تقرير
Iron overload and periodontal status in patients with sickle cell anaemia: A case series.
العنوان: | Iron overload and periodontal status in patients with sickle cell anaemia: A case series. |
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المؤلفون: | Costa SA; Postgraduate Dentistry Program, Federal University of Maranhão, São Luís, Brazil., Moreira ARO; Dentistry, Federal University of Maranhão, São Luís, Brazil., Costa CPS; Dentistry, Federal University of Maranhão, São Luís, Brazil., Carvalho Souza SF; Department of Dentistry, Federal University of Maranhão, São Luís, Brazil. |
المصدر: | Journal of clinical periodontology [J Clin Periodontol] 2020 Jun; Vol. 47 (6), pp. 668-675. Date of Electronic Publication: 2020 Apr 20. |
نوع المنشور: | Case Reports; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0425123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-051X (Electronic) Linking ISSN: 03036979 NLM ISO Abbreviation: J Clin Periodontol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Malden, MA : Wiley-Blackwell Original Publication: Copenhagen, Munksgaard. |
مواضيع طبية MeSH: | Anemia, Sickle Cell*/complications , Iron Overload* , Periodontitis*/complications , Periodontitis*/epidemiology, Humans ; Periodontal Attachment Loss ; Periodontal Index |
مستخلص: | Aim: To investigate the association among iron overload, periodontal status, and periodontitis progression rate in sickle cell anaemia (SCA). Materials and Methods: This case series evaluated 123 patients. Clinical attachment level (CAL) and probing depth (PD) were evaluated at six sites per tooth. Alveolar bone loss was estimated using periapical radiography. Study outcomes were periodontal status (measured as number of sites with CAL of ≥3 mm, CAL of ≥5 mm, PD of ≥4 mm, and PD of ≥6 mm) and periodontitis progression rate (determined as ratio of alveolar bone loss to age). Serum transferrin saturation and ferritin levels were obtained from medical records. Poisson regression was performed to estimate associations. Covariables included in the adjusted models (comorbidities, skin colour, socioeconomic class, and vaso-occlusive crisis) were defined by DAGs. Results: Serum transferrin saturation level revealed a significant positive association with the number of sites with CAL of ≥3 mm, CAL of ≥5 mm, PD of ≥4 mm, and PD of ≥6 mm. Patients with serum transferrin saturation level of >45% were 1.93 times more likely to have rapid periodontitis progression. Conclusion: High serum transferrin saturation level is associated with a greater extent of periodontitis and rapid periodontitis progression in SCA. (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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فهرسة مساهمة: | Keywords: ferritins; iron overload; periodontal disease; sickle cell anaemia; transferrin |
تواريخ الأحداث: | Date Created: 20200320 Date Completed: 20210128 Latest Revision: 20210128 |
رمز التحديث: | 20240628 |
DOI: | 10.1111/jcpe.13284 |
PMID: | 32189376 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1600-051X |
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DOI: | 10.1111/jcpe.13284 |