دورية أكاديمية
أعرض في EDS

A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae .

التفاصيل البيبلوغرافية
العنوان: A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae .
المؤلفون: Ferron F; Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix-Marseille Université, UMR 7257, Polytech Case 925, 13009 Marseille, France.; European Virus Bioinformatics Center, Leutragraben 1, 07743 Jena, Germany., Debat HJ; Instituto de Patología Vegetal, Centro de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria, X5119 Córdoba, Argentina., Shannon A; Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix-Marseille Université, UMR 7257, Polytech Case 925, 13009 Marseille, France., Decroly E; Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix-Marseille Université, UMR 7257, Polytech Case 925, 13009 Marseille, France., Canard B; Architecture et Fonction des Macromolécules Biologiques, CNRS and Aix-Marseille Université, UMR 7257, Polytech Case 925, 13009 Marseille, France.; European Virus Bioinformatics Center, Leutragraben 1, 07743 Jena, Germany.
المصدر: NAR genomics and bioinformatics [NAR Genom Bioinform] 2020 Mar; Vol. 2 (1), pp. lqz022. Date of Electronic Publication: 2019 Dec 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101756213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2631-9268 (Electronic) Linking ISSN: 26319268 NLM ISO Abbreviation: NAR Genom Bioinform Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Oxford University Press, [2019]-
مستخلص: The order Nidovirales is a diverse group of (+)RNA viruses, classified together based on their common genome organisation and conserved replicative enzymes, despite drastic differences in size and complexity. One such difference pertains to the mechanisms and enzymes responsible for generation of the proposed viral 5' RNA cap. Within the Coronaviridae family, two separate methytransferases (MTase), nsp14 and nsp16, perform the RNA-cap N7-guanine and 2'-OH methylation respectively for generation of the proposed m7GpppNm type I cap structure. For the majority of other families within the Nidovirales order, the presence, structure and key enzymes involved in 5' capping are far less clear. These viruses either lack completely an RNA MTase signature sequence, or lack an N7-guanine methyltransferase signature sequence, obscuring our understanding about how RNA-caps are N7-methylated for these families. Here, we report the discovery of a putative Rossmann fold RNA methyltransferase in 10  Tobaniviridae members in Orf1a, an unusual genome locus for this gene. Multiple sequence alignments and structural analyses lead us to propose this novel gene as a typical RNA-cap N7-guanine MTase with substrate specificity and active-site organization similar to the canonical eukaryotic RNA-cap N7-guanine MTase.
(© The Author(s) 2019. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.)
References: Nucleic Acids Res. 2018 Sep 6;46(15):7902-7912. (PMID: 30192980)
J Comput Chem. 2004 Oct;25(13):1605-12. (PMID: 15264254)
Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):507-11. (PMID: 7831320)
J Mol Biol. 1973 May 15;76(2):241-56. (PMID: 4737475)
Virus Res. 2006 Apr;117(1):17-37. (PMID: 16503362)
Nucleic Acids Res. 2016 Sep 19;44(16):7511-26. (PMID: 27317694)
Genome Res. 2004 Jun;14(6):1188-90. (PMID: 15173120)
PLoS Pathog. 2018 Nov 1;14(11):e1007314. (PMID: 30383829)
EMBO J. 2002 Jun 3;21(11):2757-68. (PMID: 12032088)
EMBO J. 2002 Dec 2;21(23):6571-80. (PMID: 12456663)
Arch Virol. 2019 Mar;164(3):943-946. (PMID: 30663020)
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9436-41. (PMID: 26159422)
Mol Biol Evol. 2010 Feb;27(2):221-4. (PMID: 19854763)
Front Microbiol. 2017 Oct 25;8:2097. (PMID: 29118750)
PLoS Pathog. 2013;9(7):e1003500. (PMID: 23874204)
J Mol Biol. 2018 Jul 20;430(15):2237-2243. (PMID: 29258817)
Nat Protoc. 2015 Jun;10(6):845-58. (PMID: 25950237)
Nat Struct Mol Biol. 2007 May;14(5):449-51. (PMID: 17417654)
J Mol Biol. 2003 Aug 29;331(5):991-1004. (PMID: 12927536)
Front Genet. 2016 Jun 06;7:99. (PMID: 27375676)
Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E162-E171. (PMID: 29279395)
J Virol. 2004 Jul;78(14):7833-8. (PMID: 15220459)
J Virol. 2006 Sep;80(17):8362-70. (PMID: 16912287)
Virology. 2018 Nov;524:160-171. (PMID: 30199753)
Virology. 1986 May;151(1):146-50. (PMID: 2421482)
J Virol. 2016 Jul 11;90(15):6675-6685. (PMID: 27170751)
Cell. 2002 Nov 27;111(5):733-45. (PMID: 12464184)
Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5108-13. (PMID: 16549795)
J Virol. 1982 Feb;41(2):557-65. (PMID: 6281467)
Biochemistry. 2019 Jan 22;58(3):166-170. (PMID: 30406995)
Mol Cell. 2004 Jan 16;13(1):77-89. (PMID: 14731396)
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W604-8. (PMID: 16845081)
J Virol. 2008 Aug;82(16):8071-84. (PMID: 18417574)
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3484-9. (PMID: 19208801)
PLoS Pathog. 2011 May;7(5):e1002059. (PMID: 21637813)
Viruses. 2019 Jan 14;11(1):. (PMID: 30646565)
Nat Rev Microbiol. 2011 Dec 05;10(1):51-65. (PMID: 22138959)
PLoS Pathog. 2011 Oct;7(10):e1002294. (PMID: 22022266)
Nature. 2019 Jan;565(7740):500-504. (PMID: 30626973)
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W337-43. (PMID: 24799431)
Nucleic Acids Res. 2003 Jul 1;31(13):3320-3. (PMID: 12824317)
تواريخ الأحداث: Date Created: 20200415 Latest Revision: 20200928
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7107822
DOI: 10.1093/nargab/lqz022
PMID: 32289120
قاعدة البيانات: MEDLINE
الوصف
تدمد:2631-9268
DOI:10.1093/nargab/lqz022