دورية أكاديمية
The effect of vitamin E and C on comet assay indices and apoptosis in power plant workers: A double blind randomized controlled clinical trial.
| العنوان: | The effect of vitamin E and C on comet assay indices and apoptosis in power plant workers: A double blind randomized controlled clinical trial. |
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| المؤلفون: | Bagheri Hosseinabadi M; School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran., Khanjani N; Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran., Atashi A; School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Norouzi P; School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Mirbadie SR; School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Mirzaii M; School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. Electronic address: mirzaii1386@gmail.com. |
| المصدر: | Mutation research. Genetic toxicology and environmental mutagenesis [Mutat Res Genet Toxicol Environ Mutagen] 2020 Feb - Mar; Vol. 850-851, pp. 503150. Date of Electronic Publication: 2020 Feb 04. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101632149 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3592 (Electronic) Linking ISSN: 13835718 NLM ISO Abbreviation: Mutat Res Genet Toxicol Environ Mutagen Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, 1997- |
| مواضيع طبية MeSH: | Antioxidants/*administration & dosage , Ascorbic Acid/*administration & dosage , DNA Damage/*drug effects , Vitamin E/*administration & dosage, Adult ; Apoptosis/drug effects ; DNA Damage/genetics ; Double-Blind Method ; Flow Cytometry ; Humans ; Iran ; Lymphocytes/drug effects ; Lymphocytes/pathology ; Magnetic Fields/adverse effects ; Male ; Power Plants |
| مستخلص: | Extremely low frequency electromagnetic fields have been classified as a possible human carcinogen by the International Agency for Research on Cancer and this has raised some concern about its health effects on employees extensively exposed to these fields at thermal power plants. In this study, the effect of using vitamin E and C supplements have been examined on employees working at a thermal power plant. In this randomized controlled, double-blind clinical trial, 81 employees from different parts of the thermal power plant were enrolled between July and November 2017, and divided into four groups: Group 1 received vitamin E (400 units/day), Group 2: vitamin C (1000 mg/day), Group 3: vitamin E + C and Group 4: no intervention. DNA damage was measured in peripheral blood lymphocytes using comet assay and apoptosis, using flow cytometry. Based on the results, tail intensity and tail length in the vitamin E group, and all comet assay indices in the vitamin E + C and vitamin C groups (except DNA damage index) significantly decreased after the intervention, while the comet assay indices did not change significantly in the control group. None of the flow cytometry indices including early apoptosis, late apoptosis and necrosis changed after intervention in either group. The use of antioxidant vitamins such as E and C, can increase the activity of the non-enzymatic antioxidant defense system, and protect DNA from damage caused by exposure to extremely low frequency magnetic fields. But, taking these vitamins has no effect on apoptosis. It seems that consumption of vitamin E affected all investigated comet assay indices and can be probably considered as the best intervention. Competing Interests: Declaration of Competing Interest None. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Comet assay; Flow cytometry; Non-enzymatic antioxidant defense system |
| المشرفين على المادة: | 0 (Antioxidants) 1406-18-4 (Vitamin E) PQ6CK8PD0R (Ascorbic Acid) |
| تواريخ الأحداث: | Date Created: 20200406 Date Completed: 20200424 Latest Revision: 20210920 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.mrgentox.2020.503150 |
| PMID: | 32247559 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-3592 |
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| DOI: | 10.1016/j.mrgentox.2020.503150 |