دورية أكاديمية
أعرض في EDS

Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.

التفاصيل البيبلوغرافية
العنوان: Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.
المؤلفون: McCracken MK; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Gromowski GD; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Garver LS; Entomology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Goupil BA; Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America., Walker KD; Entomology Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Friberg H; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Currier JR; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Rutvisuttinunt W; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Hinton KL; Veterinary Services Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Christofferson RC; Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America., Mores CN; Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, Louisiana, United States of America., Vanloubbeeck Y; GSK Vaccines, Rixensart, Belgium., Lorin C; GSK Vaccines, Rixensart, Belgium., Malice MP; GSK Vaccines, Rixensart, Belgium., Thomas SJ; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Jarman RG; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Vaughn DW; GSK Vaccines, Rockville, Maryland, United States of America., Putnak JR; Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America., Warter L; GSK Vaccines, Rixensart, Belgium.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Apr 08; Vol. 14 (4), pp. e0008191. Date of Electronic Publication: 2020 Apr 08 (Print Publication: 2020).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Antibodies, Neutralizing/*blood , Antibodies, Viral/*blood , Dengue/*immunology, Animals ; Dengue/virology ; Dengue Virus/physiology ; Disease Models, Animal ; Female ; Kinetics ; Macaca mulatta/immunology ; Mosquito Vectors/virology ; RNA, Viral/blood ; Salivary Glands/virology ; Vaccination ; Viral Load ; Viremia/prevention & control ; Virus Replication
مستخلص: Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were exposed to DENV-1 via subcutaneous or intradermal inoculation of virus only, intradermal inoculation of virus and salivary gland extract, or infectious mosquito feeding. The infectious mosquito feeding group exhibited delayed onset of viremia, greater viral loads, and altered clinical and immune responses compared to other groups. After 15 months, NHPs in the subcutaneous and infectious mosquito feeding groups were re-exposed to either DENV-1 or DENV-2. Viral replication and neutralizing antibody following homologous challenge were suggestive of sterilizing immunity, whereas heterologous challenge resulted in productive, yet reduced, DENV-2 replication and boosted neutralizing antibody. These results show that a more transmission-relevant exposure modality resulted in viral replication closer to that observed in humans.
Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, David Vaughn, and Lucile Warter are employees of the GSK group of companies.
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المشرفين على المادة: 0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (RNA, Viral)
تواريخ الأحداث: Date Created: 20200409 Date Completed: 20200706 Latest Revision: 20200706
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7141610
DOI: 10.1371/journal.pntd.0008191
PMID: 32267846
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0008191