دورية أكاديمية
Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response.
| العنوان: | Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response. |
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| المؤلفون: | Epple S; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk., Thorpe C; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk., Baker YR; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk., El-Sagheer AH; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk and Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt., Brown T; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk. |
| المصدر: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 May 21; Vol. 56 (41), pp. 5496-5499. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Amides/*chemistry , Oligonucleotides, Antisense/*chemistry , Ribonuclease H/*chemistry, HeLa Cells ; Humans |
| مستخلص: | Antisense oligonucleotides are now entering the clinic for hard-to-treat diseases. New chemical modifications are urgently required to enhance their drug-like properties. We combine amide coupling with standard oligonucleotide synthesis to assemble backbone chimera gapmers that trigger an efficient RNase H response while improving serum life time and cellular uptake. |
| معلومات مُعتمدة: | BB/M011224/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council |
| المشرفين على المادة: | 0 (Amides) 0 (Oligonucleotides, Antisense) EC 3.1.26.4 (Ribonuclease H) |
| تواريخ الأحداث: | Date Created: 20200416 Date Completed: 20210105 Latest Revision: 20211129 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1039/d0cc00444h |
| PMID: | 32292963 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1364-548X |
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| DOI: | 10.1039/d0cc00444h |