دورية أكاديمية
αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish.
العنوان: | αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish. |
---|---|
المؤلفون: | Rybin MJ; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami, Miller School of Medicine, Miami, FL 33136, USA., O'Brien H; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA., Ramiro IBL; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Azam L; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA., McIntosh JM; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.; George E. Whalen Veterans Affairs Medical Center, Salt Lake City, UT 84112, USA.; Department of Psychiatry, University of Utah, Salt Lake City, UT 84112, USA., Olivera BM; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA., Safavi-Hemami H; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA.; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA., Yoshikami D; Department of Biology, University of Utah, Salt Lake City, UT 84112, USA. |
المصدر: | Toxins [Toxins (Basel)] 2020 Mar 21; Vol. 12 (3). Date of Electronic Publication: 2020 Mar 21. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel : MDPI |
مواضيع طبية MeSH: | Conotoxins/*pharmacology , Muscle, Skeletal/*drug effects , Neuromuscular Junction/*drug effects , Nicotinic Antagonists/*pharmacology , Receptors, Nicotinic/*metabolism, Action Potentials/drug effects ; Amino Acid Sequence ; Animals ; Conotoxins/chemistry ; Dose-Response Relationship, Drug ; Excitatory Postsynaptic Potentials/drug effects ; Goldfish ; Mice ; Muscle, Skeletal/metabolism ; Neuromuscular Junction/metabolism ; Nicotinic Antagonists/chemistry ; Paresis/chemically induced ; Predatory Behavior/drug effects ; Protein Binding ; Sequence Alignment ; Species Specificity ; Xenopus laevis |
مستخلص: | We report the discovery and functional characterization of αM-Conotoxin MIIIJ, a peptide from the venom of the fish-hunting cone snail Conus magus . Injections of αM-MIIIJ induced paralysis in goldfish ( Carassius auratus ) but not mice. Intracellular recording from skeletal muscles of fish ( C. auratus ) and frog ( Xenopus laevis ) revealed that αM-MIIIJ inhibited postsynaptic nicotinic acetylcholine receptors (nAChRs) with an IC |
References: | Expert Opin Biol Ther. 2011 Nov;11(11):1469-84. (PMID: 21939428) Mol Biol Cell. 1997 Nov;8(11):2101-9. (PMID: 9362055) J Neurosci. 2001 Aug 1;21(15):5439-48. (PMID: 11466415) Biochemistry. 1995 Apr 25;34(16):5364-71. (PMID: 7727394) Brain Behav Evol. 2015 Sep;86(1):58-74. (PMID: 26397110) J Physiol. 1974 Mar;237(2):385-400. (PMID: 4133039) J Neurosci. 2000 Jan 1;20(1):76-80. (PMID: 10627583) J Biol Chem. 1995 Jul 14;270(28):16796-802. (PMID: 7622492) Br J Pharmacol. 2012 Jul;166(5):1654-68. (PMID: 22229737) Biochem Pharmacol. 2015 Aug 15;96(4):349-56. (PMID: 26074268) J Physiol. 1975 Jan;244(3):703-30. (PMID: 166160) J Physiol. 1981 Feb;311:307-24. (PMID: 6267255) Toxicon. 2009 Jan;53(1):90-8. (PMID: 18950653) Science. 2017 Sep 22;357(6357):1261-1266. (PMID: 28935799) J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Sep;203(9):717-735. (PMID: 28551870) J Biol Chem. 2002 Sep 13;277(37):33610-5. (PMID: 12114524) Sci Rep. 2018 Jan 17;8(1):1004. (PMID: 29343689) J Biol Chem. 2005 Jan 7;280(1):80-7. (PMID: 15520009) Arch Biochem Biophys. 1959 May;82(1):70-7. (PMID: 13650640) Comp Biochem Physiol A Mol Integr Physiol. 2003 Jul;135(3):435-42. (PMID: 12829051) Biochemistry. 1997 Aug 5;36(31):9581-7. (PMID: 9236004) J Biol Chem. 1997 Sep 5;272(36):22531-7. (PMID: 9278406) Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10302-7. (PMID: 21652775) J Neurophysiol. 1999 Jun;81(6):2852-61. (PMID: 10368402) Biochemistry. 1987 Apr 21;26(8):2086-90. (PMID: 2441741) Anal Bioanal Chem. 2013 Jun;405(15):5341-51. (PMID: 23584713) FEBS J. 2007 Aug;274(15):3972-85. (PMID: 17635581) FEBS Lett. 1983 May 8;155(2):277-80. (PMID: 6852238) Biochemistry. 1999 May 11;38(19):6317-26. (PMID: 10320362) Biochemistry. 2007 Jul 31;46(30):8717-24. (PMID: 17608455) J Neurosci. 2003 Nov 19;23(33):10467-74. (PMID: 14627630) Br J Pharmacol. 1997 Mar;120(6):995-1000. (PMID: 9134208) J Neurophysiol. 2001 Dec;86(6):2951-6. (PMID: 11731551) J Biol Chem. 2003 Jan 31;278(5):3137-44. (PMID: 12419800) J Neurophysiol. 1996 Sep;76(3):1423-9. (PMID: 8890263) J Gen Physiol. 2011 Sep;138(3):353-66. (PMID: 21844221) Biochemistry. 2003 Jun 3;42(21):6353-62. (PMID: 12767216) Biochemistry. 2006 Jun 13;45(23):7404-14. (PMID: 16752929) Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17030-5. (PMID: 17077153) Physiol Rev. 2004 Jan;84(1):41-68. (PMID: 14715910) Acta Biochim Biophys Sin (Shanghai). 2007 Jun;39(6):438-44. (PMID: 17558449) J Biol Chem. 1995 Sep 22;270(38):22361-7. (PMID: 7673220) Biochemistry. 2005 May 31;44(21):7897-902. (PMID: 15910004) J Neurocytol. 1987 Aug;16(4):567-76. (PMID: 3500278) Chem Rec. 2007;7(6):341-53. (PMID: 18050267) Mol Pharmacol. 1995 Aug;48(2):194-9. (PMID: 7651351) J Biol Chem. 2005 Aug 26;280(34):30107-12. (PMID: 15983035) Cell Mol Life Sci. 2010 Jan;67(1):17-27. (PMID: 19705062) Curr Top Membr. 2016;78:65-86. (PMID: 27586281) J Neurosci. 2003 Sep 17;23(24):8445-52. (PMID: 13679412) Nature. 1984 Mar 15-21;308(5956):282-4. (PMID: 6608056) J Neurochem. 2003 May;85(3):610-21. (PMID: 12694387) Mol Pharmacol. 1995 Jul;48(1):105-11. (PMID: 7623764) Cell Biosci. 2015 Nov 14;5:62. (PMID: 26568818) Anal Biochem. 1970 Apr;34(2):595-8. (PMID: 5443684) J Proteomics. 2019 Jan 6;190:12-20. (PMID: 29777871) Toxins (Basel). 2018 Dec 01;10(12):. (PMID: 30513724) Biochemistry. 2005 May 17;44(19):7259-65. (PMID: 15882064) J Neurosci. 1998 Jun 15;18(12):4473-81. (PMID: 9614224) Biochemistry. 1992 Oct 20;31(41):9919-26. (PMID: 1390774) Toxicon. 2013 Aug;70:170-8. (PMID: 23668937) Biochemistry. 1988 Sep 6;27(18):7102-5. (PMID: 3196703) Toxicon. 2008 Feb;51(2):174-80. (PMID: 18054976) Bull World Health Organ. 1965;32(1):143-4. (PMID: 20604205) J Biol Chem. 1981 May 25;256(10):4734-40. (PMID: 7014556) Biochemistry. 1995 Nov 7;34(44):14519-26. (PMID: 7578057) Biochem Biophys Res Commun. 2017 Jan 22;482(4):1135-1140. (PMID: 27916464) J Proteomics. 2012 Sep 18;75(17):5215-25. (PMID: 22705119) J Biol Chem. 1996 Mar 29;271(13):7522-8. (PMID: 8631783) PLoS One. 2013 May 22;8(5):e64655. (PMID: 23717646) Mar Drugs. 2014 Dec 17;12(12):6058-101. (PMID: 25522317) Biochemistry. 2006 Mar 21;45(11):3723-32. (PMID: 16533055) Biochemistry. 2006 Jan 31;45(4):1304-12. (PMID: 16430227) Arch Biochem Biophys. 1982 Oct 1;218(1):329-34. (PMID: 7149738) Biochemistry. 2004 Dec 28;43(51):16019-26. (PMID: 15609996) J Biol Chem. 2003 Jan 10;278(2):757-64. (PMID: 12384509) Biochemistry. 1991 Sep 24;30(38):9370-7. (PMID: 1892838) Science. 1992 Jan 10;255(5041):200-3. (PMID: 1553547) J Mol Biol. 1990 Oct 5;215(3):403-10. (PMID: 2231712) Toxicon. 2004 Aug;44(2):207-14. (PMID: 15246771) Toxicon. 2007 Jun 15;49(8):1193-9. (PMID: 17382984) Neurosci Lett. 1987 Nov 10;82(1):83-8. (PMID: 2962016) |
معلومات مُعتمدة: | P01 GM048677 United States GM NIGMS NIH HHS; 19063 International Velux Foundation; GM048677 United States NH NIH HHS |
فهرسة مساهمة: | Keywords: conotoxin; neuromuscular junction; nicotinic acetylcholine receptor; venom |
المشرفين على المادة: | 0 (Conotoxins) 0 (Nicotinic Antagonists) 0 (Receptors, Nicotinic) |
تواريخ الأحداث: | Date Created: 20200405 Date Completed: 20210305 Latest Revision: 20210305 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7150935 |
DOI: | 10.3390/toxins12030197 |
PMID: | 32245200 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6651 |
---|---|
DOI: | 10.3390/toxins12030197 |