دورية أكاديمية
Alien limb syndrome: A Bayesian account of unwanted actions.
| العنوان: | Alien limb syndrome: A Bayesian account of unwanted actions. |
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| المؤلفون: | Wolpe N; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK. Electronic address: nw305@medschl.cam.ac.uk., Hezemans FH; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK. |
| المصدر: | Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2020 Jun; Vol. 127, pp. 29-41. Date of Electronic Publication: 2020 Feb 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Masson Country of Publication: Italy NLM ID: 0100725 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1973-8102 (Electronic) Linking ISSN: 00109452 NLM ISO Abbreviation: Cortex Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Milan : Masson Original Publication: Varese. |
| مواضيع طبية MeSH: | Alien Limb Phenomenon*, Bayes Theorem ; Brain ; Humans ; Movement |
| مستخلص: | An alien limb is a debilitating disorder of volitional control. The core feature of alien limb is the performance of simple or complex semi-purposeful movements which the patient reports to be unintentional or unwanted, or occasionally in opposition to their intentions. Theories of the mechanism of alien limb phenomena have emphasised the role of disinhibition in the brain, and exaggerated action 'affordances'. However, despite advances in cognitive neuroscience research and a large public and media interest, there has been no unifying computational and anatomical account of the cause of alien limb movements. Here, we extend Bayesian brain principles to propose that alien limb is a disorder of 'predictive processing' in hierarchical sensorimotor brain networks. Specifically, we suggest that alien limb results from predictions about action outcomes that are afforded unduly high precision. The principal mechanism for this abnormally high precision is an impairment in the relay of input from medial regions, predominantly the supplementary motor area (SMA), which modulate the precision of lateral brain regions encoding the predicted action outcomes. We discuss potential implications of this model for future research and treatment of alien limb. (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust; 103838 United Kingdom WT_ Wellcome Trust; MC_UU_00005/12 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Action affordance; Alien limb; Dual premotor; Predictive processing; Supplementary motor area |
| تواريخ الأحداث: | Date Created: 20200311 Date Completed: 20210621 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7212084 |
| DOI: | 10.1016/j.cortex.2020.02.002 |
| PMID: | 32155475 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1973-8102 |
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| DOI: | 10.1016/j.cortex.2020.02.002 |