دورية أكاديمية
An in silico analysis of acquired antimicrobial resistance genes in Aeromonas plasmids.
| العنوان: | An in silico analysis of acquired antimicrobial resistance genes in Aeromonas plasmids. |
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| المؤلفون: | Nwaiwu O; School of Biosciences, University of Nottingham, Sutton Bonington Campus, United Kingdom., Aduba CC; Department of Science Laboratory Technology, University of Nigeria, Nsukka, Nigeria. |
| المصدر: | AIMS microbiology [AIMS Microbiol] 2020 Mar 16; Vol. 6 (1), pp. 75-91. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: AIMS Press Country of Publication: United States NLM ID: 101697141 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-1888 (Electronic) Linking ISSN: 24711888 NLM ISO Abbreviation: AIMS Microbiol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Springfield, MO : AIMS Press, [2015]- |
| مستخلص: | Sequences of 105 Aeromonas species plasmids were probed for acquired anti-microbial resistance (AMR) genes using a bioinformatics approach. The plasmids showed no positive linear correlation between size and GC content and up to 55 acquired AMR genes were found in 39 (37%) plasmids after in silico screening for resistance against 15 antibiotic drug classes. Overall, potential multiple antibiotic resistance (p-MAR) index ranged from 0.07 to 0.53. Up to 18 plasmids were predicted to mediate multiple drug resistance (MDR). Plasmids pS121-1a ( A. salmonicida ), pWCX23_1 ( A. hydrophila ) and pASP-a58 ( A. veronii ) harboured 18, 15 and 14 AMR genes respectively. The five most occurring drug classes for which AMR genes were detected were aminoglycosides (27%), followed by beta-lactams (17%), sulphonamides (13%), fluoroquinolones (13%), and phenicols (10%). The most prevalent genes were a sulphonamide resistant gene Sul1 , the gene aac (6')-Ib-cr (aminoglycoside 6'-N-acetyl transferase type Ib-cr) resistant to aminoglycosides and the blaKPC-2 gene, which encodes carbapenemase-production. Plasmid acquisition of AMR genes was mainly inter-genus rather than intra-genus. Eighteen plasmids showed template or host genes acquired from Pseudomonas monteilii , Salmonella enterica or Escherichia coli . The most occurring antimicrobial resistance determinants (ARDs) were beta-lactamase, followed by aminoglycosides acetyl-transferases, and then efflux pumps. Screening of new isolates in vitro and in vivo is required to ascertain the level of phenotypic expression of colistin and other acquired AMR genes detected. Competing Interests: Conflict of interest: Authors declare no conflict of interest. (© 2020 the Author(s), licensee AIMS Press.) |
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| فهرسة مساهمة: | Keywords: Aeromonas; Colistin; GC content; acquired antimicrobial resistance; multiple antimicrobial resistance; plasmids; predicted multidrug resistance |
| تواريخ الأحداث: | Date Created: 20200401 Latest Revision: 20240328 |
| رمز التحديث: | 20240329 |
| مُعرف محوري في PubMed: | PMC7099201 |
| DOI: | 10.3934/microbiol.2020005 |
| PMID: | 32226916 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2471-1888 |
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| DOI: | 10.3934/microbiol.2020005 |