دورية أكاديمية
أعرض في EDS

Distinct inactivated bacterial-based immune modulators vary in their therapeutic efficacies for treating disease based on the organ site of pathology.

التفاصيل البيبلوغرافية
العنوان: Distinct inactivated bacterial-based immune modulators vary in their therapeutic efficacies for treating disease based on the organ site of pathology.
المؤلفون: Kalyan S; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada., Bazett M; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada., Sham HP; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada., Bosiljcic M; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada., Luk B; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada., Dhanji S; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada., Costa AM; Department of Microbiology and Immunology and Department of Medical Education, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA., Wong SWY; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada., Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Mullins DW; Department of Microbiology and Immunology and Department of Medical Education, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA., Gunn H; Qu Biologics Inc., Burnaby, BC, V5G 4X4, Canada. hal@qubiologics.com.
المصدر: Scientific reports [Sci Rep] 2020 Apr 03; Vol. 10 (1), pp. 5901. Date of Electronic Publication: 2020 Apr 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Immunity, Innate*, Bacterial Vaccines/*immunology , Cancer Vaccines/*immunology , Immunotherapy/*methods , Neoplasms/*therapy, Adaptive Immunity ; Animals ; Bacterial Vaccines/administration & dosage ; Cancer Vaccines/administration & dosage ; Cell Line, Tumor/transplantation ; Disease Models, Animal ; Female ; Humans ; Immunogenicity, Vaccine ; Immunologic Memory ; Injections, Subcutaneous ; Mice ; Neoplasms/immunology ; Treatment Outcome ; Vaccines, Inactivated/administration & dosage ; Vaccines, Inactivated/immunology
مستخلص: Recent developments in understanding how the functional phenotype of the innate immune system is programmed has led to paradigm-shifting views on immunomodulation. These advances have overturned two long-held dogmas: (1) only adaptive immunity confers immunological memory; and, (2) innate immunity lacks specificity. This work describes the observation that innate immune effector cells appear to be differentially recruited to specific pathological sites when mobilized by distinct inactivated bacterial-based stimuli administered subcutaneously. The studies presented suggest that the immune system, upon detecting the first signs of a potential infection by a specific pathogen, tends to direct its resources to the compartment from which that pathogen is most likely originating. The findings from this work puts forth the novel hypothesis that the immunotherapeutic efficacy of a microbial-based stimulus for innate immune mobilization depends on the correct selection of the microbial species used as the stimulant and its relationship to the organ in which the pathology is present.
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معلومات مُعتمدة: P30 CA023108 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Bacterial Vaccines)
0 (Cancer Vaccines)
0 (Vaccines, Inactivated)
تواريخ الأحداث: Date Created: 20200405 Date Completed: 20201207 Latest Revision: 20210403
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7125210
DOI: 10.1038/s41598-020-62735-z
PMID: 32246043
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-020-62735-z