دورية أكاديمية
Molecular domino reactor built by automated modular synthesis for cancer treatment.
| العنوان: | Molecular domino reactor built by automated modular synthesis for cancer treatment. |
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| المؤلفون: | Yang Y; Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China.; Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA., He J; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University Changsha, Hunan, 410082, China., Zhu W; Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China., Pan X; Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA., Yazd HS; Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA., Cui C; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University Changsha, Hunan, 410082, China.; Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA., Yang L; Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA., Li X; Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA., Li L; Department of Chemistry, Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, Florida 32611-7200, USA., Cheng L; Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China., Feng L; Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China., Wang R; Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China., Liu Z; Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China., Chen M; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China., Tan W; Institute of Molecular Medicine (IMM), Renji Hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University Changsha, Hunan, 410082, China. |
| المصدر: | Theranostics [Theranostics] 2020 Mar 04; Vol. 10 (9), pp. 4030-4041. Date of Electronic Publication: 2020 Mar 04 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wyoming, N.S.W. : Ivyspring International Publisher, 2011- |
| مواضيع طبية MeSH: | Aptamers, Nucleotide*/pharmacology , Aptamers, Nucleotide*/therapeutic use , Oligodeoxyribonucleotides*/pharmacology , Oligodeoxyribonucleotides*/therapeutic use , Photochemotherapy* , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/therapeutic use, Neoplasms/*drug therapy , Tumor Hypoxia/*drug effects , Tumor Microenvironment/*drug effects, Animals ; Humans ; Hydrogen Peroxide/metabolism ; MCF-7 Cells ; Mice, Inbred BALB C ; Singlet Oxygen/metabolism |
| مستخلص: | Rationale : A cascade, or domino, reaction consists of two, or more, consecutive reactions such that subsequent reactions occur only if some chemical functionality has first been established in the prior step. However, while construction of predesigned and desired molecular domino reactors in a tailored manner is a valuable endeavor, it is still challenging. Methods : To address this challenge, we herein report an aptamer-based photodynamic domino reactor built through automated modular synthesis. The engineering of this reactor takes advantage of the well-established solid-phase synthesis platform to incorporate a photosensitizer into G-quadruplex/ hemin DNAzyme at the molecular level. Results : As a proof of concept, our photodynamic domino reactor, termed AS1411/hemin- pyrochlorophyll A, achieves in vivo photodynamic domino reaction for efficient cancer treatment by using a high concentration of hydrogen peroxide (H Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).) |
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| فهرسة مساهمة: | Keywords: Automated modular synthesis; Molecular domino reactor; Molecular “elements”; Photodynamic therapy; Tumor microenvironment (TME) |
| المشرفين على المادة: | 0 (AGRO 100) 0 (Aptamers, Nucleotide) 0 (Oligodeoxyribonucleotides) 0 (Photosensitizing Agents) 17778-80-2 (Singlet Oxygen) BBX060AN9V (Hydrogen Peroxide) |
| تواريخ الأحداث: | Date Created: 20200401 Date Completed: 20210518 Latest Revision: 20210518 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7086356 |
| DOI: | 10.7150/thno.43581 |
| PMID: | 32226537 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1838-7640 |
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| DOI: | 10.7150/thno.43581 |