دورية أكاديمية
Bone-targeted PAMAM nanoparticle to treat bone metastases of lung cancer.
| العنوان: | Bone-targeted PAMAM nanoparticle to treat bone metastases of lung cancer. |
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| المؤلفون: | Bai SB; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China., Cheng Y; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China., Liu DZ; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China., Ji QF; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China., Liu M; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China., Zhang BL; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China., Mei QB; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of The State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an, 710032, PR China., Zhou SY; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China.; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of The State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an, 710032, PR China. |
| المصدر: | Nanomedicine (London, England) [Nanomedicine (Lond)] 2020 Apr; Vol. 15 (9), pp. 833-849. Date of Electronic Publication: 2020 Mar 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 101278111 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-6963 (Electronic) Linking ISSN: 17435889 NLM ISO Abbreviation: Nanomedicine (Lond) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Future Medicine Ltd., c2006- |
| مواضيع طبية MeSH: | Antineoplastic Agents*/therapeutic use , Bone Neoplasms*/drug therapy , Bone Neoplasms*/secondary , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Nanoparticles*, Alendronate ; Animals ; Docetaxel ; Drug Delivery Systems ; Mice ; Polyamines |
| مستخلص: | Aim: To prepare pH-sensitive nanoparticle composed of alendronate (ALN) and poly(amidoamine) (PAMAM) to treat bone metastases of lung cancer. Methods: The solvent evaporation method was used to prepare docetaxel (DTX)-loaded ALN-PAMAM nanoparticles (DTX@ALN-PAMAM). Results: The in vitro results showed DTX@ALN-PAMAM significantly enhanced the anticancer activity of DTX and inhibited the formation of osteoclasts. DTX@ALN-PAMAM concentrated at bone metastasis site in mice, which resulted in the suppression of bone resorption, pain response and growth of bone metastases. Eventually, the therapeutic effect of DTX on bone metastases of lung cancer was obviously improved. Conclusion: ALN modified PAMAM nanoparticle could be an effective platform for the treatment of bone metastases of lung cancer. |
| فهرسة مساهمة: | Keywords: PAMAM; alendronate; bone metastasis; docetaxel; lung cancer |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Poly(amidoamine)) 0 (Polyamines) 15H5577CQD (Docetaxel) X1J18R4W8P (Alendronate) |
| تواريخ الأحداث: | Date Created: 20200313 Date Completed: 20210608 Latest Revision: 20210608 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2217/nnm-2020-0024 |
| PMID: | 32163008 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1748-6963 |
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| DOI: | 10.2217/nnm-2020-0024 |