دورية أكاديمية
A double-blind placebo-controlled randomized trial on the effect of hyosine n-butyl bromide for improving duration of labor in term pregnancies.
| العنوان: | A double-blind placebo-controlled randomized trial on the effect of hyosine n-butyl bromide for improving duration of labor in term pregnancies. |
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| المؤلفون: | Ejikeme TB; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Eleje GU; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.; Effective Care Research Unit, Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria., Igberase GO; Department of Obstetrics and Gynaecology, Delta State University, Abraka, Nigeria., Ugwu EO; Department of Obstetrics and Gynaecology, University of Nigeria Enugu Campus, Enugu, Nigeria., Ikwuka DC; Department of Human Physiology, University of Nigeria, Nsukka, Nigeria., Okpala BC; Department of Obstetrics and Gynecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.; Effective Care Research Unit, Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria. |
| المصدر: | The journal of obstetrics and gynaecology research [J Obstet Gynaecol Res] 2020 Jun; Vol. 46 (6), pp. 890-898. Date of Electronic Publication: 2020 Mar 20. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley on behalf of the Japan Society of Obstetrics and Gynecology] Country of Publication: Australia NLM ID: 9612761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1447-0756 (Electronic) Linking ISSN: 13418076 NLM ISO Abbreviation: J Obstet Gynaecol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [Melbourne, Vic. : Wiley on behalf of the Japan Society of Obstetrics and Gynecology] Original Publication: Tokyo : University of Tokyo Press, c1996- |
| مواضيع طبية MeSH: | Hydrocarbons, Brominated/*administration & dosage , Labor Stage, First/*drug effects , Labor Stage, Second/*drug effects , Scopolamine/*administration & dosage, Adult ; Double-Blind Method ; Dystocia/drug therapy ; Female ; Humans ; Hydrocarbons, Brominated/pharmacology ; Injections ; Nigeria ; Pregnancy ; Scopolamine/pharmacology ; Time Factors |
| مستخلص: | Aim: To compare the effectiveness of intramuscular hyocine n-butyl bromide (HBB) with placebo for shortening the duration of the first stage of labor in term pregnancies. Methods: A double blind placebo-controlled randomized trial of parturients who presented at term in the active phase of labor was conducted. They were randomly (1:1 ratio) given intramuscular injection of either 40 mg (2 mL) of HBB or 2 mL of water for injection as a placebo. The primary outcome measures were the duration of first and second stages of labor. Subgroup analysis of primigravid and multigravid women were also performed for various outcomes. We did intention-to-treat analysis. Results: Sixty-two women were randomized to each group and none were lost to follow-up. Baseline characteristics were similar between the HBB and placebo groups. The mean duration of first stage of labor was noted to be significantly shorter in the HBB group for both the primigravidas (246.6 ± 21.9 vs 391.8 ± 56.6 min for control; P < 0.001) and for multigravidas (205.9 ± 17.8 vs 323.8 ± 16.0 min for control;P < 0.001).There was also significantly shorter duration of second stage of labor in the HBB group (primigravida: P = 0.013; multigravida: P = 0.016). The duration of third stage of labor, mode of delivery and maternal and/or neonatal outcomes for both classes of parturients were not significantly different. Conclusion: HBB is effective in reducing the first and second stages of labor without adverse maternal or neonatal outcome. HBB does not significantly influence the duration of third stage of labor including mode of delivery. More evidence is needed to further explore the potential useful role of HBB in the active phase of labor. (© 2020 Japan Society of Obstetrics and Gynecology.) |
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| فهرسة مساهمة: | Keywords: hyocine n-butyl bromide; labor; parturients; prolonged |
| المشرفين على المادة: | 0 (Hydrocarbons, Brominated) DL48G20X8X (Scopolamine) SAV6Y78U3D (butyl bromide) |
| تواريخ الأحداث: | Date Created: 20200321 Date Completed: 20210301 Latest Revision: 20210301 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/jog.14251 |
| PMID: | 32196856 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1447-0756 |
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| DOI: | 10.1111/jog.14251 |