دورية أكاديمية
أعرض في EDS

Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells.

التفاصيل البيبلوغرافية
العنوان: Transcriptome sequencing analysis of mono‑ADP‑ribosylation in colorectal cancer cells.
المؤلفون: Zhang NN; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China., Lin T; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China., Xiao M; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China., Li QS; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China., Li X; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China., Yang L; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China., Wang CL; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China., Wang YL; Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China.
المصدر: Oncology reports [Oncol Rep] 2020 May; Vol. 43 (5), pp. 1413-1428. Date of Electronic Publication: 2020 Feb 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE
أسماء مطبوعة: Publication: <2003->: Athens : D.A. Spandidos
Original Publication: [Athens, Greece] : National Hellenic Research Foundation, 1994-
مواضيع طبية MeSH: Mutation*, Colorectal Neoplasms/*genetics , Gene Expression Profiling/*methods , Histones/*genetics, ADP-Ribosylation ; Cell Line, Tumor ; Colorectal Neoplasms/metabolism ; Disease Progression ; Epigenesis, Genetic ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Histones/chemistry ; Humans ; Molecular Sequence Annotation ; Protein Interaction Maps
مستخلص: Colorectal cancer (CRC) is a global health concern. The role of epigenetics in tumors has garnered increasing interest. ADP ribosylation is an epigenetic modification that is associated with a variety of biological functions and diseases, and its association with tumor development and progression has been hypothesized. However, due to the limitations of available techniques and methods, ADP ribosylation of specific sites is difficult to determine. In previous studies, it was shown that arginine‑117 of histone 3 (H3R117) in Lovo cells can be modified by mono‑ADP‑ribosylation. This site was mutated and Lovo cells overexpressing this mutant construct were established. In the present study, the expression of differentially expressed genes (DEGs) between untransfected Lovo cells and H3R117A Lovo cells was analyzed. A total of 58,174 DEGs were identified, of which 2,324 were significantly differentially expressed (q‑value <0.05; fold change >2). Functional annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment was used to analyze the functions and possible roles of the DEGs. The DEGs were enriched in pathways associated with metabolic process, catalytic activity, organelle and chromatin structure, and dynamics. Through this comprehensive and systematic analysis, the role of mono‑ADP‑ribosylation in CRC was examined, providing a foundation for future studies.
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فهرسة مساهمة: Keywords: CRC; epigenetic; histone modification; mono ADP ribosylation; transcriptome sequencing; differential gene expression
المشرفين على المادة: 0 (Histones)
تواريخ الأحداث: Date Created: 20200424 Date Completed: 20210205 Latest Revision: 20211026
رمز التحديث: 20240513
مُعرف محوري في PubMed: PMC7107792
DOI: 10.3892/or.2020.7516
PMID: 32323815
قاعدة البيانات: MEDLINE
الوصف
تدمد:1791-2431
DOI:10.3892/or.2020.7516