دورية أكاديمية
أعرض في EDS

Retreatment of chronic hepatitis C patients who failed previous therapy with directly acting antivirals: A multicenter study.

التفاصيل البيبلوغرافية
العنوان: Retreatment of chronic hepatitis C patients who failed previous therapy with directly acting antivirals: A multicenter study.
المؤلفون: El Kassas M; Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt., Alboraie M; Department of Internal Medicine, Al-Azhar University, Cairo, Egypt., El Badry M; Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Aswan University, Aswan, Egypt., Youssef N; Medical Surgical Nursing Department, Faculty of Nursing, Cairo University, Cairo, Egypt; Collage of Nursing, Princess Nourah Bint Abdulrahman University, KSA., Omar H; Endemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Egypt. Electronic address: hebaomar1202@hotmail.com., El Sheemy RY; Tropical Medicine Department, Faculty of Medicine, Minia University, Egypt., Al Balakosy A; Tropical Medicine Department, Ain Shams University, Egypt., Ashraf Ahmed Mohamed O; Internal Medicine Department,Ain Shams University, Egypt., Gamal Naguib Meleak G; Internal Medicine Department,Ain Shams University, Egypt., Dabbous H; Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Egypt., Hassan Ahmed Fouad M; Internal Medicine Department, Gastroenterology and hepatology unit, Ain Shams University, Egypt., Wifi MN; Internal Medicine Department, Hepatogastroenterology Unit, Kasr Al-Ainy School Of Medicine, Cairo University, Cairo, Egypt., Zaky S; Heptogastroenterology and Infectious Diseases Al-Azhar University, Egypt., Tahoon M; Epidemiology and Preventive Medicine, National Liver Institute, Menoufia University, Egypt., El Tahan A; New Cairo Viral Hepatitis Treatment Unit, NCCVH, Egypt., El-Raey F; Hepatogastroenterology and Infectious Diseases Department, Damietta Faculty of Medicine Al-Azhar university, Egypt., Ezzat S; Epidemiology and Preventive Medicine, National Liver Institute, Menoufia University, Egypt., Doss W; Endemic Medicine and Hepatology Department, Faculty of Medicine, Cairo University, Egypt.
المصدر: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2020 Jul; Vol. 96, pp. 367-370. Date of Electronic Publication: 2020 Apr 20.
نوع المنشور: Journal Article; Multicenter Study; Observational Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Hamilton, ON : Elsevier
Original Publication: Hamilton, ON : Decker, c1996-
مواضيع طبية MeSH: Antiviral Agents/*administration & dosage , Hepatitis C, Chronic/*drug therapy, Adult ; Drug Therapy, Combination ; Egypt ; Female ; Hepacivirus/drug effects ; Hepacivirus/physiology ; Hepatitis C, Chronic/virology ; Humans ; Male ; Middle Aged ; Retreatment ; Retrospective Studies ; Sofosbuvir/administration & dosage ; Treatment Outcome
مستخلص: Aim of the Study: The current study aimed to evaluate the efficacy of different DAAs regimens in the treatment of chronic hepatitis C (CHC) Egyptian patients who failed to achieve SVR after their treatment with SOF-based regimens.
Methods: This was a retrospective observational multicenter study that included CHC patients that failed to achieve cure on SOF-based regimens who were re-treated using different DAAs regimen and were allocated according to national guidelines for the treatment of hepatitis C. Primary outcome was to assess the SVR12 rate among prior non-responders after retreatment with a second course of DAAs.
Results: Our study included 172 patients who failed to achieve SVR after treatment with SOF-based treatment regimen [age: 51.2 ± 11.3, 58.7% men]. Included patients were retreated using SOF/DCV/RBV, SOF/ r/PAR /OMB /RBV, SOF/DCV/SIM, SOF/LDV ± RBV or SIM/SOF. SVR12 was successfully attained in 95.35% (164/172) of the included non-responders.
Conclusion: The current multicenter study proved the efficacy of various DAAs regimens issued by the National Committee for Control of Viral Hepatitis for retreatment of relapsed CHC Egyptian patients.
(Copyright © 2020. Published by Elsevier Ltd.)
فهرسة مساهمة: Keywords: HCV; Retreatment; non-responders
المشرفين على المادة: 0 (Antiviral Agents)
WJ6CA3ZU8B (Sofosbuvir)
تواريخ الأحداث: Date Created: 20200424 Date Completed: 20200908 Latest Revision: 20200908
رمز التحديث: 20240628
DOI: 10.1016/j.ijid.2020.04.022
PMID: 32325275
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-3511
DOI:10.1016/j.ijid.2020.04.022