دورية أكاديمية
Changes in cardiac biomarkers in goats naturally affected by pregnancy toxemia.
| العنوان: | Changes in cardiac biomarkers in goats naturally affected by pregnancy toxemia. |
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| المؤلفون: | Souza LM; Federal Rural University of Pernambuco (UAG/UFRPE), Postgraduate Program in Sanitation and Reproduction of Ruminants, Av. Bom Pastor, s/n, CP 152-Boa Vista, 55292-278 Garanhuns, Pernambuco, Brazil. Electronic address: leonardomagnovet@hotmail.com., Mendonça CL; Cattle Clinic, Campus Garanhuns/UFRPE, Av. Bom Pastor, s/n, CP 152-Boa Vista, 55292-278 Garanhuns, Pernambuco, Brazil., Assis RN; Federal Rural University of Pernambuco (UAG/UFRPE), Postgraduate Program in Sanitation and Reproduction of Ruminants, Av. Bom Pastor, s/n, CP 152-Boa Vista, 55292-278 Garanhuns, Pernambuco, Brazil., Oliveira Filho EF; Federal Rural University of Pernambuco, Postgraduate Program in Veterinary Medicine, Campus Recife/UFRPE, Av. Manuel de Medeiros, s/n-Dois Irmãos, 52171-900 Recife, Pernambuco, Brazil., Soares GSL; Federal Rural University of Pernambuco, Postgraduate Program in Veterinary Medicine, Campus Recife/UFRPE, Av. Manuel de Medeiros, s/n-Dois Irmãos, 52171-900 Recife, Pernambuco, Brazil., Souto RJC; Cattle Clinic, Campus Garanhuns/UFRPE, Av. Bom Pastor, s/n, CP 152-Boa Vista, 55292-278 Garanhuns, Pernambuco, Brazil., Soares PC; Department of Veterinary Medicine, Campus Recife/UFRPE, Av. Manuel de Medeiros, s/n-Dois Irmãos, 52171-900 Recife, Pernambuco, Brazil., Afonso JAB; Cattle Clinic, Campus Garanhuns/UFRPE, Av. Bom Pastor, s/n, CP 152-Boa Vista, 55292-278 Garanhuns, Pernambuco, Brazil. |
| المصدر: | Research in veterinary science [Res Vet Sci] 2020 Jun; Vol. 130, pp. 73-78. Date of Electronic Publication: 2020 Feb 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: British Veterinary Association Country of Publication: England NLM ID: 0401300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2661 (Electronic) Linking ISSN: 00345288 NLM ISO Abbreviation: Res Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : British Veterinary Association Original Publication: Oxford. |
| مواضيع طبية MeSH: | Biomarkers/*metabolism , Goat Diseases/*metabolism , Myocardium/*metabolism , Pre-Eclampsia/*veterinary, Animals ; Female ; Goats ; Pre-Eclampsia/metabolism ; Pregnancy ; Toxemia/metabolism ; Toxemia/veterinary |
| مستخلص: | Pregnancy toxemia (PT) is considered one of the most common metabolic diseases with high impact on the production of small ruminants. The objective of this study was investigate possible myocardial damage in goats affected with PT by the determination of serum myocardial biomarkers CK-MB and cTnI. A total of 44 goats affected with PT, and 10 apparently healthy goats (control group or CG) were used in the study. In goats with PT, the serum concentrations of cTnI (0.43 ng/mL) were significantly higher than that in CG goats (0.06 ng/mL). Although CK-MB showed no significant difference, it was approximately three times higher in animals with PT. The serum concentrations of insulin were significantly lower in PT goats (5.03 ppmol/L) compared to CG goats (10.66 pmol/L). The serum concentrations of cortisol in PT goats (155.41 nmol/L) were significantly higher than that in CG goats (36.58 nmol/L). Results of this study indicate that a clinically significant myocardial damage might occur in goats affected with PT leading to significant elevations in values of cTnI and CK-MB. Therefore, these parameters could be used as a potential prognostic indicator in goats affected with this important disease. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest. (Copyright © 2020 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cardiac injury; Clinical biochemistry; Goat; Metabolic disorders; Pregnancy toxemia |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20200309 Date Completed: 20200827 Latest Revision: 20200827 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.rvsc.2020.02.016 |
| PMID: | 32146378 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1532-2661 |
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| DOI: | 10.1016/j.rvsc.2020.02.016 |