دورية أكاديمية
Optogenetic approaches to investigate spatiotemporal signaling during development.
| العنوان: | Optogenetic approaches to investigate spatiotemporal signaling during development. |
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| المؤلفون: | Rogers KW; Systems Biology of Development Group, Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany., Müller P; Systems Biology of Development Group, Friedrich Miescher Laboratory of the Max Planck Society, Tübingen, Germany; Modeling Tumorigenesis Group, Translational Oncology Division, Eberhard Karls University Tübingen, Tübingen, Germany. Electronic address: patrick.mueller@tuebingen.mpg.de. |
| المصدر: | Current topics in developmental biology [Curr Top Dev Biol] 2020; Vol. 137, pp. 37-77. Date of Electronic Publication: 2019 Dec 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0163114 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8933 (Electronic) Linking ISSN: 00702153 NLM ISO Abbreviation: Curr Top Dev Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : New York Ny : Elsevier Original Publication: New York, London, Academic Press. |
| مواضيع طبية MeSH: | Developmental Biology* , Embryonic Development* , Gene Expression Regulation, Developmental* , Optogenetics* , Spatio-Temporal Analysis*, Animals ; Cell Differentiation ; Cell Proliferation ; Humans ; Signal Transduction |
| مستخلص: | Embryogenesis is coordinated by signaling pathways that pattern the developing organism. Many aspects of this process are not fully understood, including how signaling molecules spread through embryonic tissues, how signaling amplitude and dynamics are decoded, and how multiple signaling pathways cooperate to pattern the body plan. Optogenetic approaches can be used to address these questions by providing precise experimental control over a variety of biological processes. Here, we review how these strategies have provided new insights into developmental signaling and discuss how they could contribute to future investigations. (© 2020 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Embryogenesis; Optogenetics; Pattern formation; Signaling; Spatiotemporal dynamics |
| تواريخ الأحداث: | Date Created: 20200308 Date Completed: 20210603 Latest Revision: 20210603 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/bs.ctdb.2019.11.009 |
| PMID: | 32143750 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-8933 |
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| DOI: | 10.1016/bs.ctdb.2019.11.009 |