دورية أكاديمية
It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice.
| العنوان: | It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice. |
|---|---|
| المؤلفون: | Gundry MC; Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Goodell MA; Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA; Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Stem Cell and Regenerative Medicine, Baylor College of Medicine, Houston, TX, USA., Brunetti L; Department of Medicine, University of Perugia, Perugia, Italy. Electronic address: lorenzo.brunetti@unipg.it. |
| المصدر: | Cancer cell [Cancer Cell] 2020 Mar 16; Vol. 37 (3), pp. 267-269. |
| نوع المنشور: | Journal Article; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press, c2002- |
| مواضيع طبية MeSH: | Homeodomain Proteins/*genetics , Myeloid-Lymphoid Leukemia Protein/*genetics, Animals ; Chromatin ; Histone-Lysine N-Methyltransferase/genetics ; Mice ; Nuclear Proteins ; Nucleophosmin |
| مستخلص: | Several acute myeloid leukemia genetic sub-types converge on high expression of HOX genes, critical for their self-renewal. A new orally bioavailable Menin-MLL inhibitor (VTP-50469) appears to promote their differentiation through direct effects on the HOX cofactor MEIS1, paving the way for clinical trials. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment on: Cancer Cell. 2019 Dec 9;36(6):660-673.e11. (PMID: 31821784) |
| المشرفين على المادة: | 0 (Chromatin) 0 (Homeodomain Proteins) 0 (NPM1 protein, human) 0 (Npm1 protein, mouse) 0 (Nuclear Proteins) 117896-08-9 (Nucleophosmin) 149025-06-9 (Myeloid-Lymphoid Leukemia Protein) EC 2.1.1.43 (Histone-Lysine N-Methyltransferase) |
| تواريخ الأحداث: | Date Created: 20200319 Date Completed: 20200717 Latest Revision: 20211204 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ccell.2020.02.011 |
| PMID: | 32183947 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1878-3686 |
|---|---|
| DOI: | 10.1016/j.ccell.2020.02.011 |