دورية أكاديمية
Carica papaya attenuates testicular histomorphological and hormonal alterations following alcohol-induced gonado toxicity in male rats.
| العنوان: | Carica papaya attenuates testicular histomorphological and hormonal alterations following alcohol-induced gonado toxicity in male rats. |
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| المؤلفون: | Asuquo IE; Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, PMB 1017, Uyo, 520001 Nigeria., Edagha IA; Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, PMB 1017, Uyo, 520001 Nigeria., Ekandem GJ; Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, PMB 1017, Uyo, 520001 Nigeria., Peter AI; Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, PMB 1017, Uyo, 520001 Nigeria. |
| المصدر: | Toxicological research [Toxicol Res] 2019 Nov 21; Vol. 36 (2), pp. 149-157. Date of Electronic Publication: 2019 Nov 21 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101483324 Publication Model: eCollection Cited Medium: Print ISSN: 1976-8257 (Print) Linking ISSN: 19768257 NLM ISO Abbreviation: Toxicol Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Singapore : Springer Singapore Original Publication: Seoul : Korean Society of Toxicology |
| مستخلص: | Chronic alcohol consumption has been implicated in male infertility, whereas Carica papaya (CP) ripe fruit possesses antioxidant activity. This study investigated histomorphological and hormonal effects of ripened CP in alcohol experimental model. Thirty Wistar rats were divided into six groups of five animals each as follows; groups 1, 2 and 3 received distilled water 2 ml, 40% ethanol 5 ml, and 40% ethanol 5 ml + 50 mg Clomiphene citrate/kg body weight, respectively, while groups 4, 5 and 6 received 40% ethanol 5 ml + CP 500, 1000 and 1500 mg/kg body weight, respectively. Sperm counts and motility were significantly decreased ( p < 0.05) in group 2 compared to group 1. Testosterone significantly increased ( p < 0.05) in CP-treated groups, and luteinizing hormone was significantly reduced ( p < 0.05) compared to the control. Group 2 showed spermatogenic cell distortions which were ameliorated in the CP-treated groups. CP exerted testicular protective potential against ethanol-induced testicular toxicity plausibly via its antioxidant mechanism. Competing Interests: Conflict of interestThe authors declare that they have no conflict of interest. (© Korean Society of Toxicology 2019.) |
| References: | Inflammopharmacology. 2008 Aug;16(4):168-73. (PMID: 18759075) Oncology. 1997 Jan-Feb;54(1):74-8. (PMID: 8978597) Mol Nutr Food Res. 2007 Jan;51(1):116-34. (PMID: 17195249) Eur Urol. 2012 Aug;62(2):324-32. (PMID: 22591628) Niger J Physiol Sci. 2013 Jun 30;28(1):9-15. (PMID: 23955400) J Ethnopharmacol. 2010 Feb 17;127(3):760-7. (PMID: 19961915) Mol Reprod Dev. 1995 Nov;42(3):334-46. (PMID: 8579848) J Nat Prod. 2000 Jul;63(7):1035-42. (PMID: 10924197) Fertil Steril. 2005 Oct;84(4):919-24. (PMID: 16213844) Fertil Steril. 2003 Jan;79(1):203-5. (PMID: 12524089) J Biol Chem. 2005 Sep 16;280(37):32090-100. (PMID: 16024922) Urology. 1996 Dec;48(6):835-50. (PMID: 8973665) J Ethnopharmacol. 2005 Jul 14;99(3):317-24. (PMID: 15978760) Rev Lat Am Enfermagem. 2015 May-Jun;23(3):458-65. (PMID: 26155004) J Ethnopharmacol. 2004 Jun;92(2-3):311-6. (PMID: 15138017) J Agric Food Chem. 2008 Sep 24;56(18):8326-33. (PMID: 18717569) FASEB J. 1999 Dec;13(15):2138-42. (PMID: 10593860) Hum Reprod. 2009 Nov;24(11):2683-7. (PMID: 19801627) Arch Toxicol. 1983 Dec;54(4):275-87. (PMID: 6667118) Crit Rev Food Sci Nutr. 2011 Jul;51(6):563-70. (PMID: 21929332) Am J Clin Nutr. 2001 Oct;74(4):418-25. (PMID: 11566638) Asian J Androl. 2002 Mar;4(1):17-26. (PMID: 11907624) West Afr J Med. 2007 Jul-Sep;26(3):217-21. (PMID: 18399338) Phytochemistry. 2002 Aug;60(8):873-82. (PMID: 12150815) Br J Nutr. 2002 Jan;87(1):55-9. (PMID: 11898770) |
| فهرسة مساهمة: | Keywords: Alcohol; Carica papaya; Sex hormones; Sperm; Testicular toxicity |
| تواريخ الأحداث: | Date Created: 20200408 Latest Revision: 20231113 |
| رمز التحديث: | 20231113 |
| مُعرف محوري في PubMed: | PMC7099107 |
| DOI: | 10.1007/s43188-019-00017-1 |
| PMID: | 32257927 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. | تدمد: | 1976-8257 |
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| DOI: | 10.1007/s43188-019-00017-1 |