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Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats.

التفاصيل البيبلوغرافية
العنوان: Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats.
المؤلفون: Zhao YL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China., Su M; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Shang JH; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China.; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China., Wang X; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Njateng GSS; Laboratory of Microbiology and Antimicrobial Substances, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Bao GL; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Ma J; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Sun QD; Jiangsu Nhwa Pharmaceutical Co., Ltd, Xuzhou, 221009, People's Republic of China., Yuan F; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China., Wang JK; Yunnan Institute of Medical Material, Kunming, 650111, People's Republic of China. wjkyimm@163.com., Luo XD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. xdluo@mail.kib.ac.cn.; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China. xdluo@mail.kib.ac.cn.
المصدر: Natural products and bioprospecting [Nat Prod Bioprospect] 2020 Apr; Vol. 10 (2), pp. 77-88. Date of Electronic Publication: 2020 Mar 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101577734 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2192-2195 (Print) Linking ISSN: 21922209 NLM ISO Abbreviation: Nat Prod Bioprospect Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Heidelberg] : Springer
مستخلص: Alstonia scholaris (L.) R. Br. (Apocynaceae) is an evergreen tree that has been used to treat lung diseases. In this study, the toxicity profile of indole alkaloids from leaves of A. scholaris was investigated. In acute toxicity tests, mice were administered total alkaloids (TA) and five indole alkaloids. In a chronic toxicity test, rats were continuously administered TA (50, 100, and 300 mg/kg bw) for 13 weeks, followed by a 4-week recovery. A single administration of TA affected the behavior of mice, and at 12.8 g/kg bw, prone position, shortness of breath, wheezing, and convulsion were observed. The half-lethal dose (LD 50 ) in mice was 5.48 g/kg bw, almost 2740 times the clinical dose in humans. Among the five indole alkaloids, the maximum tolerance dose in mice ranged from 0.75 to 4 g/kg bw. The TA-treated rats did not die and showed no adverse effects or dose-dependent changes in weight or food and water consumption, despite fluctuations in hematological and biochemical parameters compared with historical data. Furthermore, both gross and histopathological observations revealed no abnormalities in any organ. With daily oral administration to rats, the non-observed-adverse-effect-level of TA was 100 mg/kg bw. The results indicate that TA is safe for clinical use.
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معلومات مُعتمدة: 2017YFC1704007 National Science and Technology Program during the Twelfth Five-year Plan Period (CN)
فهرسة مساهمة: Keywords: Acute toxicity; Alstonia scholaris; Chronic toxicity; Indole alkaloids; Non-observed-adverse-effect-level
تواريخ الأحداث: Date Created: 20200403 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC7176796
DOI: 10.1007/s13659-020-00237-1
PMID: 32236848
قاعدة البيانات: MEDLINE
الوصف
تدمد:2192-2195
DOI:10.1007/s13659-020-00237-1