دورية أكاديمية
Liver Fibrosis in Rheumatoid Arthritis Patients Treated with Methotrexate.
| العنوان: | Liver Fibrosis in Rheumatoid Arthritis Patients Treated with Methotrexate. |
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| المؤلفون: | Hilal G; Department of Rheumatology, CHU Hassan II, Fez, Morocco., Akasbi N; Department of Rheumatology, CHU Hassan II, Fez, Morocco., Boudouaya H; Department of Epidemiology, CHU Hassan II, Fez, Morocco., Salma K; Department of Rheumatology, CHU Hassan II, Fez, Morocco., Harzy T; Department of Rheumatology, CHU Hassan II, Fez, Morocco. |
| المصدر: | Current rheumatology reviews [Curr Rheumatol Rev] 2020; Vol. 16 (4), pp. 293-297. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101261938 Publication Model: Print Cited Medium: Internet ISSN: 1875-6360 (Electronic) Linking ISSN: 15733971 NLM ISO Abbreviation: Curr Rheumatol Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, 2005- |
| مواضيع طبية MeSH: | Antirheumatic Agents/*administration & dosage , Arthritis, Rheumatoid/*drug therapy , Arthritis, Rheumatoid/*epidemiology , Liver Cirrhosis/*diagnosis , Liver Cirrhosis/*epidemiology , Methotrexate/*administration & dosage, Adult ; Aged ; Antirheumatic Agents/adverse effects ; Cross-Sectional Studies ; Female ; Humans ; Liver Cirrhosis/chemically induced ; Male ; Methotrexate/adverse effects ; Middle Aged ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Introduction: Methotrexate (MTX) is a highly effective therapy for patients with rheumatoid arthritis (RA). However, it has been associated with a range of liver related adverse events. The aim of our study was to evaluate the prevalence rate of liver fibrosis in RA patients and to assess the correlation of cumulative MTX dose with hepatic fibrosis in our context. Materials and Methods: This is a cross-sectional study, whose goal is to describe and analyze the factors correlated with the liver fibrosis in RA patients treated with methotrexate especially the cumulative dose of MTX, along the period lying between January 2012 and March 2019. The study was carried out in the Rheumatology Department of the University Hospital Hassan II of Fez. The patients have met the assessment of the ACR 2010 criteria. The data was recorded and analyzed using SPSS v20 univariate and bivariate analysis. A value of p <0.05 has been used to identify factors associated with liver fibrosis. Results: A total of 319 patients with RA were recruited who were on MTX treatment. There were 276 female and 43 male patients (female: male ratio of 6.3). The average age was 53 years + /-12.4 years. The average duration of symptoms was 10.68 +/-6.9 years. RA was seropositive for the rheumatoid factor or the anti-ccp in 90.3 %. Six patients (2%) had developed liver fibrosis while on MTX therapy. In the bivariate analysis, the liver fibrosis is significantly related to the hepatic cytolysis (p<0.001) and to the combination of MTX with other DMARDs (p<0.05). However, the multiple logistic regression analysis did not find any significant association between the groups. Conclusion: In our context, the prevalence rate of hepatic fibrosis in patients with rheumatoid arthritis under methotrexate is low. It is seen much more in patients treated with methotrexate in combination with other disease-modifying anti-rheumatic drugs (DMARDs). These results require confirmation in a larger number of patients. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: DMARDs; Methotrexate; anti-TNF therapy; hepatic fibrosis; liver fibrosis; rheumatoid arthritis |
| المشرفين على المادة: | 0 (Antirheumatic Agents) YL5FZ2Y5U1 (Methotrexate) |
| تواريخ الأحداث: | Date Created: 20200320 Date Completed: 20211006 Latest Revision: 20211006 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1573397116666200319155247 |
| PMID: | 32189595 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-6360 |
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| DOI: | 10.2174/1573397116666200319155247 |