Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma.

التفاصيل البيبلوغرافية
العنوان:	Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma.
المؤلفون:	Barros-Silva PG; Department of Dentistry Unichristus, Rua João Adolfo Gurgel 133 Aldeota, 60160-196, Fortaleza, Ceará, Brazil paulo_goberlanio@yahoo.com.br., Fontes-Borges MM, Costa-Dias C, Mota-Lemos JV, Socorro-Saldanha-Cunha MD, Fernandes-Souza E, Sousa-Dantas T, Bitu-Sousa F
المصدر:	Medicina oral, patologia oral y cirugia bucal [Med Oral Patol Oral Cir Bucal] 2020 May 01; Vol. 25 (3), pp. e375-e382. Date of Electronic Publication: 2020 May 01.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Medicina Oral S.L Country of Publication: Spain NLM ID: 101231694 Publication Model: Electronic Cited Medium: Internet ISSN: 1698-6946 (Electronic) Linking ISSN: 16984447 NLM ISO Abbreviation: Med Oral Patol Oral Cir Bucal Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Valencia, España : Medicina Oral S.L., [2004]-
مواضيع طبية MeSH:	Carcinoma, Squamous Cell* , Head and Neck Neoplasms* , Oropharyngeal Neoplasms*, Aged ; Cross-Sectional Studies ; Humans ; Male ; Neoplasm Staging ; Prognosis ; Retrospective Studies
مستخلص:	Background: The objective of this study was to evaluate the influence of clinical-pathological and sociodemographic factors on the prevalence of distant metastasis (DM) and overall survival in patients with oral cavity and oropharynx squamous cell carcinoma (OOSCC). Material and Methods: Cross-sectional study based on the records of 404 OOSCC patients evaluated for DM, covering the period 2000-2014. We analysed the influence of age, sex, level of schooling, primary tumor subsite, treatment, marital status, family history of cancer, history of smoking and alcohol consumption, type of health care coverage (private vs. public) and overall survival. Findings were submitted to Fisher's exact test, Pearson's chi-squared test, Mantel-Cox log-rank testing and multinomial and Cox regression analysis (SPSS v. 20.0; p<0.05). Results: The prevalence of DM was 5.4% (22/404). The respiratory tract was the most affected DM site (n=9; 40.9%). Male sex (p=0.049), oropharyngeal primary tumor (p=0.008), stage T3-4 (p=0.022), lymph node metastasis (N+) (p<0.001) and palliative treatment (p=0.005) were directly associated with DM. Patients with oral primary tumours (p=0.343) and primary oropharyngeal tumours (p=0.242) did not differ significantly with regard to the prevalence of DM. N+ was an independent risk factor for DM (p=0.017). Five variables independently reduced overall survival: male sex (p=0.035), age >65 years (p=0.046), indigenous/brown racial type (p=0.045), palliative treatment (p=0.035) and DM (p=0.048). Conclusions: Lymph node metastasis independently increased the prevalence of DM and, along with male sex, older age, brown racial type and palliative treatment, was independently associated with poor prognosis in patients with OOSCC.
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تواريخ الأحداث:	Date Created: 20200410 Date Completed: 20200414 Latest Revision: 20200516
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC7211363
DOI:	10.4317/medoral.23410
PMID:	32271320
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1698-6946
DOI:	10.4317/medoral.23410