دورية أكاديمية
أعرض في EDS

Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis.

التفاصيل البيبلوغرافية
العنوان: Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis.
المؤلفون: Poh TY; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Tiew PY; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore., Lim AYH; Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore., Thng KX; School of Biological Sciences, Nanyang Technological University, Singapore., Binte Mohamed Ali NA; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Narayana JK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Mac Aogáin M; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Tien Z; School of Biological Sciences, Nanyang Technological University, Singapore., Chew WM; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore., Wai Chan AK; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore., Keir HR; Ninewells Hospital and Medical School, University of Dundee, Scotland., Dicker AJ; Ninewells Hospital and Medical School, University of Dundee, Scotland., Hassan TM; Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia., Xu H; Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore., Tee AKH; Department of Respiratory and Critical Care Medicine, Changi General Hospital, Singapore., Ong TH; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore., Koh MS; Duke-NUS Medical School, Singapore; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore., Abisheganaden JA; Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore., Chalmers JD; Ninewells Hospital and Medical School, University of Dundee, Scotland., Chotirmall SH; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address: schotirmall@ntu.edu.sg.
المصدر: Chest [Chest] 2020 Aug; Vol. 158 (2), pp. 512-522. Date of Electronic Publication: 2020 Mar 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0231335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-3543 (Electronic) Linking ISSN: 00123692 NLM ISO Abbreviation: Chest Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : New York : Elsevier
Original Publication: Chicago : American College of Chest Physicians
مواضيع طبية MeSH: Asian People*, Bronchiectasis/*blood , Bronchiectasis/*ethnology , Hexosaminidases/*blood , Pulmonary Aspergillosis/*blood , Pulmonary Aspergillosis/*ethnology, Adult ; Aged ; Aspergillus ; Asthma/blood ; Asthma/complications ; Asthma/ethnology ; Bronchiectasis/complications ; Female ; Humans ; Malaysia ; Male ; Middle Aged ; Prospective Studies ; Pulmonary Aspergillosis/complications ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/ethnology ; Scotland ; Singapore
مستخلص: Background: Chitinase activity is an important innate immune defence mechanism against infection that includes fungi. The 2 human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase are associated to allergy, asthma, and COPD; however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO) is unknown.
Research Question: What is the association between chitinase activity, airway fungi and clinical outcomes in bronchiectasis and bronchiectasis-COPD overlap?
Study Design and Methods: A prospective cohort of 463 individuals were recruited across five hospital sites in three countries (Singapore, Malaysia, and Scotland) including individuals who were not diseased (n = 35) and who had severe asthma (n = 54), COPD (n = 90), bronchiectasis (n = 241) and BCO (n = 43). Systemic chitinase levels were assessed for bronchiectasis and BCO and related to clinical outcomes, airway Aspergillus status, and underlying pulmonary mycobiome profiles.
Results: Systemic chitinase activity is elevated significantly in bronchiectasis and BCO and exceed the activity in other airway diseases. CHIT1 activity strongly predicts bronchiectasis exacerbations and is associated with the presence of at least one Aspergillus species in the airway and frequent exacerbations (≥3 exacerbations/y). Subgroup analysis reveals an association between CHIT1 activity and the "frequent exacerbator" phenotype in South-East Asian patients whose airway mycobiome profiles indicate the presence of novel fungal taxa that include Macroventuria, Curvularia and Sarocladium. These taxa, enriched in frequently exacerbating South-East Asian patients with high CHIT1 may have potential roles in bronchiectasis exacerbations.
Interpretation: Systemic CHIT1 activity may represent a useful clinical tool for the identification of fungal-driven "frequent exacerbators" with bronchiectasis in South-East Asian populations.
(Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: acid mammalian chitinase; bronchiectasis; chitinase; chitotriosidase; exacerbation
المشرفين على المادة: EC 3.2.1.- (Hexosaminidases)
EC 3.2.1.- (chitotriosidase)
تواريخ الأحداث: Date Created: 20200319 Date Completed: 20210524 Latest Revision: 20221207
رمز التحديث: 20240628
DOI: 10.1016/j.chest.2020.02.048
PMID: 32184111
قاعدة البيانات: MEDLINE
الوصف
تدمد:1931-3543
DOI:10.1016/j.chest.2020.02.048