دورية أكاديمية
أعرض في EDS

Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study.

التفاصيل البيبلوغرافية
العنوان: Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study.
المؤلفون: Tsai TJ; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.; National Yang-Ming University, Taipei, Taiwan., Chen WC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.; National Yang-Ming University, Taipei, Taiwan., Huang YT; Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, Taiyuan, Taiwan., Yang YH; Center for Medical Informatics and Statistics, Kaohsiung Medical University, Kaohsiung, Taiwan., Feng IC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan., Wu WC; Division of GERD Center, Yuan Sheng Hospital, Changhua, Taiwan., Hu HM; Division of Gastroenterology & Hepatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Wu DC; Division of Gastroenterology & Hepatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan., Hsu PI; Department of Medicine, An Nan Hospital, China Medical University, Taiwan.
المصدر: Gastroenterology research and practice [Gastroenterol Res Pract] 2020 Mar 03; Vol. 2020, pp. 7206171. Date of Electronic Publication: 2020 Mar 03 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101475557 Publication Model: eCollection Cited Medium: Print ISSN: 1687-6121 (Print) Linking ISSN: 16876121 NLM ISO Abbreviation: Gastroenterol Res Pract Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cairo : Hindawi Publishing Corporation
مستخلص: Background: Patients with chronic kidney disease (CKD) with or without hemodialysis were considered to have bleeding tendency and higher risk for gastrointestinal (GI) bleeding. Previous studies had documented that hemodialysis may increase the gastroduodenal ulcer bleeding. Few studies evaluated the relationship between CKD and lower GI bleeding. Materials and Methods . An observational cohort study design was conducted. The end-stage renal disease (ESRD) patients receiving regular hemodialysis (dialysis CKD), CKD patients without dialysis (dialysis-free CKD), and controls were selected from 1 million randomly sampled subjects in the National Health Insurance Research Database of Taiwan. These three group subjects were matched by age, sex, comorbidity, and enrollment time in a 1 : 2 : 2 ratio. The Cox proportional hazard regression models were used to identify the potential risk factors for lower gastrointestinal bleeding.
Results: Dialysis CKD patients ( n = 574) had a higher incidence of lower GI bleeding than dialysis-free CKD patients ( n = 574) had a higher incidence of lower GI bleeding than dialysis-free CKD patients ( n = 574) had a higher incidence of lower GI bleeding than dialysis-free CKD patients ( P < 0.001). Multivariate analysis showed that extreme old age (age ≥ 85), male gender, dialysis-free CKD, and dialysis CKD were independent factors of lower GI bleeding. Additionally, dialysis CKD patients also had a higher incidence of angiodysplasia bleeding compared to dialysis-free CKD patients and control subjects (1.1% vs. 0.1% and 0.1%, respectively; both P < 0.001). Multivariate analysis showed that extreme old age (age ≥ 85), male gender, dialysis-free CKD, and dialysis CKD were independent factors of lower GI bleeding. Additionally, dialysis CKD patients also had a higher incidence of angiodysplasia bleeding compared to dialysis-free CKD patients and control subjects (1.1% vs. 0.1% and 0.1%, respectively; both.
Conclusion: Hemodialysis may have higher risk of lower GI bleeding and angiodysplasia bleeding.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2020 Tzung-Jiun Tsai et al.)
References: CMAJ. 2011 Dec 13;183(18):E1345-51. (PMID: 22083684)
Can J Kidney Health Dis. 2014 Sep 02;1:21. (PMID: 25780611)
BMC Nephrol. 2013 Jan 16;14:15. (PMID: 23324652)
Clin J Am Soc Nephrol. 2014 Aug 7;9(8):1354-9. (PMID: 24903385)
Langenbecks Arch Surg. 2001 Feb;386(1):8-16. (PMID: 11405093)
Nephrol Dial Transplant. 2005 Dec;20(12):2587-93. (PMID: 16204281)
Am J Gastroenterol. 1996 Nov;91(11):2329-32. (PMID: 8931412)
Aliment Pharmacol Ther. 2017 Jun;45(12):1542-1550. (PMID: 28449186)
Am J Med Sci. 1998 Aug;316(2):94-104. (PMID: 9704663)
Aliment Pharmacol Ther. 2014 Jan;39(1):15-34. (PMID: 24138285)
Am J Kidney Dis. 2007 Jan;49(1):46-55. (PMID: 17185145)
Am J Kidney Dis. 2007 May;49(5):626-33. (PMID: 17472844)
Lancet. 2008 Jun 28;371(9631):2173-82. (PMID: 18586172)
Am J Gastroenterol. 1993 Jun;88(6):807-18. (PMID: 8389094)
J Gastroenterol Hepatol. 2018 Jun;33(6):1185-1191. (PMID: 29156506)
Clin J Am Soc Nephrol. 2015 Mar 6;10(3):353-62. (PMID: 25527706)
Gastrointest Endosc. 2014 Dec;80(6):1124-31. (PMID: 25088922)
Arch Intern Med. 2000 Jul 24;160(14):2093-9. (PMID: 10904451)
Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):194-201. (PMID: 21118353)
Clin Gastroenterol Hepatol. 2015 May;13(5):906-12.e2. (PMID: 25460554)
World J Gastroenterol. 2017 Dec 21;23(47):8415-8425. (PMID: 29308001)
Gastrointest Endosc. 2010 Jan;71(1):44-9. (PMID: 19595311)
Semin Thromb Hemost. 2004 Oct;30(5):579-89. (PMID: 15497100)
Nephrology (Carlton). 2010 Jun;15 Suppl 2:3-9. (PMID: 20586940)
Gut. 2011 Aug;60(8):1038-42. (PMID: 21266725)
Am J Kidney Dis. 2018 Mar;71(3 Suppl 1):A7. (PMID: 29477157)
Am J Gastroenterol. 2009 Jul;104(7):1633-41. (PMID: 19574968)
Dig Dis Sci. 2014 Apr;59(4):807-13. (PMID: 24318806)
Saudi J Kidney Dis Transpl. 2008 Sep;19(5):809-12. (PMID: 18711303)
Nephron. 2018;140(3):175-184. (PMID: 30138926)
Kidney Int. 2003 Oct;64(4):1455-61. (PMID: 12969166)
Clin J Am Soc Nephrol. 2016 Oct 7;11(10):1735-1743. (PMID: 27515592)
Am J Kidney Dis. 2006 Nov;48(5):727-38. (PMID: 17059992)
Am J Nephrol. 2012;35(3):216-24. (PMID: 22310659)
تواريخ الأحداث: Date Created: 20200320 Latest Revision: 20220413
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7072111
DOI: 10.1155/2020/7206171
PMID: 32190042
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-6121
DOI:10.1155/2020/7206171