168(4):551-9. (PMID: 10759592) Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1562-71. (PMID: 18689501) Circulation. 1995 Feb 1;91(3):635-40. (PMID: 7828287) Circ Res. 1992 Nov;71(5):1200-12. (PMID: 1394880) J Am Coll Cardiol. 2018 Nov 27;72(21):2642-2662. (PMID: 30466522) Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1572-9. (PMID: 18723769) Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H331-43. (PMID: 21572020) Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1598-603. (PMID: 15550516) Ann Biomed Eng. 1994 Nov-Dec;22(6):638-52. (PMID: 7872573) J Am Coll Cardiol. 2018 Mar 6;71(9):969-979. (PMID: 29495996) Med Eng Phys. 2003 Oct;25(8):711-7. (PMID: 12900185) J Am Coll Cardiol. 1990 Feb;15(2):459-74. (PMID: 2137151) Am J Physiol. 1989 Feb;256(2 Pt 2):H383-90. (PMID: 2492768) Physiol Meas. 2004 Aug;25(4):863-77. (PMID: 15382827) Circ Res. 1990 Mar;66(3):860-6. (PMID: 2306810) Circ Res. 1981 Sep;49(3):584-93. (PMID: 7261259) Nat Rev Cardiol. 2015 Jan;12(1):48-62. (PMID: 25311229) Am J Physiol. 1993 Jul;265(1 Pt 2):H350-65. (PMID: 8342652) Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H11-23. (PMID: 27199135) Physiol Rev. 2006 Oct;86(4):1263-308. (PMID: 17015490) Am J Physiol. 1997 Jun;272(6 Pt 2):H2963-75. (PMID: 9227575) Basic Res Cardiol. 1995 Mar-Apr;90(2):112-8. (PMID: 7646415) J Biomech Eng. 1996 May;118(2):145-51. (PMID: 8738777) Exp Biol Med (Maywood). 2012 Jun;237(6):644-51. (PMID: 22715433) Prog Biophys Mol Biol. 1998;69(2-3):463-81. (PMID: 9785951) Am J Physiol. 1995 Feb;268(2 Pt 2):H895-908. (PMID: 7864217) Am J Physiol. 1990 Jan;258(1 Pt 2):H262-76. (PMID: 2301610) Circ Res. 1990 Aug;67(2):319-31. (PMID: 2376074) Front Physiol. 2018 Aug 29;9:1069. (PMID: 30210353) Circ Res. 1972 Jan;30(1):67-81. (PMID: 5007529) J Gen Physiol. 2018 Jan 2;150(1):145-168. (PMID: 29196421) Microcirculation. 2005 Jun;12(4):327-38. (PMID: 16020079) Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H439-46. (PMID: 15792992) Front Physiol. 2018 Mar 02;9:119. (PMID: 29551977) J Vasc Res. 1998 Mar-Apr;35(2):85-92. (PMID: 9588871) Physiol Rev. 2008 Jul;88(3):1009-86. (PMID: 18626066) Cardiovasc Res. 1995 May;29(5):585-96. (PMID: 7606744) Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2432-8. (PMID: 16428352) J Theor Biol. 2008 Jul 21;253(2):238-60. (PMID: 18423672) J Physiol. 1919 May 20;52(6):457-74. (PMID: 16993410) Circ Cardiovasc Imaging. 2017 Aug;10(8):. (PMID: 28794138) Microcirculation. 2008 Nov;15(8):765-75. (PMID: 18951240) Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H1090-100. (PMID: 21169398) Am J Physiol. 1992 Aug;263(2 Pt 2):H447-52. (PMID: 1510143) Ann Biomed Eng. 2006 Dec;34(12):1833-45. (PMID: 17048105) J Am Coll Cardiol. 2018 Nov 27;72(21):2625-2641. (PMID: 30466521) Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2230-42. (PMID: 22408024) Basic Res Cardiol. 1990;85 Suppl 1:111-20. (PMID: 1982606) Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H861-73. (PMID: 19966048) J Gen Physiol. 2003 Sep;122(3):307-21. (PMID: 12913088) Am J Physiol. 1994 Jun;266(6 Pt 2):H2542-53. (PMID: 8024017) Circulation. 2019 Nov 26;140(22):1805-1816. (PMID: 31707835) Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H52-65. (PMID: 19855062) J Vasc Res. 2000 Jul-Aug;37(4):282-96. (PMID: 10965227) Am J Physiol. 1995 Dec;269(6 Pt 2):H2022-30. (PMID: 8594912) |
معلومات مُعتمدة: | 17SDG33370110 United States AHA American Heart Association-American Stroke Association; R01 HL134841 United States HL NHLBI NIH HHS; U01 HL133359 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: cardiac coronary coupling; coronary flow regulation; diagnostic potential; physiological mechanisms |
تواريخ الأحداث: | Date Created: 20200307 Date Completed: 20200525 Latest Revision: 20220129 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7191499 |
DOI: | 10.1152/ajpheart.00563.2019 |
PMID: | 32142361 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1522-1539 |
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DOI: | 10.1152/ajpheart.00563.2019 |