دورية أكاديمية
Overview of mathematical modeling of myocardial blood flow regulation.
| العنوان: | Overview of mathematical modeling of myocardial blood flow regulation. |
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| المؤلفون: | Namani R; Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan., Lanir Y; Faculty of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel., Lee LC; Department of Mechanical Engineering, Michigan State University, East Lansing, Michigan., Kassab GS; The California Medical Innovations Institute Incorporated, San Diego, California. |
| المصدر: | American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2020 Apr 01; Vol. 318 (4), pp. H966-H975. Date of Electronic Publication: 2020 Mar 06. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society, |
| مواضيع طبية MeSH: | Coronary Circulation* , Homeostasis* , Models, Cardiovascular*, Heart/*physiology, Hemodynamics ; Humans ; Myocardial Contraction |
| مستخلص: | The oxygen consumption by the heart and its extraction from the coronary arterial blood are the highest among all organs. Any increase in oxygen demand due to a change in heart metabolic activity requires an increase in coronary blood flow. This functional requirement of adjustment of coronary blood flow is mediated by coronary flow regulation to meet the oxygen demand without any discomfort, even under strenuous exercise conditions. The goal of this article is to provide an overview of the theoretical and computational models of coronary flow regulation and to reveal insights into the functioning of a complex physiological system that affects the perfusion requirements of the myocardium. Models for three major control mechanisms of myogenic, flow, and metabolic control are presented. These explain how the flow regulation mechanisms operating over multiple spatial scales from the precapillaries to the large coronary arteries yield the myocardial perfusion characteristics of flow reserve, autoregulation, flow dispersion, and self-similarity. The review not only introduces concepts of coronary blood flow regulation but also presents state-of-the-art advances and their potential to impact the assessment of coronary microvascular dysfunction (CMD), cardiac-coronary coupling in metabolic diseases, and therapies for angina and heart failure. Experimentalists and modelers not trained in these models will have exposure through this review such that the nonintuitive and highly nonlinear behavior of coronary physiology can be understood from a different perspective. This survey highlights knowledge gaps, key challenges, future research directions, and novel paradigms in the modeling of coronary flow regulation. |
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| معلومات مُعتمدة: | 17SDG33370110 United States AHA American Heart Association-American Stroke Association; R01 HL134841 United States HL NHLBI NIH HHS; U01 HL133359 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: cardiac coronary coupling; coronary flow regulation; diagnostic potential; physiological mechanisms |
| تواريخ الأحداث: | Date Created: 20200307 Date Completed: 20200525 Latest Revision: 20220129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7191499 |
| DOI: | 10.1152/ajpheart.00563.2019 |
| PMID: | 32142361 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1539 |
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| DOI: | 10.1152/ajpheart.00563.2019 |