دورية أكاديمية
أعرض في EDS

Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia.

التفاصيل البيبلوغرافية
العنوان: Differences in expression of Peroxisome Proliferator-activated Receptor-γ in early-onset preeclampsia and late-onset preeclampsia.
المؤلفون: Permadi W; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Jl. Pasteur No. 38, Bandung, 40161, West Java, Indonesia., Mantilidewi KI; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Jl. Pasteur No. 38, Bandung, 40161, West Java, Indonesia. kmantilidewi@gmail.com., Khairani AF; Division of Cell Biology, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.; Oncology and Stem Cell Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia., Lantika UA; Department of Histology and Medical Biology, Faculty of Medicine, Bandung Islamic University, Jl. Tamansari No.22, Bandung, 40116, West Java, Indonesia., Ronosulistyo AR; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Jl. Pasteur No. 38, Bandung, 40161, West Java, Indonesia., Bayuaji H; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin Hospital, Jl. Pasteur No. 38, Bandung, 40161, West Java, Indonesia.
المصدر: BMC research notes [BMC Res Notes] 2020 Mar 27; Vol. 13 (1), pp. 181. Date of Electronic Publication: 2020 Mar 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Biomed Central, 2008.
مواضيع طبية MeSH: PPAR gamma/*blood , Pre-Eclampsia/*blood, Age of Onset ; Female ; Humans ; Pregnancy ; Trophoblasts/metabolism
مستخلص: Objective: PPARγ is a ligand-binding transcription factor that has been reported to be implicated in lipid metabolism, immune function, and cellular growth and differentiation. It has been suspected to play a role in the pathophysiology of preeclampsia, although the mechanism is yet to be elaborated. This study aims to investigate the expression of PPARγ in early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normal pregnancy. We conducted this study using primary trophoblastic cell culture incubated with serum from EOPE, LOPE, and normal pregnancy. The expression of PPARγ in these cells was analyzed using Western Blot. Statistical analysis was performed using one-way ANOVA and Bonferroni's post hoc test. p < 0.05 is considered significant.
Results: Serum from normal pregnant women and EOPE did not induce any difference in the expression of PPAR-γ (p > 0.05). In contrast, expression of PPAR-γ was increased in those cells induced by serum from LOPE (p < 0.001). Therefore, we conclude that hypothetically PPAR-γ might play role in the pathophysiology of LOPE but not in EOPE. Other possibility is the activity of PPAR-γ in EOPE is inversely correlated with its expression, therefore the high enzymatic activity of PPAR-γ is tightly regulated by attenuating its expression.
References: Microcirculation. 2014 Jan;21(1):4-14. (PMID: 23890192)
Hypertension. 2007 Apr;49(4):818-24. (PMID: 17261644)
Am J Obstet Gynecol. 1989 Nov;161(5):1200-4. (PMID: 2589440)
Control Clin Trials. 1996 Oct;17(5):442-69. (PMID: 8932976)
Placenta. 2009 Jun;30(6):473-82. (PMID: 19375795)
Cell. 2005 Dec 16;123(6):993-9. (PMID: 16360030)
PLoS One. 2020 Mar 3;15(3):e0230000. (PMID: 32126118)
Am J Obstet Gynecol. 2009 Jan;200(1):66.e1-6. (PMID: 18799154)
Reprod Biol Endocrinol. 2015 Jul 09;13:71. (PMID: 26156160)
Lancet. 2010 Aug 21;376(9741):631-44. (PMID: 20598363)
J Matern Fetal Neonatal Med. 2003 Jan;13(1):39-44. (PMID: 12710855)
Hypertension. 2005 Dec;46(6):1243-9. (PMID: 16230510)
J Perinat Med. 2011 Nov;39(6):641-52. (PMID: 21848483)
Placenta. 2009 Dec;30(12):1016-22. (PMID: 19846218)
Anal Biochem. 2012 Aug 15;427(2):187-9. (PMID: 22613053)
PPAR Res. 2014;2014:637251. (PMID: 24711815)
Placenta. 2010 Mar;31(3):222-9. (PMID: 20045185)
J Obstet Gynaecol Res. 2013 Mar;39(3):627-31. (PMID: 23107382)
Biochem Pharmacol. 2015 Jun 15;95(4):211-26. (PMID: 25916268)
Placenta. 2000 May;21(4):436-40. (PMID: 10833383)
Placenta. 2011 Feb;32 Suppl:S49-54. (PMID: 21257083)
PLoS One. 2009 Nov 30;4(11):e8055. (PMID: 19956639)
Semin Perinatol. 2009 Jun;33(3):130-7. (PMID: 19464502)
Br J Pharmacol. 2013 Mar;168(5):1074-85. (PMID: 23186152)
Am J Obstet Gynecol. 1999 Feb;180(2 Pt 1):499-506. (PMID: 9988826)
J Reprod Immunol. 2011 Jun;90(1):41-9. (PMID: 21704384)
PPAR Res. 2008;2008:658520. (PMID: 18670616)
J Soc Gynecol Investig. 2005 Jul;12(5):320-9. (PMID: 15979543)
Obstet Gynecol. 2007 Jun;109(6):1368-74. (PMID: 17540809)
Syst Biol Reprod Med. 2015 Apr;61(2):65-71. (PMID: 25475254)
Expert Opin Ther Targets. 2008 Aug;12(8):1049-63. (PMID: 18620525)
Best Pract Res Clin Obstet Gynaecol. 2011 Jun;25(3):273-85. (PMID: 21212025)
Nature. 1988 Mar 31;332(6163):411-5. (PMID: 2451132)
J Perinat Med. 2014 Mar;42(2):179-87. (PMID: 24190593)
Am J Obstet Gynecol. 2011 Mar;204(3):193-201. (PMID: 21094932)
Pregnancy Hypertens. 2012 Apr 1;2(2):72-83. (PMID: 22745921)
J Clin Endocrinol Metab. 2005 Feb;90(2):620-6. (PMID: 15562025)
Hypertension. 2008 Apr;51(4):970-5. (PMID: 18259009)
Obstet Gynecol Surv. 2011 Aug;66(8):497-506. (PMID: 22018452)
Am J Obstet Gynecol. 2019 Sep;221(3):219-226. (PMID: 30738027)
Physiology (Bethesda). 2009 Jun;24:147-58. (PMID: 19509125)
Placenta. 2002 Sep-Oct;23(8-9):661-71. (PMID: 12361685)
Endocrine. 2002 Oct;19(1):103-11. (PMID: 12583607)
Ann N Y Acad Sci. 2002 Nov;973:26-30. (PMID: 12485829)
Am J Pathol. 2010 Nov;177(5):2387-98. (PMID: 20889559)
Placenta. 2014 Feb;35 Suppl:S20-5. (PMID: 24477207)
فهرسة مساهمة: Keywords: Early onset preeclampsia; Late-onset preeclampsia; PPAR-γ; Placenta; Trophoblast
المشرفين على المادة: 0 (PPAR gamma)
تواريخ الأحداث: Date Created: 20200329 Date Completed: 20201217 Latest Revision: 20240727
رمز التحديث: 20240727
مُعرف محوري في PubMed: PMC7099806
DOI: 10.1186/s13104-020-05029-x
PMID: 32216842
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-0500
DOI:10.1186/s13104-020-05029-x