دورية أكاديمية
أعرض في EDS

Polyacrylamide-Metilcellulose Hydrogels Containing Aloe barbadensis Extract as Dressing for Treatment of Chronic Cutaneous Skin Lesions.

التفاصيل البيبلوغرافية
العنوان: Polyacrylamide-Metilcellulose Hydrogels Containing Aloe barbadensis Extract as Dressing for Treatment of Chronic Cutaneous Skin Lesions.
المؤلفون: Alesa Gyles D; Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Pereira Júnior AD; Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Diniz Castro L; Laboratory of Pharmaceutical and Cosmetic R&D, College of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Santa Brigida A; Laboratory of Chromatography and Mass Spectrometry, Faculty of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Nobre Lamarão ML; Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Ramos Barbosa WL; Laboratory of Chromatography and Mass Spectrometry, Faculty of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Carréra Silva Júnior JO; Laboratory of Pharmaceutical and Cosmetic R&D, College of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Ribeiro-Costa RM; Laboratory of Pharmaceutical Nanotechnology, College of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil.
المصدر: Polymers [Polymers (Basel)] 2020 Mar 19; Vol. 12 (3). Date of Electronic Publication: 2020 Mar 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101545357 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4360 (Electronic) Linking ISSN: 20734360 NLM ISO Abbreviation: Polymers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مستخلص: Chronic wounds are severe breaks in the skin barrier that fail to heal in an acceptable time-frame, thus preventing the complete restoration of the tissue's anatomical and functional integrity, increasing the likelihood of infections and apoptosis. Hydrogels are known as a drug delivery system and have the potential to cover wounds and burns on the skin. Aloe barbadensis contains over 75 different bioactive compounds which are responsible for its anti-inflammatory and antimicrobial properties. In this study, the polyacrylamide-co-methylcellulose hydrogel containing Aloe barbadensis were developed. The extract was prepared from lyophilized Aloe barbadensis , using methanolic extraction, characterized by high performance liquid chromatography and incorporated into the hydrogels. These Aloe barbadensis hydrogels were characterized by degree of swelling, Fourier-transform infrared spectroscopy, scanning electron microscopy, and thermal profiling using thermogravimetric analysis. The minimum inhibitory concentration test was done on the Aloe barbadensis extract to evaluate its antibacterial and antifungal activity in vitro. The Aloe barbadensis hydrogels and were shown to swell to almost 2000% of their original sizes. The Fourier-transform infrared spectroscopy indicated the presence of bands characteristic of Aloe barbadensis and hydrogel polymers. The basic hydrogel showed greater thermal stability than the hydrogels with Aloe barbadensis . The minimum inhibitory concentration showed inhibition of the growth of S. aureus and Salmonella spp. at specific concentrations. The hydrogel therefore presents itself as an excellent potential curative cover of cutaneous lesions.
References: Sci Transl Med. 2014 Dec 3;6(265):265sr6. (PMID: 25473038)
Wound Repair Regen. 2009 Nov-Dec;17(6):763-71. (PMID: 19903300)
J Biomed Nanotechnol. 2012 Dec;8(6):891-900. (PMID: 23029997)
Molecules. 2019 Apr 19;24(8):. (PMID: 31010204)
Mem Inst Oswaldo Cruz. 2002 Oct;97(7):1027-31. (PMID: 12471432)
Iran J Med Sci. 2016 May;41(3 Suppl):S3. (PMID: 27840469)
Appl Biochem Biotechnol. 2010 Mar;160(5):1356-61. (PMID: 19263248)
J Chromatogr Sci. 2017 Mar 1;55(3):251-257. (PMID: 27884872)
Biomolecules. 2019 Dec 30;10(1):. (PMID: 31905975)
Biomed Res Int. 2015;2015:714216. (PMID: 26090436)
J Wound Care. 2019 Oct 2;28(10):683-693. (PMID: 31600106)
J Am Col Certif Wound Spec. 2009 May 23;1(2):49-50. (PMID: 24527113)
Clin Microbiol Rev. 2015 Jul;28(3):603-61. (PMID: 26016486)
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2006 Apr;24(1):103-54. (PMID: 16690538)
PLoS One. 2013;8(2):e56846. (PMID: 23451098)
Eplasty. 2009 Jun 04;9:e19. (PMID: 19578487)
Healthc Q. 2014;17(1):7-10. (PMID: 24844713)
J Clin Microbiol. 2013 Jul;51(7):2385-7. (PMID: 23596246)
J Eur Acad Dermatol Venereol. 2003 Sep;17(5):575-7. (PMID: 12941099)
Australas Med J. 2012;5(6):305-9. (PMID: 22848328)
J Pharm Anal. 2016 Apr;6(2):71-79. (PMID: 29403965)
Dermatology. 2013;226(2):172-84. (PMID: 23711429)
Saudi Pharm J. 2020 Jan;28(1):95-100. (PMID: 31920435)
Molecules. 2008 Aug 08;13(8):1599-616. (PMID: 18794775)
Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12601-6. (PMID: 23858432)
Skin Res Technol. 2006 Nov;12(4):241-6. (PMID: 17026654)
Int J Biol Macromol. 2020 Mar 15;147:314-318. (PMID: 31926229)
ACS Appl Mater Interfaces. 2012 May;4(5):2618-29. (PMID: 22489770)
Nurs Times. 2008 Jan 22-28;104(3):44-5. (PMID: 18293879)
Indian J Dermatol. 2008;53(4):163-6. (PMID: 19882025)
Sci Rep. 2015 Apr 15;5:9598. (PMID: 25873245)
Biomaterials. 2009 May;30(14):2826-36. (PMID: 19203791)
Am J Surg. 2004 May;187(5A):38S-43S. (PMID: 15147991)
معلومات مُعتمدة: 0 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 0 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: Aloe barbadensis; hydrogel; methylcellulose; phytotherapy; polyacrylamide; skin lesions
تواريخ الأحداث: Date Created: 20200325 Latest Revision: 20200928
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7183280
DOI: 10.3390/polym12030690
PMID: 32204517
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4360
DOI:10.3390/polym12030690