دورية أكاديمية
Vitamin C and E supplementation does not affect heat shock proteins or endogenous antioxidants in trained skeletal muscles during 12 weeks of strength training.
العنوان: | Vitamin C and E supplementation does not affect heat shock proteins or endogenous antioxidants in trained skeletal muscles during 12 weeks of strength training. |
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المؤلفون: | Cumming KT; 1Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway., Raastad T; 1Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway., Sørstrøm A; 1Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway., Paronetto MP; 2Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', Rome, Italy., Mercatelli N; 2Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', Rome, Italy., Ugelstad I; 1Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway., Caporossi D; 2Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', Rome, Italy., Paulsen G; 1Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.; Norwegian Olympic Sports Center, Oslo, Norway. |
المصدر: | BMC nutrition [BMC Nutr] 2017 Aug 17; Vol. 3, pp. 70. Date of Electronic Publication: 2017 Aug 17 (Print Publication: 2017). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101672434 Publication Model: eCollection Cited Medium: Internet ISSN: 2055-0928 (Electronic) Linking ISSN: 20550928 NLM ISO Abbreviation: BMC Nutr Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: London : BioMed Central, [2015]- |
مستخلص: | Background: Supplementation with large doses of antioxidants, such as vitamin C and E, has been shown to blunt some adaptations to endurance training. The effects of antioxidant supplementation on adaptations to strength training is sparsely studied. Herein we investigated the effects of vitamin C and E supplementation on acute stress responses to exercise and adaptation to traditional heavy load strength training. Methods: In a double blind placebo-controlled design, twenty-eight, young, trained males and females were randomly assigned to receive either vitamin C and E (C: 1000 mg, E: 235 mg, per day) or placebo supplements, and underwent strength training for 10 weeks. After five weeks, a subgroup conducted a strength training session to investigate acute stress responses. Muscle samples were obtained to investigate changes in stress responses and in proteins and mRNA related to the heat shock proteins (HSPs) or antioxidant enzymes. Results: The acute responses to the exercise session revealed activation of the NFκB pathway indicated by degradation of IκBα in both groups. Vitamin C and E supplementation had, however, no effects on the acute stress responses. Furthermore, ten weeks of strength training did not change muscle αB-crystallin, HSP27, HSP70, GPx1 or mnSOD levels, with no influence of supplementation. Conclusions: Our results showed that although vitamin C and E supplementation has been shown to interfere with training adaptations, it did not affect acute stress responses or long-term training adaptations in the HSPs or antioxidant enzymes in this study. Competing Interests: Competing interestsThe authors declare that they have no competing interests. (© The Author(s). 2017.) |
References: | Ann N Y Acad Sci. 2005 May;1042:255-61. (PMID: 15965070) Pflugers Arch. 2001 Jun;442(3):426-34. (PMID: 11484775) Physiol Rev. 2008 Oct;88(4):1243-76. (PMID: 18923182) Physiol Rep. 2014 Oct 07;2(10):. (PMID: 25293598) Exerc Immunol Rev. 2001;7:90-107. (PMID: 11579750) Scand J Med Sci Sports. 2016 Jul;26(7):755-63. (PMID: 26129928) J Physiol. 2014 Apr 15;592(8):1887-901. (PMID: 24492839) BMC Sports Sci Med Rehabil. 2014 Jul 05;6:28. (PMID: 25075311) Med Sci Sports Exerc. 2010 Jul;42(7):1388-95. (PMID: 20019626) J Physiol. 2014 Dec 15;592(24):5391-408. (PMID: 25384788) Appl Physiol Nutr Metab. 2012 Dec;37(6):1239-46. (PMID: 23176530) Acta Physiol (Oxf). 2014 Aug;211(4):634-46. (PMID: 24762334) J Appl Physiol (1985). 2006 May;100(5):1679-87. (PMID: 16384840) J Mol Med (Berl). 2008 Jul;86(7):747-59. (PMID: 18246321) Front Biosci. 2007 Sep 01;12:4826-38. (PMID: 17569613) Acta Physiol (Oxf). 2008 Nov;194(3):215-22. (PMID: 18489727) Mech Ageing Dev. 2006 Nov;127(11):830-9. (PMID: 16996110) J Physiol. 2013 Oct 15;591(20):5047-59. (PMID: 23878368) Proc Natl Acad Sci U S A. 2009 May 26;106(21):8665-70. (PMID: 19433800) Eur J Appl Physiol. 2012 May;112(5):1773-82. (PMID: 21901266) Sports Med. 2009;39(8):643-62. (PMID: 19769414) Med Sci Sports Exerc. 2011 Jul;43(7):1334-59. (PMID: 21694556) J Appl Physiol (1985). 2012 Mar;112(6):990-1000. (PMID: 22207723) Nucleic Acids Res. 2001 May 1;29(9):e45. (PMID: 11328886) DNA Cell Biol. 1994 Nov;13(11):1127-36. (PMID: 7702755) J Mol Biol. 2014 Jan 9;426(1):116-35. (PMID: 24041570) J Physiol. 2003 Jun 1;549(Pt 2):645-52. (PMID: 12692182) Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R844-53. (PMID: 17522120) Int J Sport Nutr. 1994 Dec;4(4):320-34. (PMID: 7874149) Eur J Appl Physiol. 2006 Oct;98(3):310-22. (PMID: 16924527) Exp Gerontol. 2010 Nov;45(11):882-95. (PMID: 20705127) Am J Physiol Regul Integr Comp Physiol. 2000 Nov;279(5):R1539-45. (PMID: 11049834) |
فهرسة مساهمة: | Keywords: Gene expression; Resistance training; Stress proteins |
تواريخ الأحداث: | Date Created: 20200311 Latest Revision: 20220413 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7050865 |
DOI: | 10.1186/s40795-017-0185-8 |
PMID: | 32153849 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2055-0928 |
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DOI: | 10.1186/s40795-017-0185-8 |