دورية أكاديمية
Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats.
العنوان: | Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats. |
---|---|
المؤلفون: | Zhao YL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China., Su M; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Shang JH; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China.; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China., Wang X; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Njateng GSS; Laboratory of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Bao GL; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Ma J; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Sun QD; Jiangsu Nhwa Pharmaceutical Co., Ltd, Xuzhou, 221009, People's Republic of China., Yuan F; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Wang JK; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China. wjkyimm@163.com., Luo XD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. xdluo@mail.kib.ac.cn.; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. xdluo@mail.kib.ac.cn. |
المصدر: | Natural products and bioprospecting [Nat Prod Bioprospect] 2020 Apr; Vol. 10 (2), pp. 77-88. Date of Electronic Publication: 2020 Mar 31. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 101577734 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2192-2195 (Print) Linking ISSN: 21922209 NLM ISO Abbreviation: Nat Prod Bioprospect Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Heidelberg] : Springer |
مستخلص: | Alstonia scholaris (L.) R. Br. (Apocynaceae) is an evergreen tree that has been used to treat lung diseases. In this study, the toxicity profile of indole alkaloids from leaves of A. scholaris was investigated. In acute toxicity tests, mice were administered total alkaloids (TA) and five indole alkaloids. In a chronic toxicity test, rats were continuously administered TA (50, 100, and 300 mg/kg bw) for 13 weeks, followed by a 4-week recovery. A single administration of TA affected the behavior of mice, and at 12.8 g/kg bw, prone position, shortness of breath, wheezing, and convulsion were observed. The half-lethal dose (LD |
References: | Org Lett. 2007 Apr 26;9(9):1817-20. (PMID: 17391042) Fitoterapia. 2015 Sep;105:160-4. (PMID: 26136061) J Pharm Pharmacol. 2005 Sep;57(9):1213-9. (PMID: 16105243) Phytomedicine. 2017 Apr 15;27:63-72. (PMID: 28314480) Phytomedicine. 2014 Jul-Aug;21(8-9):1120-3. (PMID: 24867504) Nat Prod Bioprospect. 2015 Aug;5(4):185-93. (PMID: 26280886) J Med Assoc Thai. 2015 Mar;98 Suppl 2:S8-15. (PMID: 26211098) J Ethnopharmacol. 2018 Oct 5;224:441-450. (PMID: 29920360) J Chromatogr A. 2012 Mar 2;1227:203-9. (PMID: 22269170) Drug Saf. 2003;26(1):33-48. (PMID: 12495362) J Ethnopharmacol. 2016 Feb 3;178:258-65. (PMID: 26707569) J Ethnopharmacol. 2004 Mar;91(1):43-50. (PMID: 15036466) Evid Based Complement Alternat Med. 2013;2013:256782. (PMID: 23737823) J Ethnopharmacol. 2010 May 27;129(2):174-81. (PMID: 20219658) J Ethnopharmacol. 2018 May 23;218:69-75. (PMID: 29496577) Environ Toxicol. 2017 Feb;32(2):609-618. (PMID: 26996539) Toxicol Lett. 2004 Jul 15;151(2):317-26. (PMID: 15183456) BMC Complement Altern Med. 2016 Jul 27;16:249. (PMID: 27460904) Org Lett. 2016 Feb 19;18(4):654-7. (PMID: 26800290) J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jul 15;1026:43-55. (PMID: 26275898) J Ethnopharmacol. 2010 Jun 16;129(3):293-8. (PMID: 20381600) Planta Med. 2009 Nov;75(14):1537-41. (PMID: 19609839) J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Nov 1;908:98-104. (PMID: 23122407) Regul Toxicol Pharmacol. 2018 Apr;94:144-151. (PMID: 29407176) Org Lett. 2008 Feb 21;10(4):577-80. (PMID: 18205369) Lab Anim Res. 2012 Jun;28(2):115-21. (PMID: 22787485) Org Lett. 2014 Nov 7;16(21):5808-11. (PMID: 25353160) |
معلومات مُعتمدة: | 2017YFC1704007 National Science and Technology Program during the Twelfth Five-year Plan Period (CN) |
فهرسة مساهمة: | Keywords: Acute toxicity; Alstonia scholaris; Chronic toxicity; Indole alkaloids; Non-observed-adverse-effect-level |
تواريخ الأحداث: | Date Created: 20200403 Latest Revision: 20240328 |
رمز التحديث: | 20240329 |
مُعرف محوري في PubMed: | PMC7176796 |
DOI: | 10.1007/s13659-020-00237-1 |
PMID: | 32236848 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2192-2195 |
---|---|
DOI: | 10.1007/s13659-020-00237-1 |