دورية أكاديمية
Proapoptotic Activity of Achillea membranacea Essential Oil and Its Major Constituent 1,8-Cineole against A2780 Ovarian Cancer Cells.
| العنوان: | Proapoptotic Activity of Achillea membranacea Essential Oil and Its Major Constituent 1,8-Cineole against A2780 Ovarian Cancer Cells. |
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| المؤلفون: | Abdalla AN; Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Shaheen U; Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo 11651, Egypt., Abdallah QMA; Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, Taif, Makkah 21974, Saudi Arabia.; Department of Pharmacology & Biomedical Sciences, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman 11196, Jordan., Flamini G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Bkhaitan MM; Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Basic Medical Sciences Unit, Arab American University, Jenin 240, Palestine., Abdelhady MIS; Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo 11651, Egypt., Ascrizzi R; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Bader A; Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2020 Mar 30; Vol. 25 (7). Date of Electronic Publication: 2020 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Eucalyptol*/chemistry , Eucalyptol*/pharmacology , Oils, Volatile*/chemistry , Oils, Volatile*/pharmacology, Achillea/*chemistry , Apoptosis/*drug effects , Ovarian Neoplasms/*drug therapy, Female ; HT29 Cells ; Humans ; MCF-7 Cells ; Ovarian Neoplasms/metabolism ; Ovarian Neoplasms/pathology |
| مستخلص: | Among the hundreds of reported Achillea species, A. membranacea (Labill.) DC. is one of the six that grow in Jordan. Many species of this genus are used in folk medicine to treat a variety of ailments and several biological and pharmacological activities have been ascribed to their essential oil (EO). For this study, the EO obtained from a specimen of A. membranacea grown in Jordan was analyzed by GC-MS. Ninety-six compounds were detected, of which oxygenated monoterpenes was the predominant class (47.9%), followed by non-terpene derivatives (27.9%), while sesquiterpenes represented 14.2% of the total composition. The most abundant compound in the EO was 1,8-cineole (21.7%). The cytotoxic activity of the EO was evaluated against three cancer cell lines (MCF7, A2780 and HT29), and one normal fibroblast cell line (MRC5) by MTT assay. Significant growth inhibition was observed in EO-exposed A2780 and HT29 cells (IC |
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| معلومات مُعتمدة: | 12-MED2310-10 National Plan for Science, Technology and Innovation (MAARIFAH) King Abdulaziz City for Science and Technology, Kingdom of Saudi Arabia |
| فهرسة مساهمة: | Keywords: 1,8-cineole; Asteraceae; GC-EI-MS; apoptosis; cell cycle; cytotoxicity; essential oil |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Oils, Volatile) RV6J6604TK (Eucalyptol) |
| تواريخ الأحداث: | Date Created: 20200403 Date Completed: 20201228 Latest Revision: 20240328 |
| رمز التحديث: | 20240329 |
| مُعرف محوري في PubMed: | PMC7180961 |
| DOI: | 10.3390/molecules25071582 |
| PMID: | 32235558 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules25071582 |