دورية أكاديمية
Nanonization techniques to overcome poor water-solubility with drugs.
| العنوان: | Nanonization techniques to overcome poor water-solubility with drugs. |
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| المؤلفون: | Da Silva FLO; Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys , Diamantina, Brazil., Marques MBF; Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys , Diamantina, Brazil.; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais , Belo Horizonte, Brazil., Kato KC; Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys , Diamantina, Brazil., Carneiro G; Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys , Diamantina, Brazil. |
| المصدر: | Expert opinion on drug discovery [Expert Opin Drug Discov] 2020 Jul; Vol. 15 (7), pp. 853-864. Date of Electronic Publication: 2020 Apr 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101295755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-045X (Electronic) Linking ISSN: 17460441 NLM ISO Abbreviation: Expert Opin Drug Discov Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Informa Healthcare |
| مواضيع طبية MeSH: | Nanoparticles*, Pharmaceutical Preparations/*administration & dosage, Administration, Oral ; Biological Availability ; Chemistry, Pharmaceutical ; Drug Carriers/chemistry ; Drug Development ; Humans ; Lipids/chemistry ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/classification ; Solubility ; Water/chemistry |
| مستخلص: | Introduction: Most drugs used in therapy have low water-solubility, a factor that could reduce their dissolution rate and oral bioavailability, representing a challenge in pharmaceutical development. Nanonization of drugs is the reduction of particles to nanoscale, increasing the surface area and consequently the saturation solubility and dissolution rate and resulting in higher bioavailability. Areas Covered: This review provides an overview of the consequences of the poor water-solubility and the main strategies applied to increase the solubility of poorly water-soluble drugs. The relationship between the biopharmaceutical classification system and the solubilization process of the drug is also considered. Finally, it includes how drug nanoparticles and nanocarriers, especially lipid-based nanosystems, can overcome these challenges and which of these approaches are already available on the market. Expert Opinion: Due to the growing importance of nanomedicines, especially for applications in poorly water-soluble drugs, it is important to clearly establish the specifications and quality criteria for nanonized drugs to ensure the quality and safety of nanoparticles. |
| فهرسة مساهمة: | Keywords: Bioavailability; biopharmaceutical Classification System; dissolution rate; drug delivery systems; nanoparticles; self-emulsifying formulations; solubility enhancement |
| المشرفين على المادة: | 0 (Drug Carriers) 0 (Lipids) 0 (Pharmaceutical Preparations) 059QF0KO0R (Water) |
| تواريخ الأحداث: | Date Created: 20200416 Date Completed: 20210407 Latest Revision: 20210407 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/17460441.2020.1750591 |
| PMID: | 32290727 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1746-045X |
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| DOI: | 10.1080/17460441.2020.1750591 |