دورية أكاديمية
أعرض في EDS

Immunological roles of intestinal mesenchymal cells.

التفاصيل البيبلوغرافية
العنوان: Immunological roles of intestinal mesenchymal cells.
المؤلفون: Thomson CA; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Nibbs RJ; Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, UK., McCoy KD; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Mowat AM; Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, UK.
المصدر: Immunology [Immunology] 2020 Aug; Vol. 160 (4), pp. 313-324. Date of Electronic Publication: 2020 Apr 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2567 (Electronic) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: Inflammation/*immunology , Inflammatory Bowel Diseases/*immunology , Intestinal Mucosa/*immunology , Intestines/*immunology , Mesenchymal Stem Cells/*immunology, Animals ; Homeostasis ; Humans ; Immune Tolerance ; Immunity
مستخلص: The intestine is continuously exposed to an enormous variety and quantity of antigens and innate immune stimuli derived from both pathogens and harmless materials, such as food and commensal bacteria. Accordingly, the intestinal immune system is uniquely adapted to ensure appropriate responses to the different kinds of challenge; maintaining tolerance to harmless antigens in the steady-state, whilst remaining poised to deal with potential pathogens. To accomplish this, leucocytes of the intestinal immune system have to adapt to a constantly changing environment and interact with many different non-leucocytic intestinal cell types, including epithelial and endothelial cells, neurons, and a heterogenous network of intestinal mesenchymal cells (iMC). These interactions are intricately involved in the generation of protective immunity, the elaboration of inflammatory responses, and the development of inflammatory conditions, such as inflammatory bowel diseases. Here we discuss recent insights into the immunological functions of iMC under homeostatic and inflammatory conditions, focusing particularly on iMC in the mucosa and submucosa, and highlighting how an appreciation of the immunology of iMC may help understand the pathogenesis and treatment of disease.
(© 2020 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 201903PJT-420305 Canada CIHR; JDRF 2-SRA-2018-547-S-B United States JDRF Juvenile Diabetes Research Foundation; United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: homeostasis; immune response; inflammation; intestine; mesenchymal stromal cell
تواريخ الأحداث: Date Created: 20200318 Date Completed: 20210526 Latest Revision: 20210802
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7370112
DOI: 10.1111/imm.13191
PMID: 32181492
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2567
DOI:10.1111/imm.13191