دورية أكاديمية
Association of particles of lipoprotein subclasses with arterial stiffness in a high-risk working population: the Baptist Employee Healthy Heart Study (BEHHS).
العنوان: | Association of particles of lipoprotein subclasses with arterial stiffness in a high-risk working population: the Baptist Employee Healthy Heart Study (BEHHS). |
---|---|
المؤلفون: | Aziz M; Family Medicine Center, West Kendall Baptist Hospital, Miami, FL, USA.; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, 9555 SW 162nd Ave. MAB, Suite 103, Miami, FL, 33196, USA.; Florida International University, Department of Humanities, Health, and Society (HHS), Herbert Wertheim College of Medicine, Miami, FL, USA., Gannarapu S; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, 9555 SW 162nd Ave. MAB, Suite 103, Miami, FL, 33196, USA., Humayun C; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, 9555 SW 162nd Ave. MAB, Suite 103, Miami, FL, 33196, USA., Siddiqui U; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, 9555 SW 162nd Ave. MAB, Suite 103, Miami, FL, 33196, USA., Nasir K; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, 9555 SW 162nd Ave. MAB, Suite 103, Miami, FL, 33196, USA.; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT, 06510, USA.; Johns Hopkins University, Johns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, MD, USA., Aneni EC; Center for Healthcare Advancement & Outcomes, Baptist Health South Florida, 9555 SW 162nd Ave. MAB, Suite 103, Miami, FL, 33196, USA. ehianeni@outlook.com.; Internal Medicine, Section of Cardiovascular Medicine, Yale-New Haven Hospital, New Haven, CT, 06510, USA. ehianeni@outlook.com. |
المصدر: | The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology [Egypt Heart J] 2020 Mar 19; Vol. 72 (1), pp. 12. Date of Electronic Publication: 2020 Mar 19. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 9106952 Publication Model: Electronic Cited Medium: Internet ISSN: 2090-911X (Electronic) Linking ISSN: 11102608 NLM ISO Abbreviation: Egypt Heart J Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2019- : Berlin : Springer Original Publication: Cairo, Egypt : The Society, [1988- |
مستخلص: | Background: Arterial stiffness is an independent predictor of cardiovascular disease (CVD) morbidity and mortality. A risk factor-independent association of arterial stiffness with traditional lipids has been described extensively, but it is still unclear whether an independent relationship exists between arterial stiffness and particles of lipoprotein subclasses. Methods: The Baptist Employee Healthy Heart Study (BEHHS) is a lifestyle intervention study examining the effects of web-based programs on reducing CVD risk in high-risk persons. Participants had their brachial arterial augmentation index (AI, a measure arterial stiffness) assessed using the EndoPAT 2000 device. Cardio IQ™ ion mobility lipoprotein fractionation was utilized for measurement of particles of lipoprotein subclasses. Results: The population consisted of 182 participants, (74% women, 49% Hispanic) with a mean age of 52 ± 9 years. There was a significant trend association between quartiles of AI and total cholesterol, HDL-c, large LDL-p, small IDL-p, large IDL-p, and all subclasses of HDL particles (total HDL-p, small HDL-p, and large HDL-p). In logistic regression analysis, only HDL-c, total LDL-p, large LDL-p, small IDL-p, large IDL-p, total HDL-p, small HDL-p, and large HDL-p demonstrated significant independent association with AI. Conclusion: Several lipoprotein subclasses demonstrate independent significant associations with arterial stiffness. A safe and relatively inexpensive blood test may be useful in identifying subclinical atherosclerosis process in a relatively young high CVD risk population. Trial Registration: ClinicalTrials.gov, NCT01912209. Registered July 31, 2013. |
References: | Hypertension. 2009 Nov;54(5):1099-105. (PMID: 19720955) J Atheroscler Thromb. 2010 Dec 26;17(12):1282-9. (PMID: 20834193) Am J Hypertens. 2005 Feb;18(2 Pt 1):249-60. (PMID: 15752954) J Pediatr Endocrinol Metab. 2010 Jul;23(7):661-7. (PMID: 20857838) Clin Chem. 2008 Aug;54(8):1307-16. (PMID: 18515257) Medicine (Baltimore). 2016 Dec;95(51):e5368. (PMID: 28002323) Clin Chem. 2011 Aug;57(8):1178-87. (PMID: 21700954) Circulation. 2004 Jan 20;109(2):184-9. (PMID: 14662706) Age Ageing. 2007 Jan;36(1):43-8. (PMID: 17114200) Vasc Health Risk Manag. 2005;1(3):183-98. (PMID: 17319104) Arterioscler Thromb Vasc Biol. 1998 Jul;18(7):1046-53. (PMID: 9672064) Hypertension. 2001 May;37(5):1236-41. (PMID: 11358934) Metabolism. 2005 Feb;54(2):264-70. (PMID: 15690322) Nutr Metab Cardiovasc Dis. 2009 May;19(4):241-6. (PMID: 18815016) Vasc Med. 2012 Feb;17(1):29-36. (PMID: 22363016) Trials. 2016 Jul 01;17(1):308. (PMID: 27369488) Hypertension. 2008 Jan;51(1):112-8. (PMID: 17998476) Diabetes Care. 2009 Nov;32 Suppl 2:S314-21. (PMID: 19875572) Clin Exp Pharmacol Physiol. 2007 Oct;34(10):1005-9. (PMID: 17714086) J Hum Hypertens. 2014 Feb;28(2):111-7. (PMID: 23823580) Atherosclerosis. 2007 May;192(1):211-7. (PMID: 16765964) Clin Physiol Funct Imaging. 2010 Sep;30(5):313-7. (PMID: 20545714) Clin Lab Med. 2006 Dec;26(4):847-70. (PMID: 17110242) Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1975-80. (PMID: 19729614) Lipids Health Dis. 2014 Feb 20;13:37. (PMID: 24555711) Diab Vasc Dis Res. 2014 May;11(3):201-7. (PMID: 24659234) |
فهرسة مساهمة: | Keywords: Arterial stiffness; Augmentation index; Employee population; Lipoprotein; Lipoprotein subclasses |
سلسلة جزيئية: | ClinicalTrials.gov NCT01912209 |
تواريخ الأحداث: | Date Created: 20200321 Latest Revision: 20200928 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC7082444 |
DOI: | 10.1186/s43044-020-00046-4 |
PMID: | 32193785 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2090-911X |
---|---|
DOI: | 10.1186/s43044-020-00046-4 |