دورية أكاديمية
أعرض في EDS

Elevated miR-9 in Cerebrospinal Fluid Is Associated with Poor Functional Outcome After Subarachnoid Hemorrhage.

التفاصيل البيبلوغرافية
العنوان: Elevated miR-9 in Cerebrospinal Fluid Is Associated with Poor Functional Outcome After Subarachnoid Hemorrhage.
المؤلفون: Bache S; Department of Neuroanaesthesiology, The Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark. bache@dadlnet.dk.; Centre for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark. bache@dadlnet.dk.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. bache@dadlnet.dk., Rasmussen R; Department of Neurosurgery, The Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark., Wolcott Z; Department of Neurology & Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Rossing M; Centre for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark., Møgelvang R; Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark., Tolnai D; Department of Radiology, The Diagnostic Centre, Rigshospitalet, Copenhagen, Denmark., Hassager C; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark., Forman JL; Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Køber L; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen, Denmark., Nielsen FC; Centre for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Kimberly WT; Department of Neurology & Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Møller K; Department of Neuroanaesthesiology, The Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
المصدر: Translational stroke research [Transl Stroke Res] 2020 Dec; Vol. 11 (6), pp. 1243-1252. Date of Electronic Publication: 2020 Apr 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101517297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-601X (Electronic) Linking ISSN: 18684483 NLM ISO Abbreviation: Transl Stroke Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Springer
مواضيع طبية MeSH: Recovery of Function*, Biomarkers/*cerebrospinal fluid , MicroRNAs/*cerebrospinal fluid , Subarachnoid Hemorrhage/*cerebrospinal fluid, Adult ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Prognosis
مستخلص: This study evaluated microRNA (miRNA) changes in cerebrospinal fluid (CSF) and their association with the occurrence of delayed cerebral ischemia (DCI) and poor functional outcome after SAH. Forty-three selected miRNAs were measured in daily CSF samples from a discovery cohort of SAH patients admitted to Rigshospitalet, Copenhagen, Denmark, and compared with neurologically healthy patients. Findings were validated in CSF from a replication cohort of SAH patients admitted to Massachusetts General Hospital, Boston, Massachusetts. The CSF levels of miRNA over time were compared with the occurrence of DCI, and functional outcome after 3 months. miRNAs were quantified in 427 CSF samples from 63 SAH patients in the discovery cohort, in 104 CSF samples from 63 SAH patients in the replication cohort, and in 11 CSF samples from 11 neurologically healthy patients. The miRNA profile changed remarkably immediately after SAH. Elevated miR-9-3p was associated with a poor functional outcome in the discovery cohort (p < 0.0001) after correction for multiple testing (q < 0.01) and in the replication cohort (p < 0.01). Furthermore, elevated miR-9-5p was associated with a poor functional outcome in the discovery cohort (p < 0.01) after correction for multiple testing (q < 0.05). No miRNA was associated with DCI in both cohorts. miR-9-3p and miR-9-5p are elevated in the CSF following SAH and this elevation is associated with a poor functional outcome. These elevations have potential roles in the progression of cerebral injury and could add to early prognostication.
معلومات مُعتمدة: R212-2015-1987 International Lundbeckfonden; R211-2015-3844 International Lundbeckfonden (DK)
فهرسة مساهمة: Keywords: Cerebrospinal fluid; MicroRNA; Stroke; Subarachnoid hemorrhage
المشرفين على المادة: 0 (Biomarkers)
0 (MIRN92 microRNA, human)
0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20200406 Date Completed: 20211014 Latest Revision: 20211014
رمز التحديث: 20231215
DOI: 10.1007/s12975-020-00793-1
PMID: 32248435
قاعدة البيانات: MEDLINE
الوصف
تدمد:1868-601X
DOI:10.1007/s12975-020-00793-1